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Membrane perturbation by an external electric field: a mechanism to permit molecular uptake

Abstract : Electropermeabilisation is a well established physical method, based on the application of electric pulses, which induces the transient permeabilisation of the cell membrane. External molecules, otherwise nonpermeant, can enter the cell. Electropermeabilisation is now in use for the delivery of a large variety of molecules, as drugs and nucleic acids. Therefore, the method has great potential in the fields of cancer treatment and gene therapy. However many open questions about the underlying physical mechanisms involved remain to be answered or fully elucidated. In particular, the induced changes by the effects of the applied field on the membrane structure are still far from being fully understood. The present review focuses on questions related to the current theories, i.e. the basic physical processes responsible for the electropermeabilisation of lipid membranes. It also addresses recent findings using molecular dynamics simulations as well as experimental studies of the effect of the field on membrane components.
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https://www.hal.inserm.fr/inserm-02439124
Contributor : Jean-Michel Escoffre Connect in order to contact the contributor
Submitted on : Tuesday, January 14, 2020 - 2:48:12 PM
Last modification on : Wednesday, October 20, 2021 - 3:47:03 AM

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Jean-Michel Escoffre, David S. Dean, Marie Hubert, Marie-Pierre Rols, Cyril Favard. Membrane perturbation by an external electric field: a mechanism to permit molecular uptake. European Biophysics Journal, Springer Verlag (Germany), 2007, 36 (8), pp.973-983. ⟨10.1007/s00249-007-0194-7⟩. ⟨inserm-02439124⟩

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