Burden of disease from cryptosporidiosis, Curr. Opin. Infect. Dis, vol.25, pp.555-563, 2012. ,
Global, regional, and national causes of under-5 mortality in 2000-15: An updated systematic analysis with implications for the Sustainable Development Goals, Lancet, vol.388, pp.3027-3035, 2016. ,
, Burden and aetiology of diarrhoeal disease in infants and young, vol.382, pp.209-222, 2013.
,
, Lancet Glob. Health, vol.3, pp.564-575, 2015.
, WHO report, WHO | World health report Report, 2017.
Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: A randomised controlled trial, Lancet, vol.360, pp.1375-1380, 2002. ,
High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: A randomised controlled trial, BMC Infect. Dis, vol.9, p.195, 2009. ,
, A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium, vol.15, pp.85-94, 2015.
The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments, Bioorg. Med. Chem, vol.22, pp.4462-4473, 2014. ,
, Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis, vol.9, pp.385-394, 2017.
, A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue, vol.8, p.14574, 2017.
Polyadenylation factor CPSF-73 is the pre-mRNA 3?-end-processing endonuclease, Nature, vol.444, pp.953-956, 2006. ,
Evidence that polyadenylation factor CPSF-73 is the mRNA 3? processing endonuclease, RNA, vol.10, pp.565-573, 2004. ,
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing, PLOS Pathog, vol.14, p.1007315, 2018. ,
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3, Proc. Natl. Acad. Sci. U.S.A, vol.115, pp.9616-9621, 2018. ,
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis, Nature, vol.546, pp.376-380, 2017. ,
, Nature, vol.504, pp.248-253, 2013.
Van Voorhis, Necessity of bumped kinase inhibitor gastrointestinal exposure in treating Cryptosporidium infection, J. Infect. Dis, vol.216, pp.55-63, 2017. ,
B1-Metallo-b-Lactamases: Where do we stand?, Curr. Drug Targets, vol.17, pp.1029-1050, 2016. ,
Selection of carbonic anhydrase variants displayed on phage. Aromatic residues in zinc binding site enhance metal affinity and equilibration kinetics, J. Biol. Chem, vol.272, pp.20364-20372, 1997. ,
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis, PLOS Negl. Trop. Dis, vol.5, p.1151, 2011. ,
Benzoxaboroles: A new class of potential drugs for human African trypanosomiasis, Future Med. Chem, vol.3, pp.1259-1278, 2011. ,
Architecture of eukaryotic mRNA 3?-end processing machinery, Science, vol.358, pp.1056-1059, 2017. ,
Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex, vol.6, p.33111, 2017. ,
Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex, Nat. Struct. Mol. Biol, vol.25, pp.135-138, 2018. ,
Molecular basis for the recognition of the human AAUAAA polyadenylation signal, Proc. Natl. Acad. Sci. U.S.A, vol.115, pp.1419-1428, 2018. ,
Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase, Antimicrob. Agents Chemother, vol.60, pp.5817-5827, 2016. ,
A proposed target product profile and developmental cascade for new cryptosporidiosis treatments, PLOS Negl. Trop. Dis, vol.9, p.3987, 2015. ,
Cryptosporidiosis drug discovery: Opportunities and challenges, ACS Infect. Dis, vol.2, pp.530-537, 2016. ,
Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum, Nature, vol.523, pp.477-480, 2015. ,
A stem-cell-derived platform enables complete Cryptosporidium development in vitro and genetic tractability, Cell Host Microbe, vol.26, pp.123-134, 2019. ,
Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection, Infect. Immun, vol.70, pp.2090-2099, 2002. ,
Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice, J. Infect. Dis, vol.193, pp.1400-1407, 2006. ,
Cryptosporidium parvum-specific mucosal immune response in C57BL/6 neonatal and gamma interferon-deficient mice: Role of tumor necrosis factor alpha in protection, Infect. Immun, vol.69, pp.1635-1642, 2001. ,
Expression, crystallization and X-ray data collection from microcrystals of the extracellular domain of the human inhibitory receptor expressed on myeloid cells IREM-1, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun, vol.63, pp.204-208, 2007. ,
Automated harvesting and processing of protein crystals through laser photoablation, Acta Crystallogr. D Struct. Biol, vol.72, pp.454-466, 2016. ,
Coot: Model-building tools for molecular graphics, Acta Crystallogr. D Biol. Crystallogr, vol.60, pp.2126-2132, 2004. ,
Refinement of macromolecular structures by the maximum-likelihood method, Acta Crystallogr. D Biol. Crystallogr, vol.53, pp.240-255, 1997. ,
The SWISS-MODEL workspace: A web-based environment for protein structure homology modelling, Bioinformatics, vol.22, pp.195-201, 2006. ,
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