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Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140

Abstract : Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.
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https://www.hal.inserm.fr/inserm-02439773
Contributor : Marion Lapierre <>
Submitted on : Tuesday, January 14, 2020 - 5:39:29 PM
Last modification on : Wednesday, January 15, 2020 - 1:34:21 AM
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Vincent Cavaillès, Marion Lapierre. Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140. Molecular & Cellular Oncology, Taylor et Francis, 2014, 1 (2), pp.e960761. ⟨10.4161/23723548.2014.960761⟩. ⟨inserm-02439773⟩

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