H. D. Klepin, A. V. Rao, and T. S. Pardee, Acute myeloid leukemia and myelodysplastic syndromes in older adults, Journal of Clinical Oncology, vol.32, issue.24, pp.2541-2552, 2014.

D. H. Wiseman, M. Das, K. Poulton, and E. Liakopoulou, Donor cell leukemia following unrelated donor bone marrow transplantation for primary granulocytic sarcoma of the small intestine, American Journal of Hematology, vol.86, issue.3, pp.315-318, 2011.

B. Hertenstein, L. Hambach, and A. Bacigalupo, Development of leukemia in donor cells after allogeneic stem cell transplantation-a survey of the European Group for Blood and Marrow Transplantation (EBMT), Haematologica, issue.7, pp.969-975, 2005.

Y. W. Kim, B. K. Koo, and H. W. Jeong, Defective Notch activation in microenvironment leads to myeloproliferative disease, Blood, vol.112, issue.12, pp.4628-4638, 2008.

A. Kode, J. S. Manavalan, and I. Mosialou, Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts, Nature, vol.506, issue.7487, pp.240-244, 2014.

M. H. Raaijmakers, S. Mukherjee, and S. Guo, Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia, Nature, vol.464, issue.7290, pp.852-857, 2010.

S. J. Morrison and D. T. Scadden, The bone marrow niche for haematopoietic stem cells, Nature, issue.7483, pp.327-334, 2014.

R. Hass and A. Otte, Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment, Cell Communication & Signaling, vol.10, issue.1, p.26, 2012.

B. Sacchetti, A. Funari, and S. Michienzi, Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment, Cell, vol.131, issue.2, pp.324-336, 2007.

T. Sugiyama, H. Kohara, M. Noda, and T. Nagasawa, Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches, Immunity, vol.25, issue.6, pp.977-988, 2006.

S. Mendez-ferrer, T. V. Michurina, and F. Ferraro, Mesenchymal and haematopoietic stem cells form a unique bone marrow niche, Nature, vol.466, issue.7308, pp.829-834, 2010.

Y. Kunisaki, I. Bruns, and C. Scheiermann, Arteriolar niches maintain haematopoietic stem cell quiescence, Nature, vol.502, issue.7473, pp.637-643, 2013.

L. Ding, T. L. Saunders, G. Enikolopov, and S. J. Morrison, Endothelial and perivascular cells maintain haematopoietic stem cells, Nature, issue.7382, pp.457-462, 2012.

M. Ogawa, Y. Matsuzaki, and S. Nishikawa, Expression and function of c-kit in hemopoietic progenitor cells, Journal of Experimental Medicine, vol.174, issue.1, pp.63-71, 1991.

S. L. Ellis, J. Grassinger, and A. Jones, The relationship between bone, hemopoietic stem cells, and vasculature, Blood, vol.118, issue.6, pp.1516-1524, 2011.

O. Naveiras, V. Nardi, P. L. Wenzel, P. V. Hauschka, F. Fahey et al., Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment, Nature, vol.460, issue.7252, pp.259-263, 2009.

H. Medyouf, M. Mossner, and J. C. Jann, Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit, Cell Stem Cell, vol.14, issue.6, pp.824-837, 2014.

M. Hanoun, D. Zhang, and T. Mizoguchi, Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche, Cell Stem Cell, vol.15, issue.3, pp.365-375, 2014.

L. Arranz, A. Sánchez-aguilera, and D. Martín-pérez, Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms, Nature, vol.512, issue.7512, pp.78-81, 2014.

S. Geyh, S. Oz, and R. P. Cadeddu, Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells, Leukemia, vol.27, issue.9, pp.1841-1851, 2013.

Z. G. Zhao, Y. Liang, and K. Li, Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases, Stem Cells and Development, vol.16, issue.4, pp.637-648, 2007.

P. Chandran, Y. Le, and Y. Li, Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors, Leukemia Research, vol.39, issue.4, pp.486-493, 2015.

M. Dominici, K. Le-blanc, and I. Mueller, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, vol.8, issue.4, pp.315-317, 2006.

V. L. Battula, Y. Chen, and G. Cabreira-mda, Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment, Blood, vol.122, issue.3, pp.357-366, 2013.

A. Sorrentino, M. Ferracin, and G. Castelli, Isolation and characterization of CD146 + multipotent mesenchymal stromal cells, Experimental Hematology, vol.36, issue.8, pp.1035-1046, 2008.

S. Valastyan and R. A. Weinberg, Roles for microRNAs in the regulation of cell adhesion molecules, Journal of Cell Science, vol.124, issue.7, pp.999-1006, 2011.

P. J. Mishra, P. J. Mishra, and R. Humeniuk, Carcinomaassociated fibroblast-like differentiation of human mesenchymal stem cells, Cancer Research, vol.68, issue.11, pp.4331-4339, 2008.

A. Colmone, M. Amorim, A. L. Pontier, S. Wang, E. Jablonski et al., Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells, Science, vol.322, issue.5909, pp.1861-1865, 2008.

H. Y. Kim, Y. S. Oh, and I. C. Song, Endogenous stromal cell-derived factor-1 (CXCL12) supports autonomous growth of acute myeloid leukemia cells, Leukemia Research, vol.37, issue.5, pp.566-572, 2013.

S. Konoplev, G. Z. Rassidakis, and E. Estey, Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype, Cancer, vol.109, issue.6, pp.1152-1156, 2007.

M. Crisan, S. Yap, and L. Casteilla, A perivascular origin for mesenchymal stem cells in multiple human organs, Cell Stem Cell, vol.3, issue.3, pp.301-313, 2008.