V. Budagian, E. Bulanova, R. Paus, and S. Bulfone-paus, IL-15/IL-15 receptor biology: a guided tour through an expanding universe, Cytokine Growth Factor Rev, vol.17, pp.259-280, 2006.

T. A. Waldmann, The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design, Nat Rev Immunol, vol.6, pp.595-601, 2006.

D. M. Anderson, S. Kumaki, M. Ahdieh, J. Bertles, and M. Tometsko, Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes, J Biol Chem, vol.270, pp.29862-29869, 1995.

J. G. Giri, M. Ahdieh, J. Eisenman, K. Shanebeck, and K. Grabstein, Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15, EMBO J, vol.13, pp.2822-2830, 1994.

J. Atzpodien, E. Lopez-hanninen, H. Kirchner, H. Bodenstein, and M. Pfreundschuh, Multiinstitutional home-therapy trial of recombinant human interleukin-2 and interferon alfa-2 in progressive metastatic renal cell carcinoma, J Clin Oncol, vol.13, pp.497-501, 1995.

D. De-totero, R. Meazza, M. Capaia, M. Fabbi, and B. Azzarone, The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways, Blood, vol.111, pp.517-524, 2008.

K. Ghoreschi, A. Laurence, O. Shea, and J. J. , Janus kinases in immune cell signaling, Immunol Rev, vol.228, pp.273-287, 2009.

Y. Rochman, R. Spolski, and W. J. Leonard, New insights into the regulation of T cells by gamma(c) family cytokines, Nat Rev Immunol, vol.9, pp.480-490, 2009.

S. Amorosi, I. Russo, G. Amodio, C. Garbi, and L. Vitiello, The cellular amount of the common gamma-chain influences spontaneous or induced cell proliferation, Journal of immunology, vol.182, pp.3304-3309, 2009.

P. E. Kovanen and W. J. Leonard, Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways, Immunol Rev, vol.202, pp.67-83, 2004.

N. B. Woods, V. Bottero, M. Schmidt, C. Von-kalle, and I. M. Verma, Gene therapy: therapeutic gene causing lymphoma, Nature, vol.440, p.1123, 2006.

I. Garcia-tunon, M. Ricote, A. Ruiz, B. Fraile, and R. Paniagua, Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study, Breast Cancer Res, vol.6, pp.1-7, 2004.

H. Kuniyasu, H. Ohmori, T. Sasaki, T. Sasahira, and K. Yoshida, Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis, Clin Cancer Res, vol.9, pp.4802-4810, 2003.

T. E. Reichert, S. Nagashima, Y. Kashii, J. Stanson, and G. Gao, Interleukin-2 expression in human carcinoma cell lines and its role in cell cycle progression, Oncogene, vol.19, pp.514-525, 2000.

N. Tejman-yarden, M. Zlotnik, E. Lewis, O. Etzion, and C. Chaimovitz, Renal cells express a functional interleukin-15 receptor, Nephrol Dial Transplant, vol.20, pp.516-523, 2005.

A. Tsukadaira, Y. Okubo, S. Koyama, E. Sato, and H. Nagase, Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor, Exp Lung Res, vol.28, pp.123-139, 2002.

D. Sabatino, A. Ciccocioppo, R. Cupelli, F. Cinque, B. Millimaggi et al., Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease, Gut, vol.55, pp.469-477, 2006.

N. Ge, Y. Nishioka, Y. Nakamura, Y. Okano, and K. Yoneda, Synthesis and secretion of interleukin-15 by freshly isolated human bronchial epithelial cells, Int Arch Allergy Immunol, vol.135, pp.235-242, 2004.

F. Obermeier, M. Hausmann, S. Kellermeier, S. Kiessling, and U. G. Strauch, IL-15 protects intestinal epithelial cells, Eur J Immunol, vol.36, pp.2691-2699, 2006.

M. Shinozaki, J. Hirahashi, T. Lebedeva, F. Y. Liew, and D. J. Salant, IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis, J Clin Invest, vol.109, pp.951-960, 2002.

M. Weiler, B. Rogashev, T. Einbinder, M. J. Hausmann, and J. Kaneti, Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells, J Am Soc Nephrol, vol.9, pp.1194-1201, 1998.

H. Eini, N. Tejman-yarden, E. C. Lewis, C. Chaimovitz, and M. Zlotnik, Association between renal injury and reduced interleukin-15 and interleukin-15 receptor levels in acute kidney injury, J Interferon Cytokine Res, vol.30, pp.1-8, 2009.

R. Nishiyama, T. Sakaguchi, T. Kinugasa, X. Gu, and R. P. Macdermott, Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions, J Biol Chem, vol.276, pp.35571-35580, 2001.

L. Maiuri, C. Ciacci, S. Auricchio, V. Brown, and S. Quaratino, Interleukin 15 mediates epithelial changes in celiac disease, Gastroenterology, vol.119, pp.996-1006, 2000.

H. C. Reinecker, R. P. Macdermott, S. Mirau, A. Dignass, and D. K. Podolsky, Intestinal epithelial cells both express and respond to interleukin 15, Gastroenterology, vol.111, pp.1706-1713, 1996.

M. Yanagita, Y. Shimabukuro, T. Nozaki, N. Yoshimura, and J. Watanabe, IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells, Biochem Biophys Res Commun, vol.297, pp.329-334, 2002.

E. Viey, C. Laplace, and B. Escudier, Peripheral gammadelta T-lymphocytes as an innovative tool in immunotherapy for metastatic renal cell carcinoma, Expert Rev Anticancer Ther, vol.5, pp.973-986, 2005.

J. Giron-michel, M. Giuliani, M. Fogli, D. Brouty-boye, and S. Ferrini, Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors, Blood, vol.106, pp.2302-2310, 2005.

K. Khawam, J. Giron-michel, Y. Gu, A. Perier, and M. Giuliani, Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-tomesenchymal transition, Cancer Res, vol.69, pp.1561-1569, 2009.

E. Mortier, J. Bernard, A. Plet, and Y. Jacques, Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist, J Immunol, vol.173, pp.1681-1688, 2004.

B. Bussolati, S. Bruno, C. Grange, U. Ferrando, and G. Camussi, Identification of a tumor-initiating stem cell population in human renal carcinomas, FASEB J, vol.22, pp.3696-3705, 2008.

J. Giron-michel, F. Menard, S. Negrini, A. Devocelle, and B. Azzarone, EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15, Blood, vol.113, pp.4541-4547, 2009.

S. R. Hofmann, A. Q. Lam, S. Frank, Y. J. Zhou, and H. L. Ramos, Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited, Mol Cell Biol, vol.24, pp.5039-5049, 2004.

J. R. Cortes, G. M. Perez, M. D. Rivas, and J. Zamorano, Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3, J Immunol, vol.179, pp.3881-3887, 2007.

T. Musso, J. A. Johnston, D. Linnekin, L. Varesio, and T. K. Rowe, Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7, J Exp Med, vol.181, pp.1425-1431, 1995.

K. P. Stone, A. J. Kastin, H. Hsuchou, C. Yu, and W. Pan, Rapid endocytosis of interleukin-15 by cerebral endothelia, J Neurochem, vol.116, pp.544-553, 2011.

F. Van-roy and G. Berx, The cell-cell adhesion molecule E-cadherin, Cell Mol Life Sci, vol.65, pp.3756-3788, 2008.

R. Sasson and A. Amsterdam, Pleiotropic anti-apoptotic activity of glucocorticoids in ovarian follicular cells, Biochem Pharmacol, vol.66, pp.1393-1401, 2003.

E. Sanchez-tillo, L. A. Torrent, R. Cuatrecasas, M. Vaquero, and E. C. , ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/ SNF chromatin-remodeling protein BRG1, Oncogene, vol.29, pp.3490-3500, 2010.

A. Wells, C. Yates, and C. R. Shepard, E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas, Clin Exp Metastasis, vol.25, pp.621-628, 2008.

G. Zheng, J. G. Lyons, T. K. Tan, Y. Wang, and T. T. Hsu, Disruption of Ecadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells, Am J Pathol, vol.175, pp.580-591, 2009.

S. Fiorito, L. Magrini, J. Adrey, D. Mailhe, and D. Brouty-boye, Inflammatory status and cartilage regenerative potential of synovial fibroblasts from patients with osteoarthritis and chondropathy, Rheumatology (Oxford), vol.44, pp.164-171, 2005.

M. Jakobisiak, J. Golab, and W. Lasek, Interleukin 15 as a promising candidate for tumor immunotherapy, Cytokine Growth Factor Rev, vol.22, pp.99-108, 2011.

W. K. Wong, H. Robertson, H. P. Carroll, S. Ali, and J. A. Kirby, Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells, Transplantation, vol.75, pp.505-514, 2003.

J. M. Yabu and F. Vincenti, Novel immunosuppression: small molecules and biologics, Semin Nephrol, vol.27, pp.479-486, 2007.

H. Ogbomo, M. Michaelis, B. Altenbrandt, H. W. Doerr, J. Cinatl et al., A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function, Biochem Pharmacol, vol.79, pp.188-197, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00535820

K. S. Lai, Y. Jin, D. K. Graham, B. A. Witthuhn, and J. N. Ihle, A kinasedeficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells, J Biol Chem, vol.270, pp.25028-25036, 1995.

L. Damiano, D. Stefano, P. , C. Leal, M. P. Barba et al., dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation, Oncogene, vol.29, pp.3677-3690, 2010.

M. Davies, M. Robinson, E. Smith, S. Huntley, and S. Prime, Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways, Journal of cellular biochemistry, vol.95, pp.918-931, 2005.

G. Gambaro and C. Abaterusso, Pathophysiology of hypercalciuria. American journal of physiology Renal physiology 293: F1758; author reply F1759, 2007.

S. Hamada, K. Satoh, M. Hirota, K. Kimura, and A. Kanno, Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line, Journal of cellular physiology, vol.213, pp.768-774, 2007.

G. Xu, A. Liu, and X. Liu, Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules, Nephrology, vol.13, pp.694-701, 2008.

G. Zhang, K. A. Kernan, S. J. Collins, X. Cai, and J. M. Lopez-guisa, Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-tomesenchymal transition: role of plasmin-activated signals, Journal of the American Society of Nephrology : JASN, vol.18, pp.846-859, 2007.

H. Peinado, F. Portillo, and A. Cano, Transcriptional regulation of cadherins during development and carcinogenesis, Int J Dev Biol, vol.48, pp.365-375, 2004.

L. D. Notarangelo, S. Giliani, P. Mella, R. F. Schumacher, and C. Mazza, Combined immunodeficiencies due to defects in signal transduction: defects of the gammac-JAK3 signaling pathway as a model, Immunobiology, vol.202, pp.106-119, 2000.

M. C. Bosco, I. Espinoza-delgado, M. Schwabe, G. L. Gusella, and D. L. Longo, Regulation by interleukin-2 (IL-2) and interferon gamma of IL-2 receptor gamma chain gene expression in human monocytes, Blood, vol.83, pp.2995-3002, 1994.

Y. Han, H. M. Amin, B. Franko, C. Frantz, and X. Shi, Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma, Blood, vol.108, pp.2796-2803, 2006.

K. Franciszkiewicz, L. Floc'h, A. Jalil, A. Vigant, F. Robert et al., Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention, Cancer Res, vol.69, pp.6249-6255, 2009.

L. Floc, &. , A. Jalil, A. Vergnon, I. et al., Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis, J Exp Med, vol.204, pp.559-570, 2007.