A. Abedini and D. P. Raleigh, A role for helical intermediates in amyloid formation by natively unfolded polypeptides?, Phys Biol, vol.6, p.15005, 2009.

R. Akter, P. Cao, H. Noor, Z. Ridgway, L. H. Tu et al., Islet amyloid polypeptide: structure, function, and pathophysiology, J Diabetes Res, p.2798269, 2016.

T. M. Allen and L. G. Cleland, Serum-induced leakage of liposome contents, Biochim Biophys Acta, vol.597, pp.418-426, 1980.

T. Bartels, L. S. Ahlstrom, A. Leftin, F. Kamp, C. Haass et al., The N-terminus of the intrinsically disordered protein alpha-synuclein triggers membrane binding and helix folding, Biophys J, vol.99, pp.2116-2124, 2010.

T. Bartels, J. G. Choi, and D. J. Selkoe, alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation, Nature, vol.477, pp.107-110, 2011.

C. R. Bodner, C. M. Dobson, and A. Bax, Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy, J Mol Biol, vol.390, pp.775-790, 2009.

J. M. Boettcher, K. L. Hartman, D. T. Ladror, Z. Qi, W. S. Woods et al., Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha, Biochemistry, vol.47, pp.12357-12364, 2008.

J. Burre, M. Sharma, T. Tsetsenis, V. Buchman, M. R. Etherton et al., ) alpha-Synuclein promotes SNARE-complex assembly in vivo and in vitro, Science, vol.329, pp.1663-1667, 2010.

. Bussell-r-jr and D. Eliezer, A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins, J Mol Biol, vol.329, pp.763-778, 2003.

R. H. Chen, S. Wislet-gendebien, F. Samuel, N. P. Visanji, G. Zhang et al., alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity, J Biol Chem, vol.288, pp.7438-7449, 2013.

G. Comellas, L. R. Lemkau, D. H. Zhou, J. M. George, and C. M. Rienstra, Structural intermediates during alpha-synuclein fibrillogenesis on phospholipid vesicles, J Am Chem Soc, vol.134, pp.5090-5099, 2012.

K. A. Conway, S. Lee, J. Rochet, T. T. Ding, R. E. Williamson et al., Acceleration of oligomerization, not fibrillization, is a shared property of both ?-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy, Proc Natl Acad Sci U S A, vol.97, pp.571-576, 2000.

W. S. Davidson, J. A. Clayton, D. F. George, and J. M. , Stabilization of ?-synuclein secondary structure upon binding to synthetic membranes, J Biol Chem, vol.273, pp.9443-9449, 1998.

D. A. Delgado, K. Doherty, Q. Cheng, H. Kim, D. Xu et al., Distinct membrane disruption pathways are induced by 40-Residue beta-amyloid peptides, J Biol Chem, vol.291, pp.12233-12244, 2016.

D. Dexter, C. Carter, F. Agid, Y. Agid, A. J. Lees et al., Lipid peroxidation as cause of nigral cell death in Parkinson's disease, Lancet, vol.2, pp.639-640, 1986.

J. Diao, J. Burre, S. Vivona, D. J. Cipriano, M. Sharma et al., Native ?-synuclein induced clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2, vol.2, p.592, 2013.

J. Dou, C. Cui, F. Dufour, D. L. Alkon, and W. Q. Zhao, Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress, J Neurochem, vol.87, pp.1086-1100, 2003.

I. Dulubova, A. Horiuchi, G. L. Snyder, J. A. Girault, A. J. Czernik et al., ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins, J Neurochem, vol.77, pp.229-238, 2001.

M. F. Engel, L. Khemtemourian, C. C. Kleijer, H. J. Meeldijk, J. Jacobs et al., Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane, Proc Natl Acad Sci U S A, vol.105, pp.6033-6038, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02344616

C. Galvagnion, A. K. Buell, G. Meisl, T. C. Michaels, M. Vendruscolo et al., Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation, Nat Chem Biol, vol.11, pp.229-234, 2015.

E. Gomez-tortosa, K. Newell, M. C. Irizarry, M. Albert, J. H. Growdon et al., Clinical and quantitative pathologic correlates of dementia with Lewy bodies, Neurology, vol.53, pp.1284-1291, 1999.

F. Haque, A. P. Pandey, L. R. Cambrea, J. C. Rochet, and J. S. Hovis, Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies, J Phys Chem B, vol.114, pp.4070-4081, 2010.

J. A. Hebda, I. Saraogi, M. Magzoub, A. D. Hamilton, and A. D. Miranker, A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes, Chem Biol, vol.16, pp.943-950, 2009.

L. Heron, A. Virsolvy, K. Peyrollier, F. M. Gribble, L. Cam et al., Human alpha-endosulfine, a possible regulator of sulfonylureasensitive KATP channel: molecular cloning, expression and biological properties, Proc Natl Acad Sci U S A, vol.95, pp.8387-8391, 1998.

C. C. Jao, A. Der-sarkissian, J. Chen, and R. Langen, Structure of membranebound alpha-synuclein studied by site-directed spin labeling, Proc Natl Acad Sci U S A, vol.101, pp.8331-8336, 2004.

J. M. Jenco, A. Rawlingson, B. Daniels, and A. J. Morris, Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by ?-and ?-synucleins, Biochemistry, vol.37, pp.4901-4909, 1998.

J. E. Darabie, A. A. Han, K. Tandon, A. Fraser, P. E. Mclaurin et al., alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis, Eur J Biochem, vol.271, pp.3180-3189, 2004.

J. E. Mclaurin, J. Yip, C. M. St, P. George-hyslop, and P. E. Fraser, ) ?-Synuclein membrane interactions and lipid specificity, J Biol Chem, vol.275, pp.34328-34334, 2000.

A. P. Kiely, Y. T. Asi, E. Kara, P. Limousin, H. Ling et al., ) alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?, Acta Neuropathol, vol.125, pp.753-769, 2013.

S. H. Kim and G. Lubec, Brain alpha-endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker and drug target?, Neurosci Lett, vol.310, pp.77-80, 2001.

S. H. Kim and G. Lubec, Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients, J Neural Transm Suppl, vol.61, pp.1-9, 2001.

J. Klucken, Y. Shin, E. Masliah, B. T. Hyman, and P. J. Mclean, Hsp70 Reduces alpha-synuclein aggregation and toxicity, J Biol Chem, vol.279, pp.25497-25502, 2004.

J. D. Knight and A. D. Miranker, Phospholipid catalysis of diabetic amyloid assembly, J Mol Biol, vol.341, pp.1175-1187, 2004.

J. D. Knight, J. A. Williamson, and A. D. Miranker, Interaction of membranebound islet amyloid polypeptide with soluble and crystalline insulin, Protein Sci, vol.17, pp.1850-1856, 2008.

S. Kumar, M. Birol, D. E. Schlamadinger, S. P. Wojcik, E. Rhoades et al., Foldamer-mediated manipulation of a pre-amyloid toxin, Nat Commun, vol.7, p.11412, 2016.

H. Lee, C. Choi, and S. Lee, Membrane-bound ?-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form, J Biol Chem, vol.277, pp.671-678, 2002.

J. H. Lee, C. S. Hong, S. Lee, J. E. Yang, Y. I. Park et al., Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of alpha-synuclein, PLoS ONE, vol.7, p.47580, 2012.

S. Lesage, M. Anheim, F. Letournel, L. Bousset, A. Honore et al., G51D alpha-synuclein mutation causes a novel parkinsonian-pyramidal syndrome, Ann Neurol, vol.73, pp.459-471, 2013.

F. Liu, J. L. Nguyen, J. D. Hulleman, L. Li, and J. Rochet, Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease, J Neurochem, vol.105, pp.2435-2453, 2008.

T. F. Outeiro, J. Klucken, K. E. Strathearn, F. Liu, P. Nguyen et al., Small heat shock proteins protect against alpha-synucleininduced toxicity and aggregation, Biochem Biophys Res Commun, vol.351, pp.631-638, 2006.

A. P. Pandey, F. Haque, J. C. Rochet, and J. S. Hovis, Clustering of alpha-synuclein on supported lipid bilayers: role of anionic lipid, protein, and divalent ion concentration, Biophys J, vol.96, pp.540-551, 2009.

S. Petrucci, M. Ginevrino, and E. M. Valente, Phenotypic spectrum of alpha-synuclein mutations: new insights from patients and cellular models, Parkinsonism Relat Disord, vol.22, issue.1, 2016.

M. H. Polymeropoulos, C. Lavedan, E. Leroy, S. E. Ide, A. Dehejia et al., Mutation in the ?-synuclein gene identified in families with Parkinson's disease, Science, vol.276, pp.2045-2047, 1997.

N. P. Reynolds, A. Soragni, M. Rabe, D. Verdes, E. Liverani et al., Mechanism of membrane interaction and disruption by alpha-synuclein, J Am Chem Soc, vol.133, pp.19366-19375, 2011.

P. S. Sastry, Lipids of nervous tissue: composition and metabolism, Prog Lipid Res, vol.24, pp.69-176, 1985.

K. Seidel, L. Schols, S. Nuber, E. Petrasch-parwez, K. Gierga et al., First appraisal of brain pathology owing to A30P mutant alpha-synuclein, Ann Neurol, vol.67, pp.684-689, 2010.

R. Sharon, I. Bar-joseph, G. E. Mirick, C. N. Serhan, and D. J. Selkoe, Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies, J Biol Chem, vol.278, pp.49874-49881, 2003.

A. B. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague et al., Alpha-Synuclein locus triplication causes Parkinson's disease, Science, vol.302, p.841, 2003.

M. G. Spillantini, M. L. Schmidt, V. Lee, J. Q. Trojanowski, R. Jakes et al., ) ?-Synuclein in lewy bodies, Nature, vol.388, pp.839-840, 1997.

S. Takamori, M. Holt, K. Stenius, E. A. Lemke, M. Gronborg et al., Molecular anatomy of a trafficking organelle, Cell, vol.127, pp.831-846, 2006.

F. X. Theillet, A. Binolfi, B. Bekei, A. Martorana, H. M. Rose et al., Structural disorder of monomeric alpha-synuclein persists in mammalian cells, Nature, vol.530, pp.45-50, 2016.

B. D. Van-rooijen, M. M. Claessens, and V. Subramaniam, Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core, Biochim Biophys Acta, vol.1788, pp.1271-1278, 2009.

L. L. Venda, S. J. Cragg, V. L. Buchman, and R. Wade-martins, ) alpha-Synuclein and dopamine at the crossroads of Parkinson's disease, Trends Neurosci, vol.33, pp.559-568, 2010.

M. J. Volles, S. Lee, J. Rochet, M. D. Shtilerman, T. T. Ding et al., Vesicle permeabilization by protofibrillar ?-synuclein: implications for the pathogenesis and treatment of Parkinson's disease, Biochemistry, vol.40, pp.7812-7819, 2001.

D. G. Walker, L. F. Lue, C. H. Adler, H. A. Shill, J. N. Caviness et al., Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type histopathology in human brains, Exp Neurol, vol.240, pp.190-204, 2013.

P. H. Weinreb, W. Zhen, A. W. Poon, K. A. Conway, and P. T. Lansbury, NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded, Biochemistry, vol.35, pp.13709-13715, 1996.

W. S. Woods, J. M. Boettcher, D. H. Zhou, K. D. Kloepper, K. L. Hartman et al., Conformation-specific binding of alphasynuclein to novel protein partners detected by phage display and NMR spectroscopy, J Biol Chem, vol.282, pp.34555-34567, 2007.

D. Ysselstein, M. Joshi, V. Mishra, A. M. Griggs, J. M. Asiago et al., Effects of impaired membrane interactions on alpha-synuclein aggregation and neurotoxicity, Neurobiol Dis, vol.79, pp.150-163, 2015.

H. Zhang, A. Griggs, J. C. Rochet, and L. A. Stanciu, In vitro study of alphasynuclein protofibrils by cryo-EM suggests a Cu(2+)-dependent aggregation pathway, Biophys J, vol.104, pp.2706-2713, 2013.