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Focal and diffuse cervical spinal cord damage in patients with early relapsing–remitting MS: A multicentre magnetisation transfer ratio study

Benoît Combès 1, * Anne Kerbrat 1 Jean-Christophe Ferré 1 Virginie Callot 2 Josefina Maranzano 3 Atef Badji 4 Emmanuelle Le Page 5 Pierre Labauge 6 Xavier Ayrignac 6 Clarisse Carra Dallière 6 Nicolas Menjot de Champfleur 7 Jean Pelletier 8 Adil Maarouf 9 Jérôme de Sèze 10 Nicolas Collongues 11 David Brassat 12 Françoise Durand-Dubief 13 Christian Barillot 1 Elise Bannier 1 Gilles Edan 1
* Corresponding author
1 Empenn
INSERM - Institut National de la Santé et de la Recherche Médicale, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
2 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM]
3 Montreal Neurological Institute and Hospital
4 UNF-CRIUGM - Unité de Neuroimagerie Fonctionnelle [Montréal]
5 CHU Pontchaillou [Rennes]
6 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
7 INM - Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs
8 CRMBM - Centre de résonance magnétique biologique et médicale
9 Hôpital Maison Blanche
10 LNV - Laboratoire de Neuroimagerie in Vivo
11 FMTS - Fédération de Médecine Translationnelle de Strasbourg
12 Neurologie vasculaire, pathologie neuro-dégénérative et explorations fonctionnelles du système nerveux [Toulouse]
13 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Background - Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives - The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing-remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. Methods - We included 60 patients with RRMS <12  months and 34 age-matched controls at five centres. Axial T2*w, sagittal T2w, sagittal phase-sensitive inversion recovery (PSIR), 3DT1w, and axial magnetisation transfer (MT) images were acquired from C1 to C7. Lesions were manually labelled and mean MTR values computed both for the whole SC and for normal-appearing SC in different regions of interest. Results - Mean whole SC MTR was significantly lower in patients than controls (33.7 vs 34.9  pu,   =  0.00005), even after excluding lesions (33.9  pu,   =  0.0003). We observed a greater mean reduction in MTR for vertebral levels displaying the highest lesion loads (C2-C4). In the axial plane, we observed a greater mean MTR reduction at the SC periphery and barycentre. Conclusion - Cervical SC tissue damage measured using MTR is not restricted to macroscopic lesions in patients with early RRMS and is not homogeneously distributed.
Keywords : Spinal cord magnetisation transfer imaging quantitative MRI relapsing–remitting multiple sclerosis
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Journal articles
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https://www.hal.inserm.fr/inserm-02457569
Contributor : Gilles Edan <>
Submitted on : Tuesday, January 28, 2020 - 11:08:24 AM
Last modification on : Thursday, February 18, 2021 - 2:02:57 PM

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INSERM | UNIV-TLSE3 | HCL | CRMBM | CREATIS | UNIV-RENNES1 | INRIA | CENTRALESUPELEC | UNIV-ST-ETIENNE | UNIV-LYON1 | INSA-LYON | BS | UNIV-MONTPELLIER | SITE-ALSACE | UNIV-RENNES | UNIV-AMU | INSA-GROUPE | IRISA | CNRS | UDL | UR1-UFR-ISTIC | INSA-RENNES

Citation

Benoît Combès, Anne Kerbrat, Jean-Christophe Ferré, Virginie Callot, Josefina Maranzano, et al.. Focal and diffuse cervical spinal cord damage in patients with early relapsing–remitting MS: A multicentre magnetisation transfer ratio study. Multiple Sclerosis Journal, SAGE Publications, 2019, 25 (8), pp.1113-1123. ⟨10.1177/1352458518781999⟩. ⟨inserm-02457569⟩

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