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Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator

Alice Huertas 1, 2, 3, 4 Ly Tu 1, 2, 3 Marc Humbert 1, 2, 3, 4 Christophe Guignabert 1, 2, 3
1 Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
2 UP11 UFR Médecine - Université Paris-Sud 11 - Faculté de médecine
3 Université Paris-Saclay
4 Service de pneumologie [CHU Bicêtre]
Abstract : This review seeks to provide an update of preclinical findings and available clinical data on the chronic persistent inflammation and its direct role on the pulmonary arterial hypertension (PAH) progression. We reviewed the different mechanisms by which the inflammatory and immune pathways contribute to the structural and functional changes occurring in the three vascular compartments: the tunica intima, tunica media, and tunica adventitia. We also discussed how these inflammatory mediator changes may serve as a biomarker of the PAH progression and summarize unanswered questions and opportunities for future studies in this area.
Keywords : smooth muscle cells adventitial fibroblasts endothelial cells innate and adaptive immunity pulmonary vascular remodeling Pulmonary hypertension
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Journal articles
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https://www.hal.inserm.fr/inserm-02454983
Contributor : Christophe Guignabert <>
Submitted on : Saturday, January 25, 2020 - 8:51:45 AM
Last modification on : Thursday, June 25, 2020 - 1:54:02 PM

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Alice Huertas, Ly Tu, Marc Humbert, Christophe Guignabert. Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator. Cardiovascular Research, Oxford University Press (OUP), 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩. ⟨inserm-02454983⟩

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