New treatments for renal cell carcinoma: targeted therapies, J Natl Compr Canc Netw, vol.7, issue.6, pp.645-656, 2009. ,
The TOR pathway: a target for cancer therapy, Nat Rev Cancer, vol.4, issue.5, pp.335-348, 2004. ,
Superoxide anions regulate TORC1 and its ability to bind Fpr1:rapamycin complex, Proc Natl Acad Sci, vol.105, issue.39, pp.15166-15171, 2008. ,
A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide, J Biol Chem, vol.273, issue.34, pp.21489-21496, 1998. ,
Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae, Mol Gen Genet, vol.262, issue.6, pp.1081-1092, 2000. ,
PTPA regulating PP2A as a dual specificity phosphatase, Methods Mol Biol, vol.93, pp.103-115, 1998. ,
Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A, J Biol Chem, vol.269, issue.22, pp.15668-15675, 1994. ,
The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA, Curr Genet, vol.46, issue.2, pp.72-81, 2004. ,
The phosphotyrosyl phosphatase activator, Ncs1p (Rrd1p), functions with Cla4p to regulate the G(2)/M transition in Saccharomyces cerevisiae, Mol Cell Biol, vol.21, issue.2, pp.488-500, 2001. ,
Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2, Biochem J, vol.386, pp.93-102, 2005. ,
Rapamycinmodulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins, Proc Natl Acad Sci, vol.96, issue.26, pp.14866-14870, 1999. ,
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast, Science, vol.253, issue.5022, pp.905-909, 1991. ,
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae, Microbiol Mol Biol Rev, vol.66, issue.4, pp.579-591, 2002. ,
Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast, Mol Cell Biol, vol.24, issue.1, pp.338-351, 2004. ,
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors, Nature, vol.402, issue.6762, pp.689-692, 1999. ,
The TOR kinases link nutrient sensing to cell growth, J Biol Chem, vol.276, issue.13, pp.9583-9586, 2001. ,
Regulation of ribosome biogenesis by the rapamycinsensitive TOR-signaling pathway in Saccharomyces cerevisiae, Mol Biol Cell, vol.10, issue.4, pp.987-1000, 1999. ,
The Saccharomyces cerevisiae phosphatase activator RRD1 is required to, Jouvet et al. BMC Molecular Biology, vol.11, 2010. ,
, modulate gene expression in response to rapamycin exposure, Genetics, vol.172, issue.2, pp.1369-1372, 2006.
Van Hoof C: The Protein Phosphatase 2A Phosphatase Activator Is a Novel Peptidyl-Prolyl cis/ trans-Isomerase, J Biol Chem, vol.281, issue.10, pp.6349-6357, 2006. ,
Protein folding. Prolyl isomerases join the fold, Curr Biol, vol.5, issue.9, pp.993-994, 1995. ,
Conformational specificity of chymotrypsin toward proline-containing substrates, Biochim Biophys Acta, vol.791, issue.1, pp.87-97, 1984. ,
Genetic interactions with C-terminal domain (CTD) kinases and the CTD of RNA Pol II suggest a role for ESS1 in transcription initiation and elongation in Saccharomyces cerevisiae, Genetics, vol.167, issue.1, pp.93-105, 2004. ,
Pin1 modulates RNA polymerase II activity during the transcription cycle, Genes Dev, vol.21, issue.22, pp.2950-2962, 2007. ,
The Ess1 prolyl isomerase is required for transcription termination of small noncoding RNAs via the Nrd1 pathway, Mol Cell, vol.36, issue.2, pp.255-266, 2009. ,
Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p, Mol Biol Cell, vol.15, issue.5, pp.2049-2060, 2004. ,
DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats, Genes Dev, vol.6, issue.3, pp.426-438, 1992. ,
Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels, Biochem Cell Biol, vol.80, issue.6, pp.789-796, 2002. ,
A Genome-Wide Screen in Saccharomyces cerevisiae Reveals Altered Transport As a Mechanism of Resistance to the Anticancer Drug Bleomycin, Cancer Res, vol.64, issue.3, pp.1102-1109, 2004. ,
Purification of elongating RNA polymerase II and other factors from yeast chromatin, Methods Enzymol, vol.371, pp.491-498, 2003. ,
Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability, Mol Cell Biol, vol.21, issue.5, pp.1647-1655, 2001. ,
, Circular Dichroism and the Conformational Analysis of Biomolecules, 1996.
, Transcriptional regulatory networks in Saccharomyces cerevisiae, vol.298, pp.799-804, 2002.
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine, Proc Natl Acad Sci, vol.99, issue.10, pp.6784-6789, 2002. ,
Radding CM: Human and yeast Rad52 proteins promote DNA strand exchange, Proc Natl Acad Sci, vol.101, issue.26, pp.9568-9572, 2004. ,
Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation, Mol Cell Biol, vol.11, issue.9, pp.4537-4544, 1991. ,
Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation, J Biol Chem, vol.274, issue.44, pp.31583-31587, 1999. ,
Conformation of the RNA polymerase II C-terminal domain: circular dichroism of long and short fragments, J Mol Biol, vol.297, issue.1, pp.119-133, 2000. ,
BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels, Mol Cell Biol, vol.24, issue.16, pp.6947-6956, 2004. ,
Detecting phosphorylation-dependent interactions with the C-terminal domain of RNA polymerase II subunit Rpb1p using a yeast two-hybrid assay, RNA Biol, vol.5, issue.1, pp.1-4, 2008. ,
Key features of the interaction between Pcf11 CID and RNA polymerase II CTD, Nat Struct Mol Biol, vol.12, issue.2, pp.144-151, 2005. ,
Proline isomerization of histone H3 regulates lysine methylation and gene expression, Cell, vol.126, issue.5, pp.905-916, 2006. ,
Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide, Cancer Res, vol.53, issue.14, pp.3250-3252, 1993. ,
Regulon-specific control of transcription elongation across the yeast genome, PLoS Genet, vol.5, issue.8, p.1000614, 2009. ,
Pin1 modulates the structure and function of human RNA polymerase II, Genes Dev, vol.17, issue.22, pp.2765-2776, 2003. ,
Nuclear speckles: a model for nuclear organelles, Nat Rev Mol Cell Biol, vol.4, issue.8, pp.605-612, 2003. ,
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation, Cell, vol.113, issue.4, pp.429-432, 2003. ,
Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1, Genes Dev, vol.17, issue.8, pp.1030-1042, 2003. ,
, Nat Struct Biol, vol.10, issue.9, pp.679-680, 2003.
Molecular determinants of a native-state prolyl isomerization, J Mol Biol, vol.387, issue.4, pp.1017-1031, 2009. ,
Prolyl cis-trans isomerization as a molecular timer, Nat Chem Biol, vol.3, issue.10, pp.619-629, 2007. ,
Vanishingly low levels of Ess1 prolylisomerase activity are sufficient for growth in Saccharomyces cerevisiae, J Biol Chem, vol.280, issue.16, pp.15510-15517, 2005. ,
Genomic expression programs in the response of yeast cells to environmental changes, Mol Biol Cell, vol.11, issue.12, pp.4241-4257, 2000. ,
Rrd1 isomerizes RNA polymerase II in response to rapamycin, BMC Molecular Biology, vol.11, p.92, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-02454582