, PLBIO10-195 and INCA-6530) and International Re-integration Grant Marie Curie. Author contributions SC and NF designed and performed experiments, analysed data and wrote the manuscript
Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines, Methods, vol.19, pp.103-107, 1999. ,
Dendritic cells and the control of immunity, Nature, vol.392, pp.245-252, 1998. ,
Genetic analysis of host resistance: toll-like receptor signaling and immunity at large, Annu Rev Immunol, vol.24, pp.353-389, 2006. ,
Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes, Vaccine, vol.29, pp.1812-1823, 2011. ,
Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4 + T cell activation, Immunity, vol.27, pp.625-634, 2007. ,
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6, Immunity, vol.34, pp.932-946, 2011. ,
Follicular helper CD4 + T cells (T(FH)), Annu Rev Immunol, vol.29, pp.621-663, 2011. ,
Compartment-specific control of signaling from a DNA-sensing immune receptor, Sci Signal, vol.3, p.45, 2010. ,
Lymphoid reservoirs of antigen-specific memory T helper cells, Nat Immunol, vol.8, pp.753-761, 2007. ,
Follicular helper T cells: lineage and location, Immunity, vol.30, pp.324-335, 2009. ,
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding, Nat Immunol, vol.10, pp.375-384, 2009. ,
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen, Cell, vol.87, pp.1037-1047, 1996. ,
Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion, Proc Natl Acad Sci, vol.104, pp.4553-4558, 2007. ,
, , 2006.
, Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling, Science, vol.314, pp.1936-1938
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting, Cell, vol.73, pp.1155-1164, 1993. ,
From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets, Eur J Immunol, vol.40, pp.2089-2094, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00583366
Dendritic cell subsets in primary and secondary T cell responses at body surfaces, Nat Immunol, vol.10, pp.1237-1244, 2009. ,
Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19, J Leukoc Biol, vol.80, pp.1328-1336, 2006. ,
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction, Nature, vol.434, pp.1035-1040, 2005. ,
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response, Immunity, vol.34, pp.375-384, 2011. ,
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity, Immunity, vol.19, pp.47-57, 2003. ,
Innate immune recognition, Annu Rev Immunol, vol.20, pp.197-216, 2002. ,
TLR9 signaling in B cells determines class switch recombination to IgG2a, J Immunol, vol.178, pp.2415-2420, 2007. ,
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation, Science, vol.325, pp.1006-1010, 2009. ,
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8 + T cells by exogenous cell-associated antigens, Immunity, vol.17, pp.211-220, 2002. ,
Immunotherapeutic uses of CpG oligodeoxynucleotides, Nat Rev Immunol, vol.4, pp.249-258, 2004. ,
CpG motifs in bacterial DNA and their immune effects, Annu Rev Immunol, vol.20, pp.709-760, 2002. ,
CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization, J Immunol, vol.188, pp.1751-1760, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00685822
Bcl6 expression specifies the T follicular helper cell program in vivo, J Exp Med, vol.209, pp.1841-1852, 2012. ,
Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties, Immunity, vol.21, pp.669-679, 2004. ,
Vaccine adjuvants alter TCR-based selection thresholds, Immunity, vol.28, pp.698-709, 2008. ,
Environmental and T cell-intrinsic factors limit the expansion of neonatal, 2012. ,
, Follicular T Helper cells but may be circumvented by specific adjuvants, J Immunol, vol.189, pp.5764-5772
Antigen-specific memory B cell development, Annu Rev Immunol, vol.23, pp.487-513, 2004. ,
Human blood CXCR5(+)CD4(+) T cells are counterparts of T Follicular Cells and contain, EMBO Molecular Medicine, vol.6, issue.5, pp.108-121, 2011. ,
A novel MHC class II epitope expressed in thymic medulla but not cortex, Nature, vol.338, pp.765-768, 1989. ,
Monoclonal antibody detection of a major self peptide MHC class II complex, J Immunol, vol.148, pp.3483-3491, 1992. ,
Mechanisms of adjuvancy: I-Metal oxides as adjuvants, Vaccine, vol.15, pp.1183-1193, 1997. ,
Bcl6 mediates the development of T follicular helper cells, Science, vol.325, pp.1001-1005, 2009. ,
Control of B-cell responses by toll-like receptors, Nature, vol.438, pp.364-368, 2005. ,
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T Helper 2 cell-mediated immunity to house dust mite allergen, Immunity, vol.38, pp.322-335, 2013. ,
Immunological mechanisms of vaccination, Nat Immunol, vol.131, pp.509-517, 2011. ,
SAP-controlled T-B cell interactions underlie germinal centre formation, Nature, vol.455, pp.764-769, 2008. ,
Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes, J Exp Med, vol.200, pp.1231-1241, 2004. ,
Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo, Immunity, vol.11, pp.753-761, 1999. ,
On the complexity of self, Nature, vol.353, pp.660-662, 1991. ,
Human inflammatory dendritic cells induce th17 cell differentiation, Immunity, vol.38, pp.336-348, 2013. ,
The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells, J Immunol, vol.180, pp.5402-5412, 2008. ,
Development and characterization of IL-21-producing CD4 + T cells, J Exp Med, vol.205, pp.1369-1379, 2008. ,
A fundamental role for interleukin-21 in the generation of T follicular helper cells, Immunity, vol.29, pp.127-137, 2008. ,
Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice, Vaccine, vol.26, pp.552-561, 2008. ,
T follicular helper cells survive as long-term memory cells, Eur J Immunol, vol.42, pp.1981-1988, 2012. ,
, The transcriptional repressor Bcl, issue.6, 2009.
, T follicular helper cell lineage commitment. Immunity, vol.31, pp.457-468