A. Kepecs and G. Fishell, Interneuron cell types are fit to function, Nature, vol.505, pp.318-326, 2014.

R. Tremblay, S. Lee, and B. Rudy, GABAergic interneurons in the neocortex: from cellular properties to circuits, Neuron, vol.91, pp.260-292, 2016.

T. F. Freund and I. Katona, Perisomatic inhibition, Neuron, vol.56, pp.33-42, 2007.

H. Hu, J. Gan, P. Jonas, and . Interneurons, Fast-spiking, parvalbumin(+) GABAergic interneurons: from cellular design to microcircuit function, Science, vol.345, p.1255263, 2014.

L. Roux and G. Buzsaki, Tasks for inhibitory interneurons in intact brain circuits, Neuropharmacology, vol.88, pp.10-23, 2015.

A. Maffei, Fifty shades of inhibition, Curr. Opin. Neurobiol, vol.43, pp.43-47, 2017.

D. A. Lewis, T. Hashimoto, and D. W. Volk, Cortical inhibitory neurons and schizophrenia, Nat. Rev. Neurosci, vol.6, pp.312-324, 2005.

O. Marin, Interneuron dysfunction in psychiatric disorders, Nat. Rev. Neurosci, vol.13, pp.107-120, 2012.

J. E. Lisman, Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia, Trends Neurosci, vol.31, pp.234-242, 2008.

K. Nakazawa, GABAergic interneuron origin of schizophrenia pathophysiology, Neuropharmacology, vol.62, pp.1574-1583, 2012.

S. B. Nelson and V. Valakh, Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders, Neuron, vol.87, pp.684-698, 2015.

J. T. Coyle, A. Basu, M. Benneyworth, D. Balu, and G. Konopaske, Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications, Handb. Exp. Pharmacol, pp.267-295, 2012.

G. Gonzalez-burgos and D. A. Lewis, NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia, Schizophr. Bull, vol.38, pp.950-957, 2012.

B. Moghaddam and J. H. Krystal, Capturing the angel in "Angel Dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans, Schizophr. Bull, vol.38, pp.942-949, 2012.

P. Paoletti, C. Bellone, and Q. Zhou, NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease, Nat. Rev. Neurosci, vol.14, pp.383-400, 2013.

D. H. Hackos, Positive allosteric modulators of GluN2A-containing NMDARs with distinct modes of action and impacts on circuit function, Neuron, vol.89, pp.983-999, 2016.

D. H. Hackos and J. E. Hanson, Diverse modes of NMDA receptor positive allosteric modulation: mechanisms and consequences, Neuropharmacology, vol.112, pp.34-45, 2017.

B. Tasic, Adult mouse cortical cell taxonomy revealed by single cell transcriptomics, Nat. Neurosci, vol.19, pp.335-346, 2016.

A. Zeisel, Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq, Science, vol.347, pp.1138-1142, 2015.

P. Paoletti, P. Ascher, and J. Neyton, High-affinity zinc inhibition of NMDA NR1-NR2A receptors, J. Neurosci, vol.17, pp.5711-5725, 1997.
URL : https://hal.archives-ouvertes.fr/hal-00139995

J. E. Hanson, Chronic GluN2B antagonism disrupts behavior in wildtype mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models, J. Neurosci, vol.34, pp.8277-8288, 2014.

G. Liu, S. Choi, and R. W. Tsien, Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices, Neuron, vol.22, pp.395-409, 1999.

D. M. Kullmann and F. Asztely, Extrasynaptic glutamate spillover in the hippocampus: evidence and implications, Trends Neurosci, vol.21, pp.8-14, 1998.

D. A. Baker, Z. X. Xi, H. Shen, C. J. Swanson, and P. W. Kalivas, The origin and neuronal function of in vivo nonsynaptic glutamate, J. Neurosci, vol.22, pp.9134-9141, 2002.

L. Meur, K. Galante, M. Angulo, M. C. Audinat, and E. , Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus, J. Physiol, vol.580, pp.373-383, 2007.

P. I. Ortinski, J. R. Turner, and R. C. Pierce, Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine selfadministration, J. Neurosci, vol.33, pp.9451-9461, 2013.

N. V. Povysheva and J. W. Johnson, Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons, J. Neurophysiol, vol.107, pp.2232-2243, 2012.

P. Cavelier and D. Attwell, Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices, J. Physiol, vol.564, pp.397-410, 2005.

A. V. Tzingounis and J. I. Wadiche, Glutamate transporters: confining runaway excitation by shaping synaptic transmission, Nat. Rev. Neurosci, vol.8, pp.935-947, 2007.

P. Marcaggi and D. Attwell, Role of glial amino acid transporters in synaptic transmission and brain energetics, Glia, vol.47, pp.217-225, 2004.

C. Murphy-royal, J. Dupuis, L. Groc, and S. H. Oliet, Astroglial glutamate transporters in the brain: regulating neurotransmitter homeostasis and synaptic transmission, J. Neurosci. Res, vol.95, pp.2140-2151, 2017.

N. Lozovaya, Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density, Brain Res, vol.1011, pp.195-205, 2004.

K. Moussawi, A. Riegel, S. Nair, and P. W. Kalivas, Extracellular glutamate: functional compartments operate in different concentration ranges, Front. Syst. Neurosci, vol.5, p.94, 2011.

K. Tanaka, Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1, Science, vol.276, pp.1699-1702, 1997.

K. P. Lehre and N. C. Danbolt, The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain, J. Neurosci, vol.18, pp.8751-8757, 1998.

L. P. Bjornsen, M. G. Hadera, Y. Zhou, N. C. Danbolt, and U. Sonnewald, The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse, J. Neurochem, vol.128, pp.641-649, 2014.

N. C. Danbolt, Glutamate uptake, Prog. Neurobiol, vol.65, pp.1-105, 2001.

Y. Zhou and N. C. Danbolt, GABA and glutamate transporters in brain, Front. Endocrinol, vol.4, p.165, 2013.

F. A. Chaudhry, Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry, Neuron, vol.15, pp.711-720, 1995.

J. D. Rothstein, Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression, Nature, vol.433, pp.73-77, 2005.

M. Bellesi, M. Melone, A. Gubbini, S. Battistacci, and F. Conti, GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats, Glia, vol.57, pp.703-713, 2009.

H. W. Shen, M. D. Scofield, H. Boger, M. Hensley, and P. W. Kalivas, Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse, J. Neurosci, vol.34, pp.5649-5657, 2014.

J. L. Arriza, Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex, J. Neurosci, vol.14, pp.5559-5569, 1994.

F. Asztely, G. Erdemli, and D. M. Kullmann, Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake, Neuron, vol.18, pp.281-293, 1997.

J. S. Diamond, D. E. Bergles, and C. E. Jahr, Glutamate release monitored with astrocyte transporter currents during LTP, Neuron, vol.21, pp.425-433, 1998.

S. Kojima, Optical detection of synaptically induced glutamate transport in hippocampal slices, J. Neurosci, vol.19, pp.2580-2588, 1999.

S. Hestrin, P. Sah, and R. A. Nicoll, Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices, Neuron, vol.5, pp.247-253, 1990.

H. Nie and H. R. Weng, Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats, J. Neurophysiol, vol.103, pp.2570-2580, 2010.

K. Shimamoto, DL-Threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters, Mol. Pharmacol, vol.53, pp.195-201, 1998.

A. Z. Harris and D. L. Pettit, Recruiting extrasynaptic NMDA receptors augments synaptic signaling, J. Neurophysiol, vol.99, pp.524-533, 2008.

J. Garthwaite, Cellular uptake disguises action of L-glutamate on N-methyl-Daspartate receptors, Br. J. Pharmacol, vol.85, pp.297-307, 1985.

E. O. Mann and I. Mody, Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons, Nat. Neurosci, vol.13, pp.205-212, 2010.

M. A. Herman and C. E. Jahr, Extracellular glutamate concentration in hippocampal slice, J. Neurosci, vol.27, pp.9736-9741, 2007.

H. Monyer, N. Burnashev, D. J. Laurie, B. Sakmann, and P. H. Seeburg, Developmental and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron, vol.12, pp.529-540, 1994.

J. Von-engelhardt, GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice, Front. Cell Neurosci, vol.9, p.95, 2015.

R. E. Perszyk, GluN2D-Containing N-methyl-D-aspartate receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity, Mol. Pharmacol, vol.90, pp.689-702, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01541353

S. A. Swanger, A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons, ACS Chem. Neurosci, vol.9, pp.306-319, 2018.

C. J. Hatton and P. Paoletti, Modulation of triheteromeric NMDA receptors by N-terminal domain ligands, Neuron, vol.46, pp.261-274, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00139989

Y. Yang and M. A. Xu-friedman, Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus, J. Neurophysiol, vol.113, pp.3634-3645, 2015.

K. Zheng and D. A. Rusakov, Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil, Biophys. J, vol.108, pp.2457-2464, 2015.

J. D. Clements, R. A. Lester, G. Tong, C. E. Jahr, and G. L. Westbrook, The time course of glutamate in the synaptic cleft, Science, vol.258, pp.1498-1501, 1992.

J. S. Diamond and C. E. Jahr, Transporters buffer synaptically released glutamate on a submillisecond time scale, J. Neurosci, vol.17, pp.4672-4687, 1997.

J. S. Diamond, Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: transmitter uptake gets faster during development, J. Neurosci, vol.25, pp.2906-2916, 2005.

Y. W. Wu, S. Grebenyuk, T. J. Mchugh, D. A. Rusakov, and A. Semyanov, Backpropagating action potentials enable detection of extrasynaptic glutamate by NMDA receptors, Cell Rep, vol.1, pp.495-505, 2012.

D. N. Chiu and C. E. Jahr, Extracellular glutamate in the nucleus accumbens is nanomolar in both synaptic and non-synaptic compartments, Cell Rep, vol.18, pp.2576-2583, 2017.

N. Cholet, L. Pellerin, P. J. Magistretti, and E. Hamel, Similar perisynaptic glial localization for the Na + ,K + -ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex, Cereb. Cortex, vol.12, pp.515-525, 2002.

T. Papouin, Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists, Cell, vol.150, pp.633-646, 2012.

S. H. Devries, Exocytosed protons feedback to suppress the Ca 2+ current in mammalian cone photoreceptors, Neuron, vol.32, pp.1107-1117, 2001.

A. M. Vergnano, Zinc dynamics and action at excitatory synapses, Neuron, vol.82, pp.1101-1114, 2014.

K. Sapkota, Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives, Neuropharmacology, vol.125, pp.64-79, 2017.

H. Yuan, Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects, Neuron, vol.85, pp.1305-1318, 2015.

P. Sah, S. Hestrin, and R. A. Nicoll, Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons, Science, vol.246, pp.815-818, 1989.

P. Cavelier, V. Hamann, D. Rossi, P. Mobbs, and D. Attwell, Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences, Prog. Biophys. Mol. Biol, vol.87, pp.3-16, 2005.

B. Serraz, T. Grand, and P. Paoletti, Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations, Neuropharmacology, vol.109, pp.196-204, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01331195