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Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Amanda Fretts 1 Fumiaki Imamura 2 Matti Marklund Renata Micha 3 Jason Wu Rachel Murphy Kuo-Liong Chien Barbara Mcknight Nathan Tintle Nita Forouhi 4 Waqas Qureshi Jyrki Virtanen Kerry Wong Alexis Wood Maria Lankinen Kalina Rajaobelina 5, 6 Tamara B. Harris 7 Luc Djoussé Bill Harris Nick Wareham 8 Lyn Steffen Markku Laakso 9 Jenna Veenstra Cécilia Samieri 6 Ingeborg Brouwer Chaoyu Ian yu Albert Koulman 10 Brian Steffen Catherine Helmer 11, 6 Nona Sotoodehnia David Siscovick Vilmundur Gudnason 12 Lynne Wagenknecht Sari Voutilainen 13 Michael Tsai 14 Matti Uusitupa 15 Anya Kalsbeek Claudine Berr 16 Dariush Mozaffarian 3 Rozenn Lemaitre 
Abstract : BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
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Submitted on : Tuesday, January 28, 2020 - 10:54:36 AM
Last modification on : Monday, June 27, 2022 - 12:00:22 PM

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Amanda Fretts, Fumiaki Imamura, Matti Marklund, Renata Micha, Jason Wu, et al.. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. The American Journal of Clinical Nutrition, Oxford University Press, 2019, 109 (4), pp.1216-1223. ⟨10.1093/ajcn/nqz005⟩. ⟨inserm-02457545⟩

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