Parkinson's disease: Mechanisms and models, Neuron, vol.39, pp.889-909, 2003. ,
Recent advances in the genetics of Parkinson's disease, Annu Rev Genomics Hum Genet, vol.12, pp.301-325, 2011. ,
Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome, Acta Neurol Scand, vol.89, pp.347-352, 1994. ,
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase, Nat Genet, vol.38, pp.1184-1191, 2006. ,
Italian Parkinson Genetics Network (2007) ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease, Neurology, vol.68, pp.1557-1562 ,
Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism, Hum Mutat, vol.32, pp.956-964, 2011. ,
Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9), Clin Genet, 2011. ,
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2, Biochem Biophys Res Commun, vol.383, issue.2, pp.198-202, 2009. ,
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity, Nat Genet, vol.41, pp.308-315, 2009. ,
Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ERstress induced cell death, Hum Mol Genet, vol.20, pp.3565-3577, 2011. ,
Pathogenic lysosomal depletion in Parkinson's disease, J Neurosci, vol.30, pp.12535-12544, 2010. ,
Lysosomal membrane permeabilization in Parkinson disease, Autophagy, vol.7, pp.98-100, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02439189
Parkinson's disease, proteins, and prions: Milestones, Mov Disord, vol.26, pp.1056-1071, 2011. ,
Etiology and pathogenesis of Parkinson's disease, Mov Disord, vol.26, pp.1049-1055, 2011. ,
In search of an "autophagomometer, Autophagy, vol.5, pp.585-589, 2009. ,
Lysosomal membrane permeabilization in cell death, Oncogene, vol.27, pp.6434-6451, 2008. ,
Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells, J Biol Chem, vol.279, pp.39982-39988, 2004. ,
Neuronal pigmented autophagic vacuoles: Lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease, J Neurochem, vol.106, pp.24-36, 2008. ,
Lysosomes: Fusion and function, Nat Rev Mol Cell Biol, vol.8, pp.622-632, 2007. ,
Membrane dynamics and the biogenesis of lysosomes, Mol Membr Biol, vol.20, issue.2, pp.141-154, 2003. ,
Molecular and cellular basis of lysosomal transmembrane protein dysfunction, Biochim Biophys Acta, vol.1793, pp.636-649, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00415318
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo, PLoS Genet, vol.6, p.1001026, 2010. ,
Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions, Neurobiol Dis, vol.35, pp.385-398, 2009. ,
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews, N Engl J Med, vol.351, pp.1972-1977, 2004. ,
Glucocerebrosidase is present in ?-synuclein inclusions in Lewy body disorders, Acta Neuropathol, vol.120, pp.641-649, 2010. ,
Gaucher disease glucocerebrosidase and ?-synuclein form a bidirectional pathogenic loop in synucleinopathies, Cell, vol.146, pp.37-52, 2011. ,
Alpha-Synuclein is degraded by both autophagy and the proteasome, J Biol Chem, vol.278, pp.25009-25013, 2003. ,
Lysosomal degradation of alpha-synuclein in vivo, J Biol Chem, vol.285, pp.13621-13629, 2010. ,
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy, Science, vol.305, pp.1292-1295, 2004. ,
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy, J Clin Invest, vol.118, pp.777-788, 2008. ,
Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases, J Biol Chem, vol.286, pp.28080-28088, 2011. ,
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species, Biochemistry, vol.47, pp.9678-9687, 2008. ,
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions, J Neurochem, vol.113, pp.1263-1274, 2010. ,
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission, Neurobiol Dis, vol.42, pp.360-367, 2011. ,
A deadly spread: Cellular mechanisms of ?-synuclein transfer, Cell Death Differ, vol.18, pp.1425-1433, 2011. ,
Fighting neurodegeneration with rapamycin: Mechanistic insights, Nat Rev Neurosci, vol.12, pp.437-452, 2011. ,