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Article Dans Une Revue Scientific Reports Année : 2012

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques

Résumé

Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.
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Dates et versions

inserm-02439214 , version 1 (14-01-2020)

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Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bézard. Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques. Scientific Reports, 2012, 2, pp.253. ⟨10.1038/srep00253⟩. ⟨inserm-02439214⟩

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