B. Ahlemeyer, S. Halupczok, E. Rodenberg-frank, K. Valerius, and E. Baumgart-vogt, Endogenous murine amyloid-? peptide assembles into aggregates in the aged C57BL/6J mouse suggesting these animals as a model to study pathogenesis of amyloid-? plaque formation, J Alzheimers Dis, vol.61, issue.4, pp.1425-1450, 2018.

, Recommandations et perspectives pour une surveillance nationale de la contamination de l'air par les pesticides. Synthèse et recommandations du comité d'orientation et de prospective scientifique de l'observatoire des résidus de pesticides (ORP), p.29, 2010.

A. , Report 2. Pesticide residues, additives, acrylamide and polycyclic aromatic hydrocarbons. ANSES Opinion, p.29, 2011.

A. , Evaluation des risques liés aux résidus de pesticides dans l'eau de distribution. Contribution à l'exposition alimentaire totale. Rapport d'étude scientifique, p.29, 2013.

M. Arango-lievano, P. Giannoni, S. Claeysen, N. Marchi, and F. Jeanneteau, Longitudinal in vivo imaging of the cerebrovasculature: relevance to CNS diseases, J Vis Exp, vol.118, p.54796, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01792491

L. Araujo, M. E. Troconis, D. Cubillán, J. Mercado, N. Villa et al., Single drop microextraction and gas chromatography-mass spectrometry for the determination of diflufenican, mepanipyrim, fipronil, and pretilachlor in water samples, Environ Monit Assess, vol.185, issue.12, pp.10225-10233, 2013.

A. Bermúdez-couso, M. Arias-estévez, J. C. Nóvoa-muñoz, E. López-periago, B. Soto-gonzález et al., Seasonal distributions of fungicides in soils and sediments of a small river basin partially devoted to vineyards, Water Res, vol.41, issue.19, pp.4515-4525, 2007.

S. A. Bustin, V. Benes, J. A. Garson, J. Hellemans, J. Huggett et al., The MIQE guidelines: Minimum Information for publication of Quantitative real-time PCR Experiments, Clin Chem, vol.55, issue.4, pp.611-622, 2009.

H. Cai, Y. Wang, D. Mccarthy, H. Wen, D. R. Borchelt et al., BACE1 is the major ?-secretase for generation of A? peptides by neurons, Nat Neurosci, vol.4, issue.3, pp.233-234, 2001.

M. Cam, E. Durieu, M. Bodin, A. Manousopoulou, S. Koslowski et al., Induction of amyloid-?42 production by fipronil and other pyrazole insecticides, J Alzheimers Dis, vol.62, issue.4, pp.1663-1681, 2018.

C. M. Carroll and Y. Li, Physiological and pathological roles of the ?-secretase complex, Brain Res Bull, vol.126, pp.199-206, 2016.

L. Chami and F. Checler, BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and ?-amyloid production in Alzheimer's disease, Mol Neurodegener, vol.7, p.52, 2012.

L. Chen, S. Yoo, N. R. Liu, Y. Ran, and Q. , Cognitive impairment and increased A? levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H 2 O 2, Neurobiol Aging, vol.33, issue.2, 2012.

M. Chin-chan, J. Segovia, L. Quintanar, T. Arcos-lópez, L. B. Hersh et al., Mercury reduces the enzymatic activity of neprilysin in differentiated SH-SY5Y cells, Toxicol Sci, vol.145, issue.1, pp.128-137, 2015.

M. J. Climent, M. J. Sánchez-martín, M. S. Rodríguez-cruz, P. Pedreros, R. Urritia et al., Determination of pesticides in river surface waters of central Chile using SPE-GC-MS multi-residue method, J Chil Chem Soc, vol.63, issue.2, pp.4023-4031, 2018.

, Council directive 98/83EC of 3 November 1998 on the quality of water for human consumption, Off J Eur Communities L, vol.330, pp.32-54, 1998.

J. G. Cronin, V. Kanamarlapudi, C. A. Thornton, and I. M. Sheldon, Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells, Mucosal Immunol, vol.9, issue.5, pp.1125-1136, 2016.

M. Désert, S. Ravier, G. Gille, A. Quinapallo, A. Armengaud et al., Spatial and temporal distribution of current-use pesticides in ambient air of, Atmos Environ, vol.192, pp.241-256, 2018.

B. E. Deverman and P. H. Patterson, Cytokines and CNS development, Cell, vol.64, issue.1, pp.61-78, 2009.

, Conclusion regarding the peer review of the pesticide risk assesment of the active substance cyprodinil, EFSA J, vol.4, issue.1, 2006.

. Efsa, Conclusion regarding the peer review of the pesticide risk assessment of the active substance pyrimethanil, EFSA J, vol.4, issue.2, p.61, 2006.

. Efsa, Review of the existing maximum residue levels (MRLs) for mepanipyrim according to Article 12 of Regulation (EC) No 396, EFSA J, vol.9, issue.8, p.2342, 2005.

. Efsa, Peer review of the pesticide risk assessment of the active substance mepanipyrim, EFSA J, vol.15, issue.6, p.4852

. Efsa, The 2015 European Union report on pesticide residues in food, EFSA J, vol.15, issue.4, p.4791

, The 2016 European Union report on pesticide residues in food, EFSA J, vol.16, issue.7, p.5348, 2018.

. Efsa, European Union report on pesticide residues in food, EFSA J, vol.17, issue.6, p.5743, 2017.

L. F. Eng, A. C. Yu, and Y. L. Lee, Astrocytic response to injury, Prog Brain Res, vol.94, pp.61764-61765, 1992.

F. A. Esteve-turrillas, C. Agulló, A. Abad-fuentes, A. Abad-somovilla, and J. V. Mercader, Immunoreagent generation and competitive assay development for cyprodinil analysis, J Agric Food Chem, vol.60, issue.19, pp.4803-4811, 2012.

F. A. Esteve-turrillas, J. V. Mercader, C. Agulló, A. Abad-somovilla, and A. Abad-fuentes, Mepanipyrim haptens and antibodies with nanomolar affinity, Analyst, vol.138, issue.12, pp.3360-3364, 2013.

. Fao, Cyprodinil: a first draft prepared by David Hamilton, FAO reports, p.29, 2003.

. Fao, Pyrimethanil (226): a first draft prepared by Stephen Funk, FAO reports, p.29, 2007.

B. Fathabadi, M. Dehghanifiroozabadi, J. Aaseth, G. Sharifzadeh, S. Nakhaee et al., Comparison of blood lead levels in patients with Alzheimer's disease and healthy people, Am J Alzheimers Dis Other Demen, vol.33, issue.8, pp.541-547, 2018.

, Enquête EXPPERT II: des pesticides interdits et des perturbateurs endocriniens (PE) dans des fraises, Générations Futures, p.29, 2013.

, Enquête EXPPERT 7: des pesticides perturbateurs endocriniens dans des mueslis, Générations Futures, p.29, 2016.

, Enquête EXPPERT 6 (analyse des poussières): des riverains de zones cultivées exposés aux pesticides perturbateurs endocriniens chez eux, tout au long de l'année, Générations Futures, p.29, 2016.

, Enquête EXPPERT 9: exposition aux perturbateurs endocriniens, 7 personnalités de l'écologie font analyser leurs cheveux, p.29, 2017.

P. Giannoni, M. Arango-lievano, I. D. Neves, M. Rousset, K. Baranger et al., Cerebrovascular pathology during the progression of experimental Alzheimer's disease, Neurobiol Dis, vol.88, pp.107-117, 2016.

H. Gu, X. Wei, A. D. Monnot, C. V. Fontanilla, M. Behl et al., Lead exposure increases levels of ?-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice, Neurosci Lett, vol.490, issue.1, pp.16-20, 2011.

T. Hama, M. Miyamoto, H. Tsukui, C. Nishio, and H. Hatanaka, Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats, Neurosci Lett, vol.104, issue.3, pp.90600-90609, 1989.

K. M. Hayden, M. C. Norton, D. D. Ostbye, T. Zandi, P. P. Breitner et al., Occupational exposure to pesticides increases the risk of incident AD: the Cache County study, Neurology, vol.74, pp.1524-1530, 2010.

E. Herrero-hernández, E. Pose-juan, M. J. Sánchez-martín, M. S. Andrades, and R. Ms, Intra-annual trends of fungicide residues in waters from vineyard areas in La Rioja region of northern Spain, Environ Sci Pollut Res Int, vol.23, issue.22, pp.22924-22936, 2016.

H. Huang, S. W. Bihaqi, L. Cui, and N. H. Zawia, In vitro Pb exposure disturbs the balance between A? production and elimination: the role of A?PP and neprilysin, Neurotoxicology, vol.32, issue.3, pp.300-306, 2011.

D. Ito, Y. Imai, K. Ohsawa, K. Nakajima, Y. Fukuuchi et al., Microglia-specific localisation of a novel calcium binding protein, Iba1, Brain Res Mol Brain Res, vol.57, issue.1, pp.40-40, 1998.

T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina et al., Visualization of A?42(43) and A?40 in senile plaques with end-specific A? monoclonals: evidence that an initially deposited species is A?42(43), Neuron, vol.13, issue.1, pp.45-53, 1994.

A. Jain, S. Kaczanowska, and E. Davila, IL-1 receptor-associated kinase signaling and its role in inflammation, cancer progression, and therapy resistance, Front Immunol, vol.5, p.553, 2014.

D. E. Kang, C. U. Pietrzik, L. Baum, N. Chevallier, D. E. Merriam et al., Modulation of amyloid ?-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway, J Clin Invest, vol.106, issue.9, pp.1159-1166, 2000.

M. Kawahara, M. Kato, and Y. Kuroda, Effects of aluminum on the neurotoxicity of primary cultured neurons and on the aggregation of ?-amyloid protein, Brain Res. Bull, vol.55, issue.2, pp.211-217, 2001.

D. Kim, J. Park, and B. Choi, Mercury-induced amyloid-beta (A?) accumulation in the brain is mediated by disruption of A? transport, J Toxicol Sci, vol.39, issue.4, pp.625-635, 2014.

I. F. Kimbrough, S. Robel, E. D. Roberson, and H. Sontheimer, Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer's disease, Brain, vol.138, pp.3716-3733, 2015.

P. Lafon, T. Imberdis, Y. Wang, J. Torrent, M. Robitzer et al., Low doses of bioherbicide favour prion aggregation and propagation in vivo, Sci. Rep, vol.8, issue.1, p.8023, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-02333903

C. Lukowicz, S. Ellero-simatos, M. Régnier, A. Polizzi, F. Lasserre et al., Metabolic effects of a chronic dietary exposure to a low-dose pesticide cocktail in mice: sexual dimorphism and role of the constitutive androstane receptor, Environ Health Perspect, vol.126, issue.6, p.67007, 2018.

Y. Luo, B. Bolon, B. D. Bennett, S. Babu-khan, P. Denis et al., Mice deficient in BACE1, the Alzheimer's ?-secretase, have normal phenotype and abolished ?-amyloid generation, Nat Neurosci, vol.4, issue.3, pp.231-232, 2001.

M. Mansuy, S. Baille, G. Canet, A. Borie, C. Cohen-solal et al., Deletion of plasma Phospholipid Transfer Protein (PLTP) increases microglial phagocytosis and reduces cerebral amyloid-? deposition in the J20 mouse model of Alzheimer's disease, Oncotarget, vol.9, issue.28, pp.19688-19703, 2018.

J. V. Mercader, F. A. Esteve-turrillas, C. Agulló, A. Abad-somovilla, and A. Abad-fuentes, Antibody generation and immunoassay development in diverse formats for pyrimethanil specific and sensitive analysis, Analyst, vol.137, issue.23, pp.5672-5679, 2012.

J. S. Miners, S. Baig, H. Tayler, P. G. Kehoe, and S. Love, Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity, 2009.

, J Neuropathol Exp Neurol, vol.68, issue.8, pp.902-914

J. S. Miners, Z. Van-helmond, K. Chalmers, G. Wilcock, S. Love et al., Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy, J Neuropathol Exp Neurol, vol.65, issue.10, pp.1012-1021, 2006.

L. Mucke, E. Masliah, G. Q. Yu, M. Mallory, E. M. Rockenstein et al., Highlevel neuronal expression of A? 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation, J Neurosci, vol.20, issue.11, pp.4050-4058, 2000.

T. Mura, J. Dartigues, C. Berr, A. Nasri, A. J. Valverde et al., How many dementia cases in France and Europe? Alternative projections and scenarios 2010-2050, Int J Mol Sci, vol.17, issue.2, p.2137, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00426844

R. J. O'brien and P. C. Wong, Amyloid precursor protein processing and Alzheimer's disease, Annu Rev Neurosci, vol.34, pp.185-204, 2011.

, Care Needed: Improving the Lives of People with Dementia. OECD Health Policy Studies, 2018.

, Etude vin de PAN-Europe/MDRGF. Etude sur la présence de résidus de pesticides dans le vin, p.29, 2008.

E. Portelius, E. Durieu, M. Bodin, C. M. Pannee, J. Leuxe et al., Specific triazine herbicides induce amyloid-?42 production, J Alzheimers Dis, vol.54, issue.4, pp.1593-1605, 2016.

Z. Qiu and D. L. Gruol, Interleukin-6, ?-amyloid peptide and NMDA interactions in rat cortical neurons, J Neuroimmunol, vol.139, pp.158-167, 2003.

R. Rial-otero, R. M. González-rodríguez, B. Cancho-grande, and J. Simal-gándara, Parameters affecting extraction of selected fungicides from vineyard soils, J Agric Food Chem, vol.52, issue.24, pp.7227-7234, 2004.

J. R. Richardson, A. Roy, S. L. Shalat, V. Stein, R. T. Hossain et al., Elevated serum pesticide levels and risk for Alzheimer disease, JAMA Neurol, vol.71, issue.3, pp.284-290, 2014.

J. G. Salazar, D. Ribes, M. Cabré, J. L. Domingo, F. Sanchez-santed et al., Amyloid ? peptide levels increase in brain of A?PP Swedish mice after exposure to chlorpyrifos, Curr Alzheimer Res, vol.8, issue.7, pp.732-740, 2011.

M. Serra-batiste, M. Ninot-pedrosa, M. Bayoumi, M. Gairí, G. Maglia et al., A?42 assembles into specific ?-barrel pore-forming oligomers in membranemimicking environments, Proc Natl Acad Sci, vol.113, issue.39, pp.10866-10871, 2016.

A. Serrano-pozo, M. L. Mielke, T. Gómez-isla, R. A. Betensky, J. H. Growdon et al., Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease, Am J Pathol, vol.179, issue.3, pp.1373-1384, 2011.

J. Shi, G. Perry, M. A. Smith, and R. P. Friedland, Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease, Neurobiol Aging, vol.21, issue.2, pp.119-125, 2000.

J. Shi and S. Sun, Tumor necrosis factor receptor-associated factor regulation of nuclear factor ?B and mitogen-activated protein kinase pathways, Front Immunol, vol.9, p.1849, 2018.

M. Shinohara, S. Fujioka, M. E. Murray, A. Wojtas, M. Baker et al., Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease, Brain, vol.137, pp.1533-1549, 2014.

P. Thornton, E. Pinteaux, R. M. Gibson, S. M. Allan, and N. J. Rothwell, Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release, J Neurochem, vol.98, issue.1, pp.258-266, 2006.

J. R. Walton and M. Wang, APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease, J Inorg Biochem, vol.103, issue.11, pp.1548-1554, 2009.

A. L. Wright, R. Zinn, B. Hohensinn, L. M. Konen, S. B. Beynon et al., Neuroinflammation and neuronal loss precede A? plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease, PLoS One, vol.8, issue.4, p.59586, 2013.

L. Xu, W. Zhang, X. Liu, C. Zhang, P. Wang et al., Circulatory levels of toxic metals (aluminum, cadmium, mercury, lead) in patients with Alzheimer's disease: a quantitative meta-analysis and systematic review, J Alzheimers Dis, vol.62, issue.1, pp.361-372, 2018.

S. Yoon and S. Ahnjo, Mechanisms of amyloid-? peptide clearance: potential therapeutic targets for Alzheimer's disease, Biomol Ther (Seoul), vol.20, issue.3, pp.245-255, 2012.

Z. Zhao, Z. Xiang, V. Haroutunian, J. D. Buxbaum, B. Stetka et al., Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease, Neurobiol Aging, vol.28, issue.6, pp.824-830, 2007.