Skip to Main content Skip to Navigation
Journal articles

Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator

Alice Huertas 1, 2, 3, 4 Ly Tu 1, 2, 3 Marc Humbert 1, 2, 3, 4 Christophe Guignabert 1, 2, 3
1 Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique
2 UP11 UFR Médecine - Université Paris-Sud 11 - Faculté de médecine
3 Université Paris-Saclay
4 Service de pneumologie [CHU Bicêtre]
Abstract : This review seeks to provide an update of preclinical findings and available clinical data on the chronic persistent inflammation and its direct role on the pulmonary arterial hypertension (PAH) progression. We reviewed the different mechanisms by which the inflammatory and immune pathways contribute to the structural and functional changes occurring in the three vascular compartments: the tunica intima, tunica media, and tunica adventitia. We also discussed how these inflammatory mediator changes may serve as a biomarker of the PAH progression and summarize unanswered questions and opportunities for future studies in this area.
Keywords : smooth muscle cells adventitial fibroblasts endothelial cells innate and adaptive immunity pulmonary vascular remodeling Pulmonary hypertension
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-02454983
Contributor : Christophe Guignabert <>
Submitted on : Saturday, January 25, 2020 - 8:51:45 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:52 AM

Links full text

openaccess

Identifiers

Collections

Citation

Alice Huertas, Ly Tu, Marc Humbert, Christophe Guignabert. Chronic Inflammation Within the Vascular Wall in Pulmonary Arterial Hypertension: More than a Spectator. Cardiovascular Research, Oxford University Press (OUP), 2019, pp.cvz308. ⟨10.1093/cvr/cvz308⟩. ⟨inserm-02454983⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

69