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Journal articles
Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV)
Ana Lopes
1, 2, 3
Lorenzo Capucci
4
Dolores Gavier-Widén
5, 6
Ghislaine Le Gall-Reculé
7, 8
Emiliana Brocchi
4
Ilaria Barbieri
4
Agnès Quéméner
2
Jacques Le Pendu
2
Jemma Geoghegan
9
Edward Holmes
9
Pedro Esteves
10, 1, 11
Joana Abrantes
12
Ana M. Lopes 1, 2, 3
Author
Lorenzo Capucci 4
Author
Dolores Gavier-Widén 5, 6
Author
Ghislaine Le Gall-Reculé 7, 8
Author
Emiliana Brocchi 4
Author
Ilaria Barbieri 4
Author
Agnès Quéméner 2
Author IdHAL : quemener-a ResearcherId : http://www.researcherid.com/rid/K-9562-2015 ORCID : https://orcid.org/0000-0002-4026-8496
Jacques Le Pendu 2
Author
Jemma L Geoghegan 9
Author
Edward C Holmes 9
Author
Pedro Esteves 10, 1, 11
Author
Joana Abrantes 12
Author
1
Departamento de Biologia [Porto, Portugal] (Rua do Campo Alegre 1021/1055, 4169-007 Porto - Portugal)
- FCUP - Faculdade de Ciências da Universidade do Porto (Rua do Campo Alegre, 4169-007 Porto - Portugal)
- Universidade do Porto (Praça de Gomes Teixeira, 4099-002 Porto - Portugal)
2
CRCNA - Centre de Recherche en Cancérologie Nantes-Angers (France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel-Dieu de Nantes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U892 (101, rue de Tolbiac, 75013 Paris - France)
- Hôpital Laennec (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6299 (France)
- Faculté de Médecine d'Angers (Rue Haute de Reculée 49045 Angers - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
3
CIBIO/UP-Centro de Investigação em Biodiversidade e Recursos Genéticos [Vairão, Portugal] (Campus Agrário de Vairão, Rua Padre Armando Quintas;4485-661;Vairão - Portugal)
- Universidade do Porto (Praça de Gomes Teixeira, 4099-002 Porto - Portugal)
4
IZSLER - Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" (Via Bianchi, 9 - 25124 Brescia - Italy)
6
Department of Biomedical Sciences and Veterinary Public Health - Section of Immunology [Uppsala, Sweden] (Sweden)
- SLU - Swedish University of Agricultural Sciences (S-750 07 Uppsala - Sweden)
- Veterinary and Animal Science Center [Uppsala, Sweden] (Sweden)
7
ANSES - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (14 rue Pierre et Marie Curie
94701 MAISONS-ALFORT Cedex - France)
8
UEB - Université européenne de Bretagne - European University of Brittany (5 boulevard Laënnec - 35000 Rennes - France)
9
SEIB - Sydney Emerging Infectious Diseases and Biosecurity Institute (Sydney - Australia)
- The University of Sydney (New South Wales 2006 - Australia)
10
CIBIO-UP (Centro de Investigacao em Biodiversidade e Recursos Geneticos - Campus Agrario de Vairao, Rua Padre Armando Quintas, nr.7, 4485-661 Vairao - Portugal)
- Universidade do Porto (Praça de Gomes Teixeira, 4099-002 Porto - Portugal)
12
CIBIO-UP - Centro de Investigacao em Biodiverdidade e Recursos Geneticos (Campus Agra´rio de Vairao, Rua Monte-Crasto, Pt-4485-661 Vairao - Portugal)
- Universidade do Porto (Praça de Gomes Teixeira, 4099-002 Porto - Portugal)
Abstract : European brown hare syndrome virus(EBHSV) is the aetiological agent of European brown hare syndrome (EBHS), a disease affecting Lepus europaeus and Lepus timidus first diagnosed in Sweden in 1980. To characterize EBHSV evolution we studied hare samples collected in Sweden between 1982 and2008. Our molecular clock dating is compatible with EBHSV emergence in the 1970s. Phylogenetic analysis revealed two lineages: Group A persisted until 1989 when it apparently suffered extinction; Group B emerged in the mid-1980s and contains the most recent strains. Antigenic differences exist between groups, with loss of reactivity of some MAbs overtime, which are associated with aminoacid substitutions in recognized epitopes. A role for immune selection is also supported by the presence of positively selected codons in exposed regions of the capsid. Hence, EBHSV evolution is characterized by replacement of Group A by Group B viruses, suggesting that the latter possess a selective advantage.
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https://www.hal.inserm.fr/inserm-02441033
Contributor : Agnès Quemener Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 3:32:17 PM
Last modification on : Friday, October 8, 2021 - 4:06:06 PM
Long-term archiving on: : Thursday, April 16, 2020 - 4:03:07 PM
Contributor : Agnès Quemener Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 3:32:17 PM
Last modification on : Friday, October 8, 2021 - 4:06:06 PM
Long-term archiving on: : Thursday, April 16, 2020 - 4:03:07 PM
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Identifiers
- HAL Id : inserm-02441033, version 1
- DOI : 10.1016/j.virol.2014.08.002
- PUBMED : 25155199
Citation
Ana Lopes, Lorenzo Capucci, Dolores Gavier-Widén, Ghislaine Le Gall-Reculé, Emiliana Brocchi, et al.. Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV). Virology, Elsevier, 2014, 468-470, pp.104-112. ⟨10.1016/j.virol.2014.08.002⟩. ⟨inserm-02441033⟩
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