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Protein arginine ( N )-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins

Abstract : PRMT7 belongs to the protein arginine methyl-transferases family. We show that downregulation of PRMT7alpha and beta isoforms in DC-3F hamster cells was associated with increased sensitivity to the Top1 inhibitor camptothecin (CPT). This effect was not due to a change in Top1 contents or catalytic activity, or to a difference in the reversal of DNA breaks. Overexpression of PRMT7alpha and beta in DC-3F cells had no effect on CPT sensitivity, whereas it conferred a resistance to DC-3F/9-OH-E cells for which both isoforms are reduced by two- to three-fold as compared to DC-3F parental cells. Finally, downregulation of the human PRMT7 could also sensitize HeLa cells to CPT, suggesting that it could be used as a target to potentiate CPT derivatives.
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https://www.hal.inserm.fr/inserm-02438814
Contributor : Philippe Pourquier <>
Submitted on : Tuesday, January 14, 2020 - 1:18:29 PM
Last modification on : Wednesday, October 14, 2020 - 4:14:15 AM

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Vincent Verbiest, Danièle Montaudon, Michel Tautu, Joyce Moukarzel, Jean-Pierre Portail, et al.. Protein arginine ( N )-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins. FEBS Letters, Wiley, 2008, 582 (10), pp.1483-1489. ⟨10.1016/j.febslet.2008.03.031⟩. ⟨inserm-02438814⟩

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