Skip to Main content Skip to Navigation
Journal articles

Stratégies génétiques, immunologiques et pharmacologiques au service d'une nouvelle génération de virus anticancéreux

Abstract : Since over a century, medical literature has reported cases of viral infections leading to tumour regression. This phenomenon, now understood, can be exploited for cancer therapy. It involves viruses defined as "oncolytic". These viruses, either wild-type or genetically engineered, replicate preferentially in malignant cells. They induce tumour regression through various mechanisms including direct cell lysis and stimulation of an anti-tumour immune response. Several oncolytic viruses have reached late-stage clinical investigation and could be approved soon for treating certain neoplasms. While already promising, there is still room for improvement and various genetic, immunological, and pharmacological strategies are currently under development to increase their therapeutic efficacy.
Complete list of metadatas

Cited literature [43 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02454927
Contributor : Jonathan Pol <>
Submitted on : Friday, January 24, 2020 - 9:11:17 PM
Last modification on : Wednesday, October 14, 2020 - 3:58:51 AM
Long-term archiving on: : Saturday, April 25, 2020 - 5:00:48 PM

File

2013-02 - MS - Pol J, Le Boeuf...
Files produced by the author(s)

Identifiers

Citation

Jonathan Pol, Fabrice Le Boeuf, Jean-Simon Diallo. Stratégies génétiques, immunologiques et pharmacologiques au service d'une nouvelle génération de virus anticancéreux. médecine/sciences, EDP Sciences, 2013, ⟨10.1051/medsci/2013292014⟩. ⟨inserm-02454927⟩

Share

Metrics

Record views

258

Files downloads

662