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Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Abstract : Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebusmurinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.
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Marie-Helene Canron, Martine Perret, Anne Vital, Erwan Bézard, Benjamin Dehay. Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate. Scientific Reports, Nature Publishing Group, 2012, 2, pp.910. ⟨10.1038/srep00910⟩. ⟨inserm-02439330⟩



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