Human NK cell education by inhibitory receptors for MHC class I, Immunity, vol.25, pp.331-342, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00091535
Homozygous human TAP peptide transporter mutation in HLA class I de ciency, Science, vol.265, pp.237-241, 1994. ,
The impact of variation at the KIR gene cluster on human disease, Curr. Top. Microbiol. Immunol, vol.298, pp.225-257, 2006. ,
IL-15R ? chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation, J. Exp. Med, vol.205, pp.1213-1225, 2008. ,
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis, Annu. Rev. Immunol, vol.24, pp.657-679, 2006. ,
Converting IL-15 to a superagonist by binding to soluble IL-15R { alpha }, Proc. Natl. Acad. Sci. USA, vol.103, pp.9166-9171, 2006. ,
Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo, J. Immunol, vol.177, pp.6072-6080, 2006. ,
Molecular defects in human severe combined immunode ciency and approaches to immune reconstitution, Annu. Rev. Immunol, vol.22, pp.625-655, 2004. ,
Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-de cient form of severe combined immunode ciency, Blood, vol.98, pp.877-879, 2001. ,
Monitoring the e ect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2 ? / ? gammac ? / ? mice: functional inactivation of p53 in developing T cells, Blood, vol.104, pp.3886-3893, 2004. ,
Development of a human adaptive immune system in cord blood cell-transplanted mice, Science, vol.304, pp.104-107, 2004. ,
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells, J. Exp. Med, vol.201, pp.1421-1433, 2005. ,
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1, Nat. Immunol, vol.8, pp.856-863, 2007. ,
Interleukin 15: biology and relevance to human disease, Blood, vol.97, pp.14-32, 2001. ,
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins, J. Biol. Chem, vol.281, pp.1612-1619, 2006. ,
The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-a nity binding and is crucial for the IL-15 antagonistic e ect of soluble IL-15Ralpha, J. Mol. Biol, vol.382, pp.1-12, 2008. ,
A potential role for interleukin-15 in the regulation of human natural killer cell survival, J. Clin. Invest, vol.99, pp.937-943, 1997. ,
Bcl-xL is associated with the anti-apoptotic e ect of IL-15 on the survival of CD56(dim) natural killer cells, Mol. Immunol, vol.45, pp.2559-2569, 2008. ,
Acquisition of murine NK cell cytotoxicity 5 and 20 ng/ml, respectively. In vitro restimulation of HIS-derived NK cells was performed using CD56 + NK cells puri ed by magnetic beads (Miltenyi Biotech) from a cell suspension of spleen and bone marrow from seven HIS mice pooled together. NK cells were cultured at 2.5 × 10 5 cells/ml in RPMI supplemented with 10% FCS, p.15, 2007. ,
Systems) or 2.5 × 10 6 K562 cells/ml (American Type Culture Collection) for 18 h ,
Developmental pathways that generate natural-killer-cell diversity in mice and humans, Nat. Rev. Immunol, vol.7, pp.703-714, 2007. ,
CD16-CD56+ natural killer cells after bone marrow transplantation, Blood, vol.79, pp.3239-3244, 1992. ,
Two populations of CD56 (Leu-19)+/CD16+ cells in bone marrow transplant recipients, Bone Marrow Transplant, vol.5, pp.259-264, 1990. ,
CD56bright human NK cells di erentiate into CD56dim cells: role of contact with peripheral broblasts, J. Immunol, vol.179, pp.89-94, 2007. ,
CD56brightCD16-killer Ig-like receptor-NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation, J. Immunol, vol.178, pp.4947-4955, 2007. ,
, requires the translation of a pre-existing pool of granzyme B and perforin mRNAs, Immunity, vol.26, pp.798-811
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor, J. Exp. Med, vol.180, pp.1395-1403, 1994. ,
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature, Blood, vol.110, pp.578-586, 2007. ,
Membrane-bound and soluble IL-15/IL-15Ralpha complexes display di erential signaling and functions on human hematopoietic progenitors, Blood, vol.106, pp.2302-2310, 2005. ,
Genetic modi cation of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3, Blood, vol.94, pp.2637-2646, 1999. ,
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3, J. Exp. Med, vol.186, pp.1597-1602, 1997. ,
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus, Hum. Gene Ther, vol.7, pp.1405-1413, 1996. ,