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Journal articles
New Transcriptional Reporters to Quantify and Monitor PPAR γ Activity
Abstract : The peroxisome-proliferator-activated-receptor-(PPAR) is a member of the nuclear receptor superfamily that plays a critical role in diverse biological processes, including adipogenesis, lipid metabolism, and placental development. To study the activity of PPAR , we constructed two new reporter genes: a fluorescent GFP-tagged histone-2B (PPRE-H2B-eGFP) and a secreted nanoluciferase (PPRE-pNL1.3[secNluc]). This study demonstrates their usage to monitor PPAR activity in different cell types and screen for PPAR 's potential ligands.
Cited literature [27 references]
https://www.hal.inserm.fr/inserm-02440451
Contributor : Séverine Degrelle Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 10:57:15 AM
Last modification on : Saturday, December 4, 2021 - 4:00:26 AM
Long-term archiving on: : Thursday, April 16, 2020 - 2:05:08 PM
Contributor : Séverine Degrelle Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 10:57:15 AM
Last modification on : Saturday, December 4, 2021 - 4:00:26 AM
Long-term archiving on: : Thursday, April 16, 2020 - 2:05:08 PM
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E6_Degrelle_PPARResearch_2017....
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