 |
Journal articles
RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation
Abstract : In Saccharomyces cerevisiae, the immunosuppressor rapamycin engenders the degradation of excessive RNA polymerase II leading to growth arrest but the regulation of this process is not known yet. Here, we show that this mechanism is dependent on the peptidyl prolyl cis/trans isomerase Rrd1. Strikingly this degradation is independent of RNA polymerase II polyubiquitylation and does not require the elongation factor Elc1. Our data reveal that there are at least two alternative pathways to degrade RNA polymerase II that depend on different type of stresses.
https://www.hal.inserm.fr/inserm-02454571
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Friday, January 24, 2020 - 4:08:08 PM
Last modification on : Thursday, January 20, 2022 - 12:56:02 PM
Contributor : Sylvie Le Bihan Connect in order to contact the contributor
Submitted on : Friday, January 24, 2020 - 4:08:08 PM
Last modification on : Thursday, January 20, 2022 - 12:56:02 PM