Skip to Main content Skip to Navigation

RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation

Abstract : In Saccharomyces cerevisiae, the immunosuppressor rapamycin engenders the degradation of excessive RNA polymerase II leading to growth arrest but the regulation of this process is not known yet. Here, we show that this mechanism is dependent on the peptidyl prolyl cis/trans isomerase Rrd1. Strikingly this degradation is independent of RNA polymerase II polyubiquitylation and does not require the elongation factor Elc1. Our data reveal that there are at least two alternative pathways to degrade RNA polymerase II that depend on different type of stresses.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-02454571
Contributor : Ana Paula Dutra Azevedo <>
Submitted on : Friday, January 24, 2020 - 4:08:08 PM
Last modification on : Saturday, January 25, 2020 - 1:25:57 AM

Identifiers

Collections

Citation

Nathalie Jouvet, Jérémie Poschmann, Julie Douville, Rim Marrakchi, Dindial Ramotar. RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation. Biochemical and Biophysical Research Communications, Elsevier, 2011, 413 (2), pp.248-253. ⟨10.1016/j.bbrc.2011.08.079⟩. ⟨inserm-02454571⟩

Share

Metrics

Record views

19