N. Mr, G. , N. Mp, . Sbm, J. Pmmcg et al.,

R. H. Adams and K. Alitalo, Molecular regulation of angiogenesis and lymphangiogenesis, Nat Rev Mol Cell Biol, vol.8, pp.464-478, 2007.

C. J. Avraamides, B. Garmy-susini, and J. A. Varner, Integrins in angiogenesis and lymphangiogenesis, Nat Rev Cancer, vol.8, pp.604-617, 2008.

J. P. Baren, G. D. Stewart, A. Stokes, K. Gray, C. J. Pennington et al., ) mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma, Br J Cancer, vol.107, pp.143-149, 2012.

J. W. Bartsch, D. Wildeboer, G. Koller, S. Naus, A. Rittger et al., Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection, J Neurosci, vol.30, pp.12210-12218, 2010.

G. Bergers and L. E. Benjamin, Tumorigenesis and the angiogenic switch, Nat Rev Cancer, vol.3, pp.401-410, 2003.

F. Bertucci, P. Finetti, and D. Birnbaum, Basal breast cancer: a complex and deadly molecular subtype, Curr Mol Med, vol.12, pp.96-110, 2012.

P. Boyle, Triple-negative breast cancer: epidemiological considerations and recommendations, Ann Oncol, vol.23, pp.7-12, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01262979

L. C. Bridges and R. D. Bowditch, ADAM-Integrin Interactions: potential integrin regulated ectodomain shedding activity, Curr Pharm Des, vol.11, pp.837-847, 2005.

M. Cristofanilli, G. T. Budd, M. J. Ellis, A. Stopeck, J. Matera et al., Circulating tumor cells, disease progression, and survival in metastatic breast cancer, N Engl J Med, vol.351, pp.781-791, 2004.

J. S. Desgrosellier and D. A. Cheresh, Integrins in cancer: biological implications and therapeutic opportunities, Nat Rev Cancer, vol.10, pp.9-22, 2010.

M. J. Duffy, E. Mckiernan, N. O'donovan, and P. M. Mcgowan, Role of ADAMs in cancer formation and progression, Clin Cancer Res, vol.15, pp.1140-1144, 2009.

M. J. Duffy, M. Mullooly, N. O'donovan, S. Sukor, J. Crown et al., The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?, Clin Proteomics, vol.8, p.9, 2011.

J. Eyles, A. L. Puaux, X. Wang, B. Toh, C. Prakash et al., Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma, J Clin Invest, vol.120, pp.2030-2039, 2010.

C. Greiner, M. Hunter, F. Rius, P. Huang, and I. Georgakoudi, Confocal backscattering-based detection of leukemic cells in flowing blood samples, Cytometry A, vol.79, pp.874-883, 2011.

A. L. Harris, Hypoxia-a key regulatory factor in tumour growth, Nat Rev Cancer, vol.2, pp.38-47, 2002.

L. J. Hawinkels, K. Zuidwijk, H. W. Verspaget, E. S. De-jonge-muller, W. Van-duijn et al., VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis, Eur J Cancer, vol.44, pp.1904-1913, 2008.

D. Hwu, S. Boutrus, C. Greiner, T. Dimeo, C. Kuperwasser et al., Assessment of the role of circulating breast cancer cells in tumor formation and metastatic potential using in vivo flow cytometry, J Biomed Opt, vol.16, p.40501, 2011.

K. Kelly, G. Hutchinson, D. Nebenius-oosthuizen, A. J. Smith, J. W. Bartsch et al., , 2005.

, Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice, Dev Dyn, vol.232, pp.221-231

G. Koller, U. Schlomann, P. Golfi, T. Ferdous, S. Naus et al., , p.8, 2009.

, MS2/CD156, an emerging drug target in the treatment of inflammatory and invasive pathologies, vol.15, pp.2272-2281

S. Lee, S. M. Jilani, G. V. Nikolova, D. Carpizo, and M. L. Iruela-arispe, Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors, J Cell Biol, vol.169, pp.681-691, 2005.

S. B. Lee, A. Schramme, K. Doberstein, R. Dummer, A. -. Bakky et al., ADAM10 is upregulated in melanoma metastasis compared with primary melanoma, J Invest Dermatol, vol.130, pp.763-773, 2010.

B. K. Linderholm, H. Hellborg, U. Johansson, G. Elmberger, L. Skoog et al., Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer, Ann Oncol, vol.20, pp.1639-1646, 2009.

M. Lohela, M. Bry, T. Tammela, and K. Alitalo, VEGFs and receptors involved in angiogenesis versus lymphangiogenesis, Curr Opin Cell Biol, vol.21, pp.154-165, 2009.

A. J. Majmundar, W. J. Wong, and M. C. Simon, Hypoxia-inducible factors and the response to hypoxic stress, Mol Cell, vol.40, pp.294-309, 2010.

T. Maretzky, A. Evers, W. Zhou, S. L. Swendeman, P. M. Wong et al., Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17, Nat Commun, vol.2, p.229, 2011.

C. T. Mierke, Role of the endothelium during tumor cell metastasis: is the endothelium a barrier or a promoter for cell invasion and metastasis?, J Biophys, p.183516, 2008.

A. J. Minn, G. P. Gupta, P. M. Siegel, P. D. Bos, W. Shu et al., Genes that mediate breast cancer metastasis to lung, Nature, vol.436, pp.518-524, 2005.

R. A. Mohammed, A. Green, S. El-shikh, E. C. Paish, I. O. Ellis et al., Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio-and lymphangiogenesis, Br J Cancer, vol.96, pp.1092-1100, 2007.

G. N. Naumov, L. A. Akslen, and J. Folkman, Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch, Cell Cycle, vol.5, pp.1779-1787, 2006.

A. Pierce, R. Saldova, A. Hamid, U. M. Abrahams, J. L. Mcdermott et al., Levels of specific glycans significantly distinguish lymph node-positive from lymph node-negative breast cancer patients, Glycobiology, vol.20, pp.1283-1288, 2010.

E. A. Price, D. R. Coombe, and J. C. Murray, beta-1 Integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro, Br J Cancer, vol.74, pp.1762-1766, 1996.

H. Rao, G. Lu, H. Kajiya, V. Garcia-palacios, N. Kurihara et al., Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function, J Bone Miner Res, vol.21, pp.1657-1665, 2006.

J. Richens, L. Fairclough, A. M. Ghaemmaghami, J. Mahdavi, F. Shakib et al., The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets, Immunobiology, vol.212, pp.29-38, 2007.

M. Romagnoli, K. Belguise, Z. Yu, X. Wang, E. Landesman-bollag et al., , 2012.

, Epithelial-to-mesenchymal transition induced by TGF-beta1 is mediated by Blimp-1-dependent repression of BMP-5, Cancer Res, vol.72, pp.6268-6278

R. Roy, S. Rodig, D. Bielenberg, D. Zurakowski, and M. A. Moses, ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis, J Biol Chem, vol.286, pp.20758-20768, 2011.

R. Roy, D. Zurakowski, S. Pories, M. L. Moss, and M. A. Moses, Potential of fluorescent metalloproteinase substrates for cancer detection, Clin Biochem, vol.44, pp.1434-1439, 2011.

U. Schlomann, D. Wildeboer, A. Webster, O. Antropova, D. Zeuschner et al., The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion, J Biol Chem, vol.277, pp.48210-48219, 2002.

J. Scott, P. Kuhn, and A. R. Anderson, Unifying metastasis-integrating intravasation, circulation and end-organ colonization, Nat Rev Cancer, vol.12, pp.445-446, 2012.

V. Sriraman, U. Eichenlaub-ritter, J. W. Bartsch, A. Rittger, S. M. Mulders et al., Regulated expression of ADAM8 (a disintegrin and metalloprotease domain 8) in the mouse ovary: evidence for a regulatory role of luteinizing hormone, progesterone receptor, and epidermal growth factor-like growth factors, Biol Reprod, vol.78, pp.1038-1048, 2008.

P. S. Steeg, Tumor metastasis: mechanistic insights and clinical challenges, Nat Med, vol.12, pp.895-904, 2006.

B. Toh, V. Chew, X. Dai, K. Khoo, M. Tham et al., Immune predictors of cancer progression, Immunol Res, vol.53, pp.229-234, 2012.

N. Valkovskaya, H. Kayed, K. Felix, D. Hartmann, N. A. Giese et al., ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer, J Cell Mol Med, vol.11, pp.1162-1174, 2007.

M. J. Van-de-vijver, Y. D. He, L. J. Van't-veer, H. Dai, A. A. Hart et al., A gene-expression signature as a predictor of survival in breast cancer, N Engl J Med, vol.347, pp.1999-2009, 2002.

X. Wang, K. Belguise, N. Kersual, K. H. Kirsch, N. D. Mineva et al., Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2, Nat Cell Biol, vol.9, pp.470-478, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00145547

K. Yoshiyama, Y. Higuchi, M. Kataoka, K. Matsuura, and S. Yamamoto, CD156 (human ADAM8): expression, primary amino acid sequence, and gene location, Genomics, vol.41, pp.56-62, 1997.

J. L. Zhong, Z. Poghosyan, C. J. Pennington, X. Scott, M. M. Handsley et al., Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma, Mol Cancer Res, vol.6, pp.383-394, 2008.