The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells - Archive ouverte HAL Access content directly
Journal Articles PLoS ONE Year : 2009

The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells

(1) , (2) , (3) , (4) , (5) , (6) , (7) , (8) , (9) , (10)
1
2
3
4
5
6
7
8
9
10

Abstract

The amount of inosine monophosphate dehydrogenase (IMPDH), a pivotal enzyme for the biosynthesis of the guanosine tri-phosphate (GTP), is frequently increased in tumor cells. The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH. We recently showed that IMPDH inhibition led to a necrotic signal requiring the activation of Cdc42.

Dates and versions

inserm-02438817 , version 1 (14-01-2020)

Identifiers

Cite

Gwendaline Guidicelli, Benjamin Chaigne-Delalande, Marie-Sarah Dilhuydy, Benoît Pinson, Walid Mahfouf, et al.. The Necrotic Signal Induced by Mycophenolic Acid Overcomes Apoptosis-Resistance in Tumor Cells. PLoS ONE, 2009, 4 (5), pp.e5493. ⟨10.1371/journal.pone.0005493⟩. ⟨inserm-02438817⟩
4093 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More