H. Karasuyama, K. Miyake, S. Yoshikawa, and Y. Yamanishi, Multifaceted roles of basophils in health and disease, J. Allergy Clin. Immunol, vol.142, pp.370-380, 2018.

D. Voehringer, Protective and pathological roles of mast cells and basophils, Nat. Rev. Immunol, vol.13, pp.362-375, 2013.

M. Sharma and J. Bayry, Autoimmunity: Basophils in autoimmune and inflammatory diseases, Nat. Rev. Rheumatol, vol.11, pp.129-131, 2015.

J. T. Schroeder, Basophils: Emerging roles in the pathogenesis of allergic disease, Immunol. Rev, vol.242, pp.144-160, 2011.

S. V. Kaveri, L. Mouthon, and J. Bayry, Basophils and nephritis in lupus, N. Engl. J. Med, vol.363, pp.1080-1082, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-02455576

N. Charles, D. Hardwick, E. Daugas, G. G. Illei, and J. Rivera, Basophils and the T helper 2 environment can promote the development of lupus nephritis, Nat. Med, vol.16, pp.701-707, 2010.

, Int. J. Mol. Sci, vol.2020, p.510

C. Pellefigues, B. Dema, Y. Lamri, F. Saidoune, N. Chavarot et al., Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs, Nat. Commun, vol.9, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02445648

S. Balam, G. Schiechl-brachner, S. Buchtler, D. Halbritter, K. Schmidbauer et al., IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils, J. Immunol, vol.202, pp.3514-3523, 2019.

B. J. Sutton, A. M. Davies, H. J. Bax, and S. N. Karagiannis, IgE Antibodies: From Structure to Function and Clinical Translation, Antibodies, vol.8, 2019.

J. Henault, J. M. Riggs, J. L. Karnell, V. M. Liarski, J. Li et al., Self-reactive IgE exacerbates interferon responses associated with autoimmunity, Nat. Immunol, vol.17, pp.196-203, 2016.

J. Bayry, Lupus pathogenesis: Role of IgE autoantibodies, Cell Res, vol.26, pp.271-272, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02455478

P. Gasser and A. Eggel, Targeting IgE in allergic disease, Curr. Opin. Immunol, vol.54, pp.86-92, 2018.

C. Ritter, M. Battig, R. Kraemer, and B. M. Stadler, IgE hidden in immune complexes with anti-IgE autoantibodies in children with asthma, J. Allergy Clin. Immunol, vol.88, pp.793-801, 1991.

Y. C. Chan, F. Ramadani, A. F. Santos, P. Pillai, L. Ohm-laursen et al., Auto-anti-IgE": Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation, J. Allergy Clin. Immunol, vol.134, pp.1394-1401, 2014.

D. Macglashan, Autoantibodies to IgE and Fc?RI and the natural variability of spleen tyrosine kinase expression in basophils, J. Allergy Clin. Immunol, vol.143, pp.1100-1107, 2019.

E. Fiebiger, D. Maurer, H. Holub, B. Reininger, G. Hartmann et al., Serum IgG autoantibodies directed against the alpha chain of Fc?RI: A selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?, J. Clin. Investig, vol.96, pp.2606-2612, 1995.

M. P. Horn, J. M. Pachlopnik, M. Vogel, M. Dahinden, F. Wurm et al., Conditional autoimmunity mediated by human natural anti-Fc?RIalpha autoantibodies?, FASEB J, vol.15, pp.2268-2274, 2001.

C. Galeotti, E. Stephen-victor, A. Karnam, M. Das, L. Gilardin et al., Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE, J. Allergy Clin. Immunol, vol.144, pp.524-535, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02284256

C. Galeotti, A. Karnam, J. D. Dimitrov, A. Chevailler, S. V. Kaveri et al., Anti-IgE IgG autoantibodies isolated from therapeutic normal IgG intravenous immunoglobulin induce basophil activation, Cell. Mol. Immunol, 2020.
URL : https://hal.archives-ouvertes.fr/inserm-02455411

C. Galeotti, S. V. Kaveri, and J. Bayry, IVIG-mediated effector functions in autoimmune and inflammatory diseases, Int. Immunol, vol.29, pp.491-498, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01723553

F. Shakib and A. Powell-richards, Elucidation of the epitope locations of human autoanti-IgE: Recognition of two epitopes located within the C epsilon 2 and the C epsilon 4 domains, Int. Arch. Allergy Appl. Immunol, vol.95, pp.102-108, 1991.

F. J. Malveaux, M. C. Conroy, N. F. Adkinson, . Jr, and L. M. Lichtenstein, IgE receptors on human basophils. Relationship to serum IgE concentration, J. Clin. Investig, vol.62, pp.176-181, 1978.

J. J. Pruzansky, L. C. Grammer, R. Patterson, and M. Roberts, Dissociation of IgE from receptors on human basophils. I. Enhanced passive sensitization for histamine release, J. Immunol, vol.131, pp.1949-1953, 1983.

R. Alam, P. A. Forsythe, J. A. Rankin, M. C. Boyars, M. A. Lett-brown et al., Sensitivity of basophils to histamine releasing factor(s) of various origin: Dependency on allergic phenotype of the donor and surface-bound IgE, J. Allergy Clin. Immunol, vol.86, pp.73-81, 1990.

M. Hide, D. M. Francis, C. E. Grattan, J. Hakimi, J. P. Kochan et al., Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria, N. Engl. J. Med, vol.328, pp.1599-1604, 1993.

M. Hide, T. Tanaka, Y. Yamamura, O. Koro, and S. Yamamoto, IgE-mediated hypersensitivity against human sweat antigen in patients with atopic dermatitis, Acta Derm. Venereol, vol.82, pp.335-340, 2002.

A. M. Greer, N. Wu, A. L. Putnam, P. G. Woodruff, P. Wolters et al., Serum IgE clearance is facilitated by human FcepsilonRI internalization, J. Clin. Investig, vol.124, pp.1187-1198, 2014.

, Int. J. Mol. Sci, vol.2020, p.510

Y. Yanase, Y. Matsuo, T. Kawaguchi, K. Ishii, A. Tanaka et al., Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens, Int. J. Mol. Sci, vol.20, p.45, 2019.

D. W. Macglashan and . Jr, Releasability of human basophils: Cellular sensitivity and maximal histamine release are independent variables, J. Allergy Clin. Immunol, vol.91, pp.605-615, 1993.

L. A. Youssef, M. Schuyler, B. S. Wilson, and J. M. Oliver, Roles for the high affinity IgE receptor, Fc?RI, of human basophils in the pathogenesis and therapy of allergic asthma: Disease promotion, protection or both?, Open Allergy J, vol.3, pp.91-101, 2010.

D. Voehringer, Basophil modulation by cytokine instruction, Eur. J. Immunol, vol.42, pp.2544-2550, 2012.

T. Shen, S. Kim, J. S. Do, L. Wang, C. Lantz et al., T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival, Int. Immunol, vol.20, pp.1201-1209, 2008.

B. M. Sullivan, H. E. Liang, J. K. Bando, D. Wu, L. E. Cheng et al., Genetic analysis of basophil function in vivo, Nat. Immunol, vol.12, pp.527-535, 2011.

M. Sharma, M. Das, E. Stephen-victor, C. Galeotti, A. Karnam et al., Regulatory T cells induce activation rather than suppression of human basophils, Sci. Immunol, vol.3, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01817714

J. M. Leyva-castillo, P. Hener, P. Michea, H. Karasuyama, S. Chan et al., Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade, Nat. Commun, 2013.

T. Kawakami and S. J. Galli, Regulation of mast-cell and basophil function and survival by IgE, Nat. Rev. Immunol, vol.2, pp.773-786, 2002.

X. Zheng, A. Karsan, V. Duronio, F. Chu, D. C. Walker et al., Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: Requirement of NF-?B-dependent and -independent pathways, Immunology, vol.107, pp.306-315, 2002.

C. Yoshimura, M. Yamaguchi, M. Iikura, S. Izumi, K. Kudo et al., Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3, J. Allergy Clin. Immunol, vol.109, pp.817-823, 2002.

A. C. Redrup, B. P. Howard, D. W. Macglashan, . Jr, A. Kagey-sobotka et al., Differential regulation of IL-4 and IL-13 secretion by human basophils: Their relationship to histamine release in mixed leukocyte cultures, J. Immunol, vol.160, pp.1957-1964, 1998.

S. A. Didichenko, N. Spiegl, T. Brunner, and C. Dahinden, IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils, Blood, vol.112, pp.3949-3958, 2008.

E. Stephen-victor, M. Das, M. Sharma, C. Galeotti, H. Fohrer-ting et al., Demystification of enigma on antigen-presenting cell features of human basophils: Data from secondary lymphoid organs, vol.102, p.233, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01471780

N. Salabert-le-guen, C. Hemont, A. Delbove, C. Poli, C. Braudeau et al., Thymic stromal lymphopoietin does not activate human basophils, J. Allergy Clin. Immunol, vol.141, pp.1476-1479, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01885566

B. M. Salter, J. P. Oliveria, G. Nusca, S. G. Smith, R. M. Watson et al., Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent, J. Allergy Clin. Immunol, vol.136, pp.1636-1644, 2015.

I. Iwamoto, Y. Nawata, T. Koike, M. Tanaka, H. Tomioka et al., Relationship between anti-IgE autoantibody and severity of bronchial asthma, Int. Arch. Allergy Appl. Immunol, vol.90, pp.414-416, 1989.

W. Czech, B. M. Stadler, E. Schopf, and A. Kapp, IgE autoantibodies in atopic dermatitis-Occurrence of different antibodies against the CH3 and the CH4 epitopes of IgE, Allergy, vol.50, pp.243-248, 1995.

Y. Nawata, T. Koike, T. Yanagisawa, I. Iwamoto, T. Itaya et al., Anti-IgE autoantibody in patients with bronchial asthma, Clin. Exp. Immunol, vol.58, pp.348-356, 1984.

S. Izaki, S. Toyoshima, T. Endo, K. Kanegae, S. Nunomura et al., Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce Fc?RI crosslinking, as compared to anti-Fc?RI? AAbs, Allergol. Int, vol.68, pp.342-351, 2019.

F. Shakib and S. J. Smith, In vitro basophil histamine-releasing activity of circulating IgG1 and IgG4 autoanti-IgE antibodies from asthma patients and the demonstration that anti-IgE modulates allergen-induced basophil activation, Clin. Exp. Allergy, vol.24, pp.270-275, 1994.

B. L. Gruber, L. D. Kaufman, M. J. Marchese, W. Roth, and A. P. Kaplan, Anti-IgE autoantibodies in systemic lupus erythematosus. Prevalence and biologic activity, Arthritis Rheum, vol.31, pp.1000-1006, 1988.

J. A. Swainson, P. B. Wilson, P. Dore, and R. S. Pumphrey, Evidence for circulating complexes containing IgE in patients with atopic dermatitis, Int. Arch. Allergy Appl. Immunol, vol.76, pp.237-242, 1985.

E. Passante and N. Frankish, The RBL-2H3 cell line: Its provenance and suitability as a model for the mast cell, Inflamm. Res, vol.58, pp.737-745, 2009.

T. Blom, R. Huang, M. Aveskogh, K. Nilsson, and L. Hellman, Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte, Eur. J. Immunol, vol.22, pp.2025-2032, 1992.

C. G. Magnusson, J. Haard, P. Matsson, T. Karlsson, K. Nilsson et al., Demonstration of specific high-affinity Fc epsilon-receptors on the human basophil-like leukemia cell line KU812 by flow cytometry, Allergy, vol.50, pp.72-77, 1995.

T. Ishizaka and K. Ishizaka, Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH, J. Immunol, vol.112, pp.1078-1084, 1974.

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