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Transplantation rénale et sujet âgé : mise au point

Abstract : Due to the increase in life expectancy and the ageing of end-stage renal disease patients, the number of patients older than 65 years receiving a kidney transplant has been continuously growing over the last fifteen years. The benefits of renal transplantation compared to dialysis in terms of survival and quality of life have been shown in selected recipients over 65, or 70 years. However, the age remains the main limiting factor for the access to the waiting list, and the reluctance of the clinicians can be explained by the multiple comorbidities of these candidates, their limited life expectancy or the shortage of grafts. The challenge is to select the candidates who can benefit from renal transplantation, thanks to rigorous cardiovascular and neoplastic evaluation before enrolment and by taking into account the specific characteristics of elderly patients. The living donor appears to be the ideal option for elderly recipients, the alternative being the extended criteria donor, allowing waiting times to be limited. The choice of immunosuppressive therapy is also crucial in these patients at high risk of infectious and cardiovascular complications in whom the occurrence of acute rejection can have severe consequences. There are currently no specific recommendations for immunosuppression in elderly recipients, and we would need large-scale randomized studies to improve the prognosis of renal transplantation in this population.
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Submitted on : Friday, January 24, 2020 - 11:04:58 AM
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Mathilde Lemoine, Dominique Guerrot, Dominique Bertrand. Transplantation rénale et sujet âgé : mise au point. Néphrologie & Thérapeutique, Elsevier Masson, 2018, 14 (2), pp.71-80. ⟨10.1016/j.nephro.2017.06.003⟩. ⟨inserm-02454036⟩



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