B. Dahlback, The tale of protein S and C4b-binding protein, a story of affection. Thromb Haemost, vol.98, pp.90-96, 2007.

F. Saller, B. O. Villoutreix, and A. Amelot, The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding, Blood, vol.105, issue.1, pp.122-130, 2005.

C. Van't-veer, T. M. Hackeng, D. Biesbroeck, J. J. Sixma, and B. N. Bouma, Increased prothrombin activation in protein S-deficient plasma under flow conditions on endothelial cell matrix: an independent anticoagulant function of protein S in plasma, Blood, vol.85, issue.7, pp.1815-1821, 1995.

T. Burstyn-cohen, M. J. Heeb, and G. Lemke, Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis, J Clin Invest, vol.119, issue.10, pp.2942-2953, 2009.

P. Garcia-de-frutos, P. Fuentes-prior, B. Hurtado, and N. Sala, Molecular basis of protein S deficiency, Thromb Haemost, vol.98, issue.3, pp.543-556, 2007.

D. S. Fair and R. A. Marlar, Biosynthesis and secretion of factor VII, protein C, protein S, and the protein C inhibitor from a human hepatoma cell line, Blood, vol.67, issue.1, pp.64-70, 1986.

G. Lemke and C. V. Rothlin, Immunobiology of the TAM receptors, Nat Rev Immunol, vol.8, issue.5, pp.327-336, 2008.

D. S. Fair, R. A. Marlar, and E. G. Levin, Human endothelial cells synthesize protein S, Blood, vol.67, issue.4, pp.1168-1171, 1986.

O. Benzakour and C. Kanthou, The anticoagulant factor, protein S, is produced by cultured human vascular smooth muscle cells and its expression is up-regulated by thrombin, Blood, vol.95, issue.6, pp.2008-2014, 2000.

T. N. Stitt, G. Conn, and M. Gore, The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases, Cell, vol.80, issue.4, pp.661-670, 1995.

C. V. Rothlin, S. Ghosh, E. I. Zuniga, M. B. Oldstone, and G. Lemke, TAM receptors are pleiotropic inhibitors of the innate immune response, Cell, vol.131, issue.6, pp.1124-1136, 2007.

M. O. Hall, M. S. Obin, M. J. Heeb, B. L. Burgess, and T. A. Abrams, Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells, Exp Eye Res, vol.81, issue.5, pp.581-591, 2005.

D. Liao, X. Wang, M. Li, P. H. Lin, Q. Yao et al., Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages, Blood, vol.113, issue.1, pp.165-174, 2009.

D. Zhu, Y. Wang, and I. Singh, Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor, Blood, vol.115, issue.23, pp.4963-4972, 2010.

H. Guo, T. M. Barrett, and Z. Zhong, Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartatetreated neurons via Tyro3-Akt-FKHRL1 signaling pathway, Mol Neurodegener, vol.6, p.13, 2011.

D. Prasad, C. V. Rothlin, and P. Burrola, TAM receptor function in the retinal pigment epithelium, Mol Cell Neurosci, vol.33, issue.1, pp.96-108, 2006.

H. A. Anderson, C. A. Maylock, J. A. Williams, C. P. Paweletz, H. Shu et al., Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells, Nat Immunol, vol.4, issue.1, pp.87-91, 2003.

M. Tjwa, L. Bellido-martin, and Y. Lin, Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes, Blood, vol.111, issue.8, pp.4096-4105, 2008.

G. Collett, A. Wood, and M. Y. Alexander, Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes, Circ Res, vol.92, issue.10, pp.1123-1129, 2003.

M. G. Melaragno, D. A. Wuthrich, and V. Poppa, Increased expression of Axl tyrosine kinase after vascular injury and regulation by G proteincoupled receptor agonists in rats, Circ Res, vol.83, issue.7, pp.697-704, 1998.

P. Carmeliet, Mechanisms of angiogenesis and arteriogenesis, Nat Med, vol.6, issue.4, pp.389-395, 2000.

R. K. Jain, Molecular regulation of vessel maturation, Nat Med, vol.9, issue.6, pp.685-693, 2003.

N. Ferrara, H. P. Gerber, and J. Lecouter, The biology of VEGF and its receptors, Nat Med, vol.9, issue.6, pp.669-676, 2003.

Q. Hao, L. Wang, Z. J. Zhao, and H. Tang, Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis, J Biol Chem, vol.284, issue.2, pp.799-806, 2009.

L. Chen, S. S. Sung, and M. L. Yip, Discovery of a novel shp2 protein tyrosine phosphatase inhibitor, Mol Pharmacol, vol.70, issue.2, pp.562-570, 2006.

K. Watanabe, Y. Hasegawa, and H. Yamashita, Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis, J Clin Invest, vol.114, issue.7, pp.898-907, 2004.

K. Grote, H. Schuett, and G. Salguero, Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration, Blood, vol.115, issue.12, pp.2543-2552, 2010.

A. J. Primeau, A. Rendon, D. Hedley, L. Lilge, and I. F. Tannock, The distribution of the anticancer drug doxorubicin in relation to blood vessels in solid tumors, Clin Cancer Res, vol.11, issue.24, pp.8782-8788, 2005.

M. Gallicchio, S. Mitola, and D. Valdembri, Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor, Blood, vol.105, issue.5, pp.1970-1976, 2005.

A. Niemisto, V. Dunmire, O. Yli-harja, W. Zhang, and I. Shmulevich, Robust quantification of in vitro angiogenesis through image analysis, IEEE Trans Med Imaging, vol.24, issue.4, pp.549-553, 2005.

A. K. Olsson, A. Dimberg, J. Kreuger, C. , and L. , VEGF receptor signalling: in control of vascular function, Nat Rev Mol Cell Biol, vol.7, issue.5, pp.359-371, 2006.

S. Rousseau, F. Houle, and J. Huot, Integrating the VEGF signals leading to actin-based motility in vascular endothelial cells, Trends Cardiovasc Med, vol.10, issue.8, pp.321-327, 2000.

S. Goetze, F. Eilers, and A. Bungenstock, PPAR activators inhibit endothelial cell migration by targeting Akt, Biochem Biophys Res Commun, vol.293, issue.5, pp.1431-1437, 2002.

S. Sinha, P. K. Vohra, R. Bhattacharya, S. Dutta, S. Sinha et al., Dopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2, J Cell Sci, vol.122, issue.18, pp.3385-3392, 2009.

L. Sylvest, C. D. Bendiksen, and G. Houen, Phosphatase inhibitors with anti-angiogenic effect in vitro. Apmis, vol.118, pp.49-59, 2010.

Q. Lu and G. Lemke, Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family, Science, vol.293, issue.5528, pp.306-311, 2001.

D. Stern, J. Brett, K. Harris, and P. Nawroth, Participation of endothelial cells in the protein C-protein S anticoagulant pathway: the synthesis and release of protein S, J Cell Biol, vol.102, issue.5, pp.1971-1978, 1986.

A. Wimmel, I. Rohner, and A. Ramaswamy, Synthesis and secretion of the anticoagulant protein S and coexpression of the Tyro3 receptor in human lung carcinoma cells, Cancer, vol.86, issue.1, pp.43-49, 1999.

E. Sierko, M. Z. Wojtukiewicz, R. Zawadzki, L. Zimnoch, and W. Kisiel, Expression of protein C (PC), protein S (PS) and thrombomodulin (TM) in human colorectal cancer, Thromb Res, vol.125, issue.3, pp.71-75, 2010.

M. Volm, J. Mattern, and R. Koomagi, Angiostatin expression in non-small cell lung cancer, Clin Cancer Res, vol.6, issue.8, pp.3236-3240, 2000.

G. X. Ruan and A. Kazlauskas, Axl is essential for VEGF-A-dependent activation of PI3K/Akt, EMBO J, vol.31, issue.7, pp.1692-1703, 2012.

H. Uehara and E. Shacter, Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinasemediated phagocytosis of apoptotic cells, J Immunol, vol.180, issue.4, pp.2522-2530, 2008.

L. Kask, L. A. Trouw, B. Dahlback, and A. M. Blom, The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells, J Biol Chem, vol.279, issue.23, pp.23869-23873, 2004.

S. Sather, K. D. Kenyon, and J. B. Lefkowitz, A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation, Blood, vol.109, issue.3, pp.1026-1033, 2007.

K. J. Png, N. Halberg, M. Yoshida, and S. F. Tavazoie, A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells, Nature, vol.481, issue.7380, pp.190-194, 2011.

A. Angelillo-scherrer, P. De-frutos, and C. Aparicio, Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis, Nat Med, vol.7, issue.2, pp.215-221, 2001.

K. Nagata, K. Ohashi, and T. Nakano, Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases, J Biol Chem, vol.271, issue.47, pp.30022-30027, 1996.

S. Hafizi and B. Dahlback, Gas6 and protein S: vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily, FEBS J, vol.273, issue.23, pp.5231-5244, 2006.

I. Balogh, S. Hafizi, J. Stenhoff, K. Hansson, and B. Dahlback, Analysis of Gas6 in human platelets and plasma, Arterioscler Thromb Vasc Biol, vol.25, issue.6, pp.1280-1286, 2005.

C. Horbinski, C. Mojesky, and N. Kyprianou, Live free or die: tales of homeless (cells) in cancer, Am J Pathol, vol.177, issue.3, pp.1044-1052, 2010.