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Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques

Abstract : Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.
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https://www.hal.inserm.fr/inserm-02439214
Contributor : Benjamin Dehay <>
Submitted on : Tuesday, January 14, 2020 - 3:05:55 PM
Last modification on : Thursday, November 12, 2020 - 9:30:16 AM
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Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bézard. Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques. Scientific Reports, Nature Publishing Group, 2012, 2, pp.253. ⟨10.1038/srep00253⟩. ⟨inserm-02439214⟩

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