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Journal articles
Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole
Abstract : To invade cells, the parasite Toxoplasma gondii injects a multi-unit nanodevice into the target cell plasma membrane (PM). The core nanodevice, which is composed of the RhOptry Neck (RON) protein complex, connects Toxoplasma and host cell through a circular tight junction (TJ). We now report that this RON nanodevice mechanically promotes membrane scission at the TJ-PM interface, directing a physical rotation driven by the parasite twisting motion that enables the budding parasitophorous vacuole (PV) to seal and separate from the host cell PM as a bona fide subcellular Toxoplasma-loaded PV. Mechanically impairing the process induces swelling of the budding PV and death of the parasite but not host cell. Moreover, this study reveals that the parasite nanodevice functions as a molecular trigger to promote PV membrane remodeling and rapid onset of T. gondii to intracellular lifestyle.
Cited literature [36 references]
https://www.hal.inserm.fr/inserm-02440390
Contributor : Mohamed-ali HAKIMI Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 10:40:54 AM
Last modification on : Thursday, April 7, 2022 - 10:10:38 AM
Long-term archiving on: : Thursday, April 16, 2020 - 1:46:34 PM
Contributor : Mohamed-ali HAKIMI Connect in order to contact the contributor
Submitted on : Wednesday, January 15, 2020 - 10:40:54 AM
Last modification on : Thursday, April 7, 2022 - 10:10:38 AM
Long-term archiving on: : Thursday, April 16, 2020 - 1:46:34 PM