Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-a production in rheumatoid arthritis, Nat Med, vol.3, pp.189-95, 1997. ,
Essential roles of DCderived IL-15 as a mediator of inflammatory responses in vivo, J Exp Med, vol.203, pp.2329-2367, 2006. ,
High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism, J Immunol, vol.164, pp.2832-2840, 2000. ,
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design, Nat Rev Immunol, vol.6, pp.595-601, 2006. ,
Interleukin-15 protects from lethal apoptosis in vivo, Nat Med, vol.3, pp.1124-1132, 1997. ,
IL-15 regulates CD8 + T cell contraction during primary infection, J Immunol, vol.176, pp.507-522, 2006. ,
IL-15Ra recycles and presents IL15 in trans to neighboring cells, Immunity, vol.17, pp.537-584, 2002. ,
Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented www.aacrjournals.org NK activity and cytotoxic T-cell response, Int J Cancer, vol.99, pp.573-581, 2002. ,
Role of transcellular IL-15 presentation in the activation of NK cellmediated killing, which leads to enhanced tumor immunosurveillance, Blood, vol.105, pp.721-728, 2005. ,
Interleukin-15 rescues tolerant CD8 + T cells for use in adoptive immunotherapy of established tumors, Nat Med, vol.12, pp.335-376, 2006. ,
IL-15 enhances the in vivo antitumor activity of tumorreactive CD8 + T cells, Proc Natl Acad Sci U S A, vol.101, pp.1969-74, 2004. ,
Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8 + T cells, J Exp Med, vol.193, pp.219-250, 2001. ,
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway, Proc Natl Acad Sci U S A, vol.98, pp.7970-7975, 2001. ,
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier, J Natl Cancer Inst, vol.99, pp.1257-69, 2007. ,
Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma, Cancer Sci, vol.98, pp.740-746, 2007. ,
Prognostic value of tumor-infiltrating CD4 + T-cell subpopulations in head and neck cancers, Clin Cancer Res, vol.12, pp.465-72, 2006. ,
Nuclear factor-nBrelated serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma, Clin Cancer Res, vol.13, pp.3182-90, 2007. ,
Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo, Clin Cancer Res, vol.13, pp.1601-1611, 2007. ,
Natural, proteolytic release of a soluble form of human IL-15 receptor a-chain that behaves as a specific, high affinity IL-15 antagonist, J Immunol, vol.173, pp.1681-1689, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437358
Natural soluble interleukin-15Ra is generated by cleavage that involves the tumor necrosis factor-a-converting enzyme (TACE/ADAM17), J Biol Chem, vol.279, pp.40368-75, 2004. ,
Soluble interleukin IL-15Ra is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15, J Biol Chem, vol.282, pp.13167-79, 2007. ,
Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo, J Immunol, vol.174, pp.5507-5522, 2005. ,
Selective blockade of IL-15 by soluble IL-15 receptor a-chain enhances cardiac allograft survival, J Immunol, vol.165, pp.344-450, 2000. ,
Soluble interleukin-15 receptor a (IL-15Ra)-sushi as a selective and potent agonist of IL-15 action through IL-15Rh/g. Hyperagonist IL-15 Â IL-15Ra fusion proteins, J Biol Chem, vol.281, pp.1612-1621, 2006. ,
Interleukin-17 inhibits tumor cell growth by means of a T-celldependent mechanism, Blood, vol.99, pp.2114-2135, 2002. ,
Serum soluble interleukin-2 receptor concentrations as an independent prognostic marker in head and neck cancer, Lancet, vol.357, pp.1263-1267, 2001. ,
Membrane-bound interleukin (IL)-15 on renal tumor cells rescues natural killer cells from IL-2 starvationinduced apoptosis, Cancer Res, vol.67, pp.5594-5603, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00158208
Differentiation of CD8 + T cells from tumor-invaded and tumor-free lymph nodes of melanoma patients: role of common g-chain cytokines, J Immunol, vol.171, pp.2134-2175, 2003. ,
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice, Cancer Res, vol.59, pp.3698-704, 1999. ,
Interleukin-17 promotes angiogenesis and tumor growth, Blood, vol.101, pp.2620-2627, 2003. ,
Combined IL-15/IL-15Ra immunotherapy maximizes IL-15 activity in vivo, J Immunol, vol.177, pp.6072-80, 2006. ,
Converting IL-15 to a superagonist by binding to soluble IL-15Ra, Proc Natl Acad Sci, vol.103, pp.9166-71, 2006. ,
Identification of an interleukin-15a receptor-binding site on human interleukin-15, J Biol Chem, vol.279, pp.24313-24335, 2004. ,
Membranebound and soluble IL-15/IL-15Ra complexes display differential signaling and functions on human hematopoietic progenitors, Blood, vol.106, pp.2302-2312, 2005. ,
TGF-h suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling, Immunity, vol.21, pp.491-501, 2004. ,
IL-15/IL-15Ra-mediated avidity maturation of memory CD8 + T cells, Proc Natl Acad Sci U S A, vol.101, pp.15154-15163, 2004. ,
Protective mechanisms of head and neck squamous cell carcinomas from immune assault, Head Neck, vol.28, pp.462-70, 2006. ,
Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma, Clin Cancer Res, vol.8, pp.3137-3182, 2002. ,
Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance, Clin Cancer Res, vol.8, pp.2553-62, 2002. ,
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment, Nat Rev Immunol, vol.7, pp.41-51, 2007. ,
A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma, Head Neck, vol.27, pp.771-84, 2005. ,
Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis, Clin Cancer Res, vol.9, pp.4802-4812, 2003. ,
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion, Cancer Res, vol.65, pp.9113-9119, 2005. ,
Paradoxical roles of the immune system during cancer development, Nat Rev Cancer, vol.6, pp.24-37, 2006. ,
Inflammation-associated cancer: NF-nB is the lynchpin, Trends Immunol, vol.26, pp.318-343, 2005. ,
, Cancer. Sex, cytokines, and cancer. Science, vol.317, pp.51-53, 2007.
A cytokine-mediated link between innate immunity, inflammation, and cancer, J Clin Invest, vol.117, pp.1175-83, 2007. ,
Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate, Prostate, vol.49, pp.251-62, 2001. ,
Targeting TACE-dependent EGFR ligand shedding in breast cancer, J Clin Invest, vol.117, pp.337-382, 2007. ,
Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer, Clin Cancer Res, vol.13, pp.1892-902, 2007. ,