Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer genetics and cytogenetics, vol.12, pp.21-26, 1984. ,
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours, Nature, vol.359, issue.6391, pp.162-167, 1992. ,
Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target, Cancer Res, vol.56, issue.20, pp.4570-4574, 1996. ,
A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature, Cell Cycle, vol.7, issue.2, pp.250-256, 2008. ,
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulinlike growth factor binding protein 3, Mol Cell Biol, vol.24, issue.16, pp.7275-83, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-02438604
Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays, International journal of oncology, vol.20, issue.3, pp.441-51, 2002. ,
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin, Oncogene, vol.24, issue.15, pp.2512-2536, 2005. ,
NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma, Mol Cancer Res, vol.4, issue.11, pp.851-860, 2006. ,
The orphan nuclear receptor DAX1 is upregulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors, International journal of cancer, vol.118, issue.6, pp.1381-1390, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00172274
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma, Cancer cell, vol.9, issue.5, pp.405-421, 2006. ,
GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance, Oncogene, vol.28, issue.46, pp.4126-4158, 2009. ,
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells, Genes Dev, vol.24, issue.9, pp.916-948, 2010. ,
Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations, Sarcoma, 2011. ,
Gene expression profiling of human sarcomas: insights into sarcoma biology, Cancer research, vol.65, issue.20, pp.9226-9261, 2005. ,
A molecular function map of Ewing's sarcoma, PLoS ONE, vol.4, issue.4, p.5415, 2009. ,
Production and characterization of mouse monoclonal antibodies to wild-type and oncogenic FLI-1 proteins, Hybridoma, vol.16, issue.5, pp.457-64, 1997. ,
Mesenchymal stem cell features of ewing tumors, Cancer cell, vol.11, issue.5, pp.421-430, 2007. ,
The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function, PLoS ONE, vol.4, issue.3, p.4932, 2009. ,
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector, EMBO Rep, vol.4, issue.6, pp.609-624, 2003. ,
Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression, Oncogene, vol.20, issue.25, pp.3258-65, 2001. ,
ZH performed the experiments and analyzed the data. GP and SB were involved in tumors processing and microarrays ,
FR performed in vivo drug experiments. DS, FT and OD wrote the paper ,