Skip to Main content Skip to Navigation
Journal articles

Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity

Abstract : Sarcomas are heterogeneous and aggressive mesenchymal tumors. Histological grading has so far been the best predictor for metastasis-free survival, but it has several limitations, such as moderate reproducibility and poor prognostic value for some histological types. To improve patient grading, we performed genomic and expression profiling in a training set of 183 sarcomas and established a prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome management. In a multivariate analysis, CINSARC predicts metastasis outcome in the training set and in an independent 127 sarcomas validation set. It is superior to the Fédération Francaise des Centres de Lutte Contre le Cancer grading system in determining metastatic outcome for sarcoma patients. Furthermore, it also predicts outcome for gastrointestinal stromal tumors (GISTs), breast carcinomas and lymphomas. Application of the signature will permit more selective use of adjuvant therapies for people with sarcomas, leading to decreased iatrogenic morbidity and improved outcomes for such individuals.
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02438669
Contributor : Franck Tirode <>
Submitted on : Tuesday, January 14, 2020 - 12:14:58 PM
Last modification on : Tuesday, July 21, 2020 - 3:58:53 AM
Long-term archiving on: : Wednesday, April 15, 2020 - 6:06:02 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Frédéric Chibon, Pauline Lagarde, Sebastien Salas, Gaëlle Pérot, Véronique Brouste, et al.. Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nature Medicine, Nature Publishing Group, 2010, 16 (7), pp.781-787. ⟨10.1038/nm.2174⟩. ⟨inserm-02438669⟩

Share

Metrics

Record views

329