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Inhibitory Feature of the Proprotein Convertases Prosegments

Abstract : The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
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Yannick Bontemps, Marion Lapierre, Geraldine Siegfried, Fabien Calvo, Abdel-Majid Khatib. Inhibitory Feature of the Proprotein Convertases Prosegments. Medicinal Chemistry, Bentham Science Publishers, 2008, 4 (2), pp.116 - 120. ⟨10.2174/157340608783789176⟩. ⟨inserm-02438806⟩



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