, INSERM U1219, Groupe d'Imagerie Neurofonctionnelle CNRS/CEAU5293

(. B. , ). , U. Bordeaux, (. G. , C. T. et al., Boston University School of Public Health; The National Heart, Lung, and Blood Institute's Framingham Heart Study, and Departments of Epidemiology (B.M.P., W.T.L.), Health Services (B.M.P.)

E. H. , R. S. , J. W. , M. B. , and J. D. , University of Texas Health Science Center at Houston; Institute for Stroke and Dementia Research, Institute for Medical Informatics, Statistics and Documentation (E.H.), and Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging)

M. I. and Y. , Population Health Sciences, Brain Center Rudolf Magnus (M.K.I.), Department of Epidemiology, Julius Center for Health Sciences and Primary Care

P. John,

B. D. and P. F. ,

, Institute of Cardiovascular Science, Faculty of Population Health Sciences (F.W.A.), and Farr Institute of Health Informatics Research and Institute of Health Informatics, Frankston Hospital, Central Clinical School, and School of Clinical Sciences

C. L. , S. Seshadri, ). , S. Antonio, ;. Chauhan et al., from the French National Research Agency (ANR) and from the Fondation Leducq. S.D. is supported by a starting grant from the European Research Council (SEGWAY), a grant from the Joint Programme of Neurodegenerative Disease research (BRIDGET), from the European Union's Horizon 2020 research and innovation programme under grant agreements No 643417 & No 640643, and by the Initiative of Excellence of Bordeaux University, Munich Cluster for Systems Neurology (SyNergy) (M.D.), p.24

. Ag026395, Banner Sun Health Research Institute, P30 AG019610, p.1

R. Ag10483, . Ca129769, and . R01-mh080295, , p.50

R. Ag008702 and . University, AG05128; Emory University, AG025688; Group Health Research Institute, UO1 AG06781, UO1 HG004610; Indiana University, pp.30-10133

. Ag005146, Massachusetts General Hospital, P50 AG005134; Mayo Clinic, P50 AG016574; Mount Sinai School of Medicine, P50 AG005138, P01 AG002219, pp.30-013854

, Oregon Health & Science University, p.30

. Ag008017, P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, pp.1-30146

. Tgen, University of Alabama at Birmingham, P50 AG016582, UL1RR02777; University of Arizona, R01 AG031581, pp.30-010129

P. Ag016575 and . Ag016576, P50 AG005131; University of California, San Francisco, P50 AG023501, P01 AG019724, P50, p.1

. Ag027944,

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