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Pleiotropic functions of tumor suppressor WWOX in normal and cancer cells, J Biol Chem, vol.290, pp.30728-30763, 2015. ,
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies, Biochim Biophys Acta, vol.1846, pp.188-200, 2014. ,
The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation, Brain, vol.137, pp.411-420, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02434727
Alteration of WWOX in human cancer: a clinical view, Exp Biol Med (Maywood), vol.240, pp.305-319, 2015. ,
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer, Cancer Res, vol.60, pp.2140-2145, 2000. ,
Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors, Oncogene, vol.21, pp.1832-1872, 2002. ,
miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene, Int J Cancer, vol.134, pp.811-832, 2014. ,
MicroRNA-153 promotes Wnt/ beta-catenin activation in hepatocellular carcinoma through suppression of WWOX, Oncotarget, vol.6, pp.3840-3847, 2015. ,
WWOX, the FRA16D gene, behaves as a suppressor of tumor growth, Cancer Res, vol.61, pp.8068-73, 2001. ,
WWOX gene restoration prevents lung cancer growth in vitro and in vivo, Proc Natl Acad Sci, vol.102, pp.15611-15617, 2005. ,
Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression, Clin Cancer Res, vol.13, pp.268-74, 2007. ,
A role for the WWOX gene in prostate cancer, Cancer Res, vol.66, pp.6477-81, 2006. ,
Targeted deletion of Wwox reveals a tumor suppressor function, Proc Natl Acad Sci, vol.104, pp.3949-54, 2007. ,
Wwox inactivation enhances mammary tumorigenesis, Oncogene, vol.30, pp.3900-3906, 2011. ,
WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy, Genes Chromosomes Cancer, vol.46, pp.1129-1165, 2007. ,
Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo, Cancer Res, vol.67, pp.5606-5616, 2007. ,
Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells, Hum Mol Genet, vol.9, pp.1651-63, 2000. ,
WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins, Oncogene, vol.23, pp.5049-55, 2004. ,
Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks, J Biol Chem, vol.289, pp.8865-80, 2014. ,
WWOX gene and gene product: tumor suppression through specific protein interactions, Future Oncol, vol.6, pp.249-59, 2010. ,
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein, Oncogene, vol.28, pp.2569-80, 2009. ,
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog, Proc Natl Acad Sci U S A, vol.101, pp.4401-4407, 2004. ,
WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response, Proc Natl Acad Sci, vol.111, pp.4716-4741, 2014. ,
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A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma, Neuro-Oncology, vol.4, pp.86-94, 2002. ,
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Epidermal growth factor receptor-coamplified and overexpressed protein (VOPP1) is a putative oncogene in gastric cancer, Clin Exp Med, vol.15, pp.469-75, 2014. ,
Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification, Oncogene, vol.28, pp.2919-2943, 2009. ,
Intracellular localization of GASP/ECOP/VOPP1, J Mol Histol, vol.41, pp.153-64, 2010. ,
Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury, Lab Investig, vol.9, pp.1170-80, 2011. ,
ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner, Oncogene, vol.24, pp.2495-502, 2005. ,
The tumor-suppressor WWOX and HDAC3 inhibit the transcriptional activity of the beta-catenin coactivator BCL9-2 in breast cancer cells, Mol Cancer Res, vol.13, pp.902-914, 2015. ,
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Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer, J Natl Cancer Inst, vol.101, pp.736-50, 2009. ,
Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients, Oncol Rep, vol.29, pp.1467-74, 2013. ,
Association of Wwox with ErbB4 in breast cancer, Cancer Res, vol.67, pp.9330-9336, 2007. ,
The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype, J Cancer Res Clin Oncol, vol.137, pp.271-279, 2011. ,
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SIMPLE/ LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments, PLoS One, vol.6, p.16873, 2011. ,
Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats, PLoS One, vol.4, p.7820, 2009. ,
The tumor suppressor gene WWOX links the canonical and noncanonical NF-kappaB pathways in HTLV-I Tax-mediated tumorigenesis, Blood, vol.117, pp.1652-61, 2011. ,
Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species, Hum Mol Genet, vol.20, pp.497-509, 2011. ,
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism, Exp Biol Med (Maywood), vol.240, pp.345-50, 2015. ,
WWOX inhibits the invasion of lung cancer cells by downregulating RUNX2, Cancer Gene Ther, vol.23, pp.433-441, 2016. ,
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration, PLoS One, vol.7, p.37823, 2012. ,
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Two new p73 splice variants, gamma and delta, with different transcriptional activity, J Exp Med, vol.188, pp.1763-1771, 1998. ,
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AIP4 restricts transforming growth factor-beta signaling through a ubiquitinationindependent mechanism, J Biol Chem, vol.280, pp.27645-53, 2005. ,
Identification of CGA as a novel estrogen receptor-responsive gene in breast cancer: an outstanding candidate marker to predict the response to endocrine therapy, Cancer Res, vol.61, pp.1652-1660, 2001. ,
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