2PremUp Foundation (Fondation de Coopération Scientifique sur la Grossesse et la Prématurité - Maternité de Port Royal - 53 avenue de l'Observatoire - 75014 Paris - France)
Abstract : The peroxisome-proliferator-activated-receptor-(PPAR) is a member of the nuclear receptor superfamily that plays a critical role in diverse biological processes, including adipogenesis, lipid metabolism, and placental development. To study the activity of PPAR , we constructed two new reporter genes: a fluorescent GFP-tagged histone-2B (PPRE-H2B-eGFP) and a secreted nanoluciferase (PPRE-pNL1.3[secNluc]). This study demonstrates their usage to monitor PPAR activity in different cell types and screen for PPAR 's potential ligands.
https://www.hal.inserm.fr/inserm-02440451 Contributor : Séverine DEGRELLEConnect in order to contact the contributor Submitted on : Wednesday, January 15, 2020 - 10:57:15 AM Last modification on : Sunday, June 26, 2022 - 12:13:32 PM Long-term archiving on: : Thursday, April 16, 2020 - 2:05:08 PM