T. and J. , Cp subst ), 4.09 (t, J = 1.9 Hz, 2H, Cp subst ), 4.11 (s, 5H, Cp), 6.67 (s, 1H, NH), 6.94 (d, J = 8.7 Hz, 2H, 2CH Ar ), 7.10-7.25 (m, 4H, 3CH Ar and NH), 7.32 (t, J = 7.3 Hz, 2H, 2CH Ar ), 7.46 (d, J = 8.7 Hz, 2H, 2CH Ar ), vol.2

2. Hz and . Ar, (CvO), 174.2 (CvO). IR (KBr, ? max /cm ?1 ): 3410 (N-H stretch, 126.1 (C Ar ), 128.3 (C Ar ), 128.7 (C Ar ), 129.4 (C Ar ), 136.5 (CvC), vol.9, p.562

, To a solution of TAM-OPOA (2.0 mmol, 0.910 g) in 15 mL of anhydrous THF, cooled to 0°C, ClCO 2 Et (3.0 mmol, 0.29 mL) and Et 3 N (3.4 mmol, 0.47 mL) were added and the mixture was stirred for 10 min. The solid was filtered off and an excess of NaNH 2 was added to the filtrate. After 30 min of stirring, 20 mL of water was slowly added. The product was extracted with AcOEt, and the organic layer was dried over MgSO 4 , filtered and evaporated. The crude was purified by column chromatography using mixtures of AcOEt and petroleum ether. 0.363 g (40%) of TAM-PSA was isolated

. Mhz, 69 (s, 1H, NH). 13 C-NMR (75 MHz, (CD 3 ) 2 SO, ppm): ? 13.3 (CH 3 ), CD 3 ) 2 SO, ppm): ? 0.83 (t, J = 7.4 Hz, 3H, CH 3 ), 1.21 (m, 4H, 2CH 2 ), 1.40-1.51 (m, 4H, 2CH 2 ), 1.98 (t, J = 7.4 Hz, 2H, CH 2 ), 2.18 (t, J = 7.5 Hz, 2H, CH 2 ), 2.36 (q, J = 7.4 Hz, 2H, CH 2 ), vol.6, p.1400

, N stretch). MS (CI, p.472

H. and O. ,

, We also thank the National Council of Science and Technology of Mexico (CONACyT) for the PhD scholarship for JJCM. Notes and references

M. Patra and G. Gasser, ChemBioChem, vol.15, pp.1232-1252, 2012.

S. S. David and E. Meggers, Curr. Opin. Chem. Biol, vol.12, pp.194-196, 2008.

G. Jaouen, Bioorganometallics, 2006.

, Medicinal Organometallic Chemistry, p.32, 2010.

E. Meggers, Chem. Commun, pp.1001-1010, 2009.

G. Gasser, I. Ott, and N. Metzler-nolte, J. Med. Chem, vol.54, pp.3-25, 2011.

S. Top, J. Tang, A. Vessières, D. Carrez, C. Provote et al., Chem. Commun, pp.955-956, 1996.

G. Jaouen, S. Top, A. Vessières, G. Leclercq, J. Quivy et al., C. R. Acad. Sci, pp.89-93, 2000.

E. A. Hillard, A. Vessières, S. Top, P. Pigeon, K. Kowalski et al., J. Organomet. Chem, vol.692, pp.1315-1326, 2007.

G. Jaouen, S. Top, A. Vessières, G. Leclercq, and M. J. Mcglinchey, Curr. Med. Chem, vol.11, pp.2505-2517, 2004.

S. Top, A. Vessières, G. Leclercq, J. Quivy, J. Tang et al., Chem.-Eur. J, vol.9, pp.5223-5236, 2003.

A. Nguyen, A. Vessières, E. A. Hillard, S. Top, P. Pigeon et al., Chimia, vol.61, pp.716-724, 2007.

B. D. Lehmann, J. A. Bauer, X. Chen, M. E. Sanders, A. B. Chakravarthy et al., J. Clin. Invest, vol.121, pp.2750-2767, 2011.

D. A. Ferraro, N. Gaborit, R. Maron, H. Cohen-dyashi, Z. Porat et al., Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.1815-1829, 2013.

E. A. Hillard, A. Vessières, L. Thouin, G. Jaouen, and C. Amatore, Angew. Chem., Int. Ed, vol.45, pp.285-290, 2006.

A. Nguyen, S. Top, P. Pigeon, A. Vessières, E. A. Hillard et al., Chem.-Eur. J, vol.15, pp.684-696, 2009.

A. Vessières, S. Top, W. Beck, E. Hillard, and G. Jaouen, Dalton Trans, pp.529-541, 2006.

D. Pla?uk, A. Vessières, E. A. Hillard, O. Buriez, E. Labbé et al., J. Med. Chem, vol.52, pp.4964-4967, 2009.

A. Vessières, S. Top, P. Pigeon, E. A. Hillard, L. Boubeker et al., J. Med. Chem, vol.48, pp.3937-3940, 2005.

E. A. Hillard, A. Vessières, F. L. Bideau, D. Pla?uk, D. Spera et al., Chem. Med. Chem, vol.1, pp.551-559, 2006.

O. Zekri, E. A. Hillard, S. Top, A. Vessières, P. Pigeon et al., Dalton Trans, pp.4318-4326, 2009.

E. A. Hillard, F. C. Caxico-de-abreu, D. C. Ferreira, G. Jaouen, M. O. Goulart et al., Chem. Commun, pp.2612-2628, 2008.

H. Hagen, P. Marzenell, E. Jentzsch, F. Wenz, M. R. Veldwijk et al., J. Med. Chem, vol.55, pp.924-934, 2012.

S. B. Baylin, Nat. Clin. Pract. Oncol, vol.2, pp.4-11, 2005.

W. J. Pearce, Transl. Stroke Res, vol.2, pp.243-247, 2011.

M. Paris, M. Porcelloni, M. Binaschi, and D. Fattori, J. Med. Chem, vol.51, pp.1505-1529, 2008.

H. , D. Schutter, and S. Nuyts, Anti-Cancer Agents Med. Chem, vol.9, pp.99-109, 2009.

J. E. Bolden, M. J. Peart, and R. W. Johnstone, Nat. Rev. Drug Discovery, vol.5, pp.769-784, 2006.

P. A. Marks and R. Breslow, Nat. Biotechnol, vol.25, pp.84-90, 2007.

Y. Zhang, H. Fang, J. Feng, Y. Jia, X. Wang et al., J. Med. Chem, vol.54, pp.5532-5539, 2011.

K. C. Park, S. W. Kim, J. H. Park, E. H. Song, J. W. Yang et al., Cancer Sci, vol.102, pp.343-350, 2011.

P. N. Münster, T. Troso-sandoval, N. Rosen, R. Rifkind, P. A. Marks et al., Cancer Res, vol.61, pp.8492-8497, 2001.

P. Bali, M. Pranpat, R. Swaby, W. Fiskus, H. Yamaguchi et al., Clin Cancer Res, vol.11, pp.6382-6389, 2005.

T. A. Miller, D. J. Witter, and S. Blevedere, J. Med. Chem, vol.46, pp.5097-5116, 2003.

S. Belvedere, D. J. Witter, J. Yan, J. P. Secrist, V. Richon et al., Bioorg. Med. Chem. Lett, vol.17, pp.3969-3971, 2007.

A. P. Kozikowski, S. Tapadar, D. N. Luchini, K. Kim, and D. D. Billadeau, J. Med. Chem, vol.51, pp.4370-4373, 2008.

L. E. Tavera-mendoza, T. D. Quach, B. Dabbas, J. Hudon, X. Liao et al., Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.8250-8255, 2008.

F. Oger, A. Lecorgne, E. Sala, V. Nardese, F. Demay et al., J. Med. Chem, vol.53, pp.1937-1950, 2010.

D. Griffith, M. P. Morgan, and C. J. Marmion, Chem. Commun, pp.6735-6737, 2009.

J. Spencer, J. Amin, M. Wang, G. Packham, S. S. Syed-alwi et al., ACS Med. Chem. Lett, vol.2, pp.358-362, 2011.

A. V. Bieliauskas, S. V. Weerasinghe, and M. K. Pflum, Bioorg. Med. Chem. Lett, vol.17, pp.2216-2219, 2007.

S. Hanessian, L. Auzzas, G. Giannini, M. Marzim, W. Cabri et al., Bioorg. Med. Chem. Lett, vol.17, pp.6261-6265, 2007.

C. B. Botta, W. Cabri, E. Cini, L. De-cesare, C. Fattorusso et al., J. Med. Chem, vol.54, pp.2165-2182, 2011.

F. Dehmel, T. Ciossek, T. Maier, S. Weinbrenner, B. Schmidt et al., Bioorg. Med. Chem. Lett, vol.17, pp.4746-4752, 2007.

L. Hodges-gallagher, C. D. Valentine, S. E. Bader, and P. J. Kushner, Breast Cancer Res. Treat, vol.105, pp.297-309, 2007.

T. K. Owonikoko, S. S. Ramalingam, B. Kanterewicz, T. E. Balius, C. P. Belani et al., Int. J. Cancer, vol.126, pp.743-755, 2010.

C. S. Dietrich, V. L. Greenberg, C. P. Desimone, S. C. Modesitt, J. R. Van-nagell et al., Gynecol. Oncol, vol.116, pp.126-130, 2010.

Y. K. Shi, Z. H. Li, X. Q. Han, X. Q. Han, J. H. Yi et al., Cancer Chemother. Pharmacol, vol.66, pp.1131-1140, 2010.

P. N. Münster, K. T. Thurn, S. Thomas, P. Raha, M. Lacevic et al., Br. J. Cancer, vol.104, pp.1828-1835, 2011.

S. Thomas, K. T. Thurn, E. Biçaku, D. C. Marchion, and P. N. Münster, Breast Cancer Res, vol.130, pp.437-447, 2011.

A. Mai, M. Esposito, G. Sbardellat, and S. Massat, Org. Prep. Proced. Int, vol.33, pp.391-394, 2001.

Y. Okunoi, K. Horita, O. Yonemitsu, K. Shibata, and T. A. Amemiya, J. Chem. Soc., Perkin Trans. 1, pp.1115-1118, 1984.

L. Kubicova, K. Waisser, J. Kunes, K. Kralova, Z. Odlerova et al., Molecules, vol.5, pp.714-726, 2000.

T. B. Windholz and J. B. Clements, J. Org. Chem, vol.29, pp.3021-3023, 1964.

O. Buriez, E. Labbé, P. Pigeon, G. Jaouen, and C. Amatore, J. Electroanal. Chem, vol.619, pp.169-175, 2008.

P. Pigeon, S. Top, O. Zekri, E. A. Hillard, A. Vessières et al., J. Organomet. Chem, vol.694, pp.895-901, 2009.

M. Görmen, P. Pigeon, S. Top, A. Vessières, M. A. Plamont et al., MedChemComm, vol.1, pp.149-151, 2010.

J. J. Cázares-marinero, S. Top, and G. Jaouen, J. Organomet. Chem

A. Escande, A. Pillon, N. Servant, J. P. Cravedi, F. Larrea et al., Biochem. Pharmacol, vol.71, pp.1459-1469, 2006.

F. Vernon and J. H. Khorassani, Talanta, vol.25, pp.410-412, 1978.

M. Hojjatie, T. Cecconie, and H. Freiser, Anal. Chim. Acta, vol.199, pp.49-57, 1987.

B. K. Tait, K. E. Mdlalose, and I. Taljaard, Hydrometallurgy, vol.38, pp.1-6, 1995.

M. J. Miller, Chem. Rev, vol.89, pp.1563-1579, 1989.

D. Vincent, H. Schwal, and M. C. Vincent, Ann. Pharm. Fr, vol.17, pp.579-584, 1959.

D. M. Griffith, B. Szöcs, T. Keogh, K. Y. Suponitsky, E. Farkas et al., J. Inorg. Biochem, vol.105, pp.763-769, 2011.

Y. Sowa, T. Orita, S. Minimikawa, K. Nakano, T. Mizuno et al., Biochem. Biophys. Res. Commun, vol.241, pp.142-150, 1997.

R. Margueron, A. Licznar, G. Lazennec, F. Vignon, and V. Cavaillès, J. Endocrinol, vol.179, pp.41-53, 2003.

V. M. Richon, T. W. Sandhoff, R. A. Rifkind, and P. Marks, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.10014-10019, 2000.

A. Vessières, C. Corbet, J. M. Heldt, N. Lories, N. Jouy et al., J. Inorg. Biochem, vol.104, pp.503-511, 2010.

K. Jomova and M. Valko, Toxicology, vol.283, pp.65-87, 2011.

D. H. Kim, J. K. Kundu, and Y. J. Suth, Mol. Carcinog, vol.50, pp.222-234, 2011.

W. S. El-deiry, T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons et al., Cell, vol.75, pp.817-825, 1993.

A. Mallet and S. Pervaiz, Antioxid. Redox Signaling, vol.16, pp.1285-1294, 2012.

O. Payen, S. Top, A. Vessières, E. Brulé, A. Lauzier et al., J. Organomet. Chem, vol.696, pp.1049-1056, 2011.

, Dalton Transactions Paper