Cp subst ), 4.09 (t, J = 1.9 Hz, 2H, Cp subst ), 4.11 (s, 5H, Cp), 6.67 (s, 1H, NH), 6.94 (d, J = 8.7 Hz, 2H, 2CH Ar ), 7.10-7.25 (m, 4H, 3CH Ar and NH), 7.32 (t, J = 7.3 Hz, 2H, 2CH Ar ), 7.46 (d, J = 8.7 Hz, 2H, 2CH Ar ), vol.2 ,
(CvO), 174.2 (CvO). IR (KBr, ? max /cm ?1 ): 3410 (N-H stretch, 126.1 (C Ar ), 128.3 (C Ar ), 128.7 (C Ar ), 129.4 (C Ar ), 136.5 (CvC), vol.9, p.562 ,
, To a solution of TAM-OPOA (2.0 mmol, 0.910 g) in 15 mL of anhydrous THF, cooled to 0°C, ClCO 2 Et (3.0 mmol, 0.29 mL) and Et 3 N (3.4 mmol, 0.47 mL) were added and the mixture was stirred for 10 min. The solid was filtered off and an excess of NaNH 2 was added to the filtrate. After 30 min of stirring, 20 mL of water was slowly added. The product was extracted with AcOEt, and the organic layer was dried over MgSO 4 , filtered and evaporated. The crude was purified by column chromatography using mixtures of AcOEt and petroleum ether. 0.363 g (40%) of TAM-PSA was isolated
69 (s, 1H, NH). 13 C-NMR (75 MHz, (CD 3 ) 2 SO, ppm): ? 13.3 (CH 3 ), CD 3 ) 2 SO, ppm): ? 0.83 (t, J = 7.4 Hz, 3H, CH 3 ), 1.21 (m, 4H, 2CH 2 ), 1.40-1.51 (m, 4H, 2CH 2 ), 1.98 (t, J = 7.4 Hz, 2H, CH 2 ), 2.18 (t, J = 7.5 Hz, 2H, CH 2 ), 2.36 (q, J = 7.4 Hz, 2H, CH 2 ), vol.6, p.1400 ,
, N stretch). MS (CI, p.472
,
, We also thank the National Council of Science and Technology of Mexico (CONACyT) for the PhD scholarship for JJCM. Notes and references
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