D. C. Angus and T. Van-der-poll, Severe sepsis and septic shock, N Engl J Med, vol.369, pp.840-51, 2013.

O. V. Hein, K. Misterek, J. Tessmann, V. Van-dossow, M. Krimphove et al., Time course of endothelial damage in septic shock: prediction of outcome, Crit Care Lond Engl, vol.9, pp.323-353, 2005.

C. Nedeva, J. Menassa, and H. Puthalakath, Sepsis: inflammation is a necessary evil, Front Cell Dev Biol, vol.7, p.108, 2019.

P. Thiebaut, M. Besnier, E. Gomez, and V. Richard, Role of protein tyrosine phosphatase 1B in cardiovascular diseases, J Mol Cell Cardiol, vol.101, pp.50-57, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02296621

J. M. Zabolotny, Y. Kim, L. A. Welsh, E. E. Kershaw, B. G. Neel et al., Proteintyrosine phosphatase 1B expression is induced by inflammation in vivo, J Biol Chem, vol.283, pp.14230-14271, 2008.

D. Coquerel, R. Neviere, E. Delile, P. Mulder, X. Marechal et al., Gene deletion of protein tyrosine phosphatase 1B protects against sepsisinduced cardiovascular dysfunction and mortality, Arterioscler Thromb Vasc Biol, vol.34, pp.1032-1076, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-02296639

S. Hagiwara, H. Iwasaka, A. Hasegawa, N. Asai, and T. Noguchi, Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model, Crit Care Med, vol.37, pp.2223-2230, 2009.

D. Bar-or, L. T. Rael, R. M. Madayag, K. L. Banton, A. I. Tanner et al., Stress Hyperglycemia in critically ill patients: insight into possible molecular pathways, Front Med, vol.6, p.54, 2019.

E. Delile, R. Nevière, P. Thiébaut, J. Maupoint, P. Mulder et al., Reduced insulin resistance contributes to the beneficial effect of protein tyrosine phosphatase-1B deletion in a mouse model of sepsis, vol.48, pp.355-63, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01835344

M. M. Khan, W. Yang, and P. Wang, Endoplasmic reticulum stress in sepsis, Shock, vol.44, pp.294-304, 2015.

E. Panzhinskiy, Y. Hua, B. Culver, J. Ren, and S. Nair, Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes, Diabetologia, vol.56, pp.598-607, 2013.

S. Wang, X. Chen, S. Nair, D. Sun, X. Wang et al., Deletion of protein tyrosine phosphatase 1B obliterates endoplasmic reticulum stress-induced myocardial dysfunction through regulation of autophagy, Biochim Biophys Acta Mol Basis Dis, vol.1863, pp.3060-74, 2017.

P. Thiebaut, E. Delile, D. Coquerel, J. Brunel, S. Renet et al., Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction, Vascul Pharmacol, vol.109, pp.36-44, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-02296610

H. Hu, M. Tian, C. Ding, and S. Yu, The C/EBP Homologous Protein (CHOP) transcription factor functions in endoplasmic reticulum stressinduced apoptosis and microbial infection, Front Immunol, vol.9, p.83, 2019.

T. Ma, L. Han, Y. Gao, L. Li, X. Shang et al., The endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsisinduced abnormal lymphocyte apoptosis, Eur Surg Res Eur Chir Forsch Rech Chir Eur, vol.41, pp.219-244, 2008.

H. J. Kim, J. S. Jeong, S. R. Kim, S. Y. Park, H. J. Chae et al., Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-?B/HIF-1? signaling pathway, Sci Rep, vol.3, p.1142, 2013.

J. Grootjans, A. Kaser, R. J. Kaufman, and R. S. Blumberg, The unfolded protein response in immunity and inflammation, Nat Rev Immunol, vol.16, pp.469-84, 2016.

L. Liu, H. Wu, J. Zang, G. Yang, Y. Zhu et al., 4-phenylbutyric acid reveals good beneficial effects on vital organ function via antiendoplasmic reticulum stress in septic rats, Crit Care Med, vol.44, pp.689-701, 2016.

M. Yan, S. Shu, C. Guo, C. Tang, and Z. Dong, Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury, Ann Med, vol.50, pp.381-90, 2018.

R. P. Dellinger, M. M. Levy, A. Rhodes, D. Annane, H. Gerlach et al., Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, Intensive Care Med, vol.39, pp.165-228, 2012.

M. Cummings, J. Sarveswaran, S. Homer-vanniasinkam, D. Burke, and N. M. Orsi, Glyceraldehyde-3-phosphate dehydrogenase is an inappropriate housekeeping gene for normalising gene expression in sepsis, Inflammation, vol.37, pp.1889-94, 2014.

M. Feldhammer, N. Uetani, D. Miranda-saavedra, and M. L. Tremblay, PTP1B: a simple enzyme for a complex world, Crit Rev Biochem Mol Biol, vol.48, pp.430-475, 2013.

L. Yue, Z. Xie, H. Li, Z. Pang, R. D. Junkins et al., Protein tyrosine phosphatase-1B negatively impacts host defense against Pseudomonas aeruginosa infection, Am J Pathol, vol.186, pp.1234-1278, 2016.

J. Lyu, G. Zheng, Z. Chen, B. Wang, S. Tao et al., Sepsisinduced brain mitochondrial dysfunction is associated with altered mitochondrial Src and PTP1B levels, Brain Res, vol.1620, pp.130-138, 2015.

Y. Wang, F. Yan, W. Zhang, S. Pang, and F. Jiang, Inhibiting protein tyrosine phosphatase 1B to improve regenerative functions of endothelial cells, J Cardiovasc Pharmacol, vol.71, pp.59-64, 2018.

X. Shao, J. Li, Y. Wang, Q. Liang, and S. Song, Expression and its correlation with metabolic syndrome of protein tyrosine phosphatase 1B in serum of polycystic ovary syndrome patients, Biomed Res, vol.28, issue.6, 2017.

X. Zhang, J. Tian, J. Li, L. Huang, S. Wu et al., A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance, Br J Pharmacol, vol.173, pp.1939-1988, 2016.

A. Koch, O. A. Gressner, E. Sanson, F. Tacke, and C. Trautwein, Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients, Crit Care Lond Engl, vol.13, p.95, 2009.

C. Von-loeffelholz, D. Thomas-rüddel, M. Bauer, and A. Birkenfeld, Effect of magnesium loading dose on insulin resistance in patients with stress-induced hyperglycemia: a randomized clinical trial, J Intensive Care Med, 2018.

N. Egawa, K. Yamamoto, H. Inoue, R. Hikawa, K. Nishi et al., The endoplasmic reticulum stress sensor, ATF6?, protects against neurotoxininduced dopaminergic neuronal death, J Biol Chem, vol.286, pp.7947-57, 2011.

J. Wu, D. T. Rutkowski, M. Dubois, J. Swathirajan, T. Saunders et al., ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress, Dev Cell, vol.13, pp.351-64, 2007.

S. Doroudgar, D. J. Thuerauf, M. C. Marcinko, P. J. Belmont, and C. C. Glembotski, Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response, J Biol Chem, vol.284, pp.29735-29780, 2009.

L. Diao, A. H. Marshall, X. Dai, E. Bogdanovic, A. Abdullahi et al., Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1? in liver, Shock, vol.41, pp.138-182, 2014.

N. I. Shapiro, P. Schuetz, K. Yano, M. Sorasaki, S. M. Parikh et al., The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis, Crit Care Lond Engl, vol.14, p.182, 2010.

S. Skibsted, A. E. Jones, M. A. Puskarich, R. Arnold, R. Sherwin et al., Biomarkers of endothelial cell activation in early sepsis, Shock, vol.39, pp.427-459, 2013.

O. Lundberg, L. Bergenzaun, J. Rydén, M. Rosenqvist, O. Melander et al., Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients, Crit Care Lond Engl, vol.20, p.178, 2016.

E. P. Rivers, J. A. Kruse, G. Jacobsen, K. Shah, M. Loomba et al., The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock, Crit Care Med, vol.35, pp.2016-2040, 2007.

S. Mckenna, M. Gossling, A. Bugarini, E. Hill, A. L. Anderson et al., Endotoxemia induces I?B?/NF-?B-dependent endothelin-1 expression in hepatic macrophages, J Immunol Baltim Md, vol.195, pp.3866-79, 1950.

Y. Luo, S. Li, Y. J. Qiu, Y. Chen, and F. , HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway, Biochem Biophys Res Commun, vol.438, pp.732-740, 2013.

J. Vincent, G. Jones, S. David, E. Olariu, and K. K. Cadwell, Frequency and mortality of septic shock in Europe and North America: a systematic review and metaanalysis, Crit Care Lond Engl, vol.23, p.196, 2019.

E. K. Stevenson, A. R. Rubenstein, G. T. Radin, R. S. Wiener, and A. J. Walkey, Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis *, Crit Care Med, vol.42, pp.625-656, 2014.

X. Qiang, Y. Li, Y. Zhou, and L. , Prognosis risk of urosepsis in critical care medicine: a prospective observational study, BioMed Res Int, p.9028924, 2016.

E. Tampakakis, C. E. Tabit, M. Holbrook, E. A. Linder, B. D. Berk et al., Intravenous lipid infusion induces endoplasmic reticulum stress in endothelial cells and blood mononuclear cells of healthy adults, J Am Heart Assoc, vol.5, p.2574, 2016.

A. J. Stull, Z. Q. Wang, X. H. Zhang, Y. Yu, W. D. Johnson et al., Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans, Diabetes, vol.61, pp.1415-1437, 2012.

R. J. Feezor, H. V. Baker, M. Mindrinos, D. Hayden, C. L. Tannahill et al., Whole blood and leucocyte RNA isolation for gene expression analyses, Physiol Genomics, vol.19, pp.247-54, 2004.

J. S. So, Roles of endoplasmic reticulum stress in immune responses, Mol Cells, vol.41, pp.705-721, 2018.

Y. Ma, Y. Shimizu, M. J. Mann, Y. Jin, and L. M. Hendershot, Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERKdependent branch of the unfolded protein response, Cell Stress Chaperones, vol.15, pp.281-93, 2010.

T. E. Sweeney and P. Khatri, Benchmarking sepsis gene expression diagnostics using public data *, Crit Care Med, vol.45, pp.1-10, 2017.

W. Xiao, M. N. Mindrinos, J. Seok, J. Cuschieri, A. G. Cuenca et al., A genomic storm in critically injured humans, J Exp Med, vol.208, pp.2581-90, 2011.

B. P. Scicluna, L. A. Van-vught, A. H. Zwinderman, M. A. Wiewel, E. E. Davenport et al., Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study, Lancet Respir Med, vol.5, issue.17, pp.30294-30295, 2017.