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The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells

Abstract : The amount of inosine monophosphate dehydrogenase (IMPDH), a pivotal enzyme for the biosynthesis of the guanosine tri-phosphate (GTP), is frequently increased in tumor cells. The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH. We recently showed that IMPDH inhibition led to a necrotic signal requiring the activation of Cdc42.
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https://www.hal.inserm.fr/inserm-02438817
Contributor : Philippe Pourquier Connect in order to contact the contributor
Submitted on : Tuesday, January 14, 2020 - 1:19:32 PM
Last modification on : Wednesday, March 30, 2022 - 2:38:32 PM

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Gwendaline Guidicelli, Benjamin Chaigne-Delalande, Marie-Sarah Dilhuydy, Benoît Pinson, Walid Mahfouf, et al.. The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells. PLoS ONE, Public Library of Science, 2009, 4 (5), pp.e5493. ⟨10.1371/journal.pone.0005493⟩. ⟨inserm-02438817⟩

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