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Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
Frédéric Chibon
1, 2
Pauline Lagarde
2, 1
Sebastien Salas
3
Gaëlle Pérot
2
Véronique Brouste
4
Franck Tirode
5
Carlo Lucchesi
6
Aurélien de Reyniès
7
Audrey Kauffmann
1
Binh Bui
8
Philippe Terrier
9
Sylvie Bonvalot
10
Axel Le Cesne
11
Dominique Vince-Ranchère
12
Jean-Yves Blay
12
Françoise Collin
13
Louis Guillou
14
Agnès Leroux
15
Jean-Michel Coindre
16
Alain Aurias
6
Frédéric Chibon 1, 2
Author
Pauline Lagarde 2, 1
Author
Sebastien Salas 3
Author
Gaëlle Pérot 2
Author
Véronique Brouste 4
Author
Franck Tirode 5
Mail :
Author
Carlo Lucchesi 6
Author
Aurélien de Reyniès 7
Author
Axel Le Cesne 11
Author
Dominique Vince-Ranchère 12
Author
Jean-Yves Blay 12
Author
Françoise Collin 13
Author
1
VINCO - Validation et identification de nouvelles cibles en oncologie (France)
- Université Bordeaux Segalen - Bordeaux 2 (146 rue Léo Saignat - 33076 Bordeaux cedex - France)
- Institut Bergonié - CRLCC Bordeaux (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U916 (101, rue de Tolbiac, 75013 Paris - France)
2
Institut Bergonié - CRLCC Bordeaux (France)
5
CRCL - Centre de Recherche en Cancérologie de Lyon (28 rue laennec Bat Cheney 69373 Cedex 08 Lyon - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- Centre Léon Bérard [Lyon] (28, rue Laennec 69373 LYON Cedex 08 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1052 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5286 (France)
6
U830 - Unité de génétique et biologie des cancers (Institut Curie
26, rue d'Ulm section de recherche
75248 Paris cedex 05 - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR_S 830 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- Institut Curie ( 26 rue d'Ulm - 75248 Paris Cedex 05 - France - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U830 (101, rue de Tolbiac, 75013 Paris - France)
7
Programme Cartes d'Identité des Tumeurs (CIT) (Paris - France)
- Ligue Nationale Contre le Cancer (France)
9
Département de biologie et pathologie médicales [Gustave Roussy] (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
10
CIC 1428 , CBT 507 - Centre d'Investigation Clinique en Biotherapie des cancers (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy : CBT507 (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1428 (101, rue de Tolbiac, 75013 Paris - France)
11
Département de médecine oncologique [Gustave Roussy] (Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
12
Centre Léon Bérard [Lyon] (28, rue Laennec 69373 LYON Cedex 08 - France)
13
CRLCC - CGFL - Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (1 Rue du Professeur Marion, 21000 Dijon - France)
14
Oncology - Pathology - Anatomy (Hochschulstrasse 4, 3012 Bern - Switzerland)
- Institute of Pathology (France)
- University of Bern (Hochschulstrasse 4, 3012 Bern, Switzerland - Switzerland)
15
CAV - Centre Alexis Vautrin (6 avenue de Bourgogne, 54519 Vandoeuvre les Nancy - France)
16
Service de Pathologie (229 Cours de l'Argonne 33000 Bordeaux - France)
- Institut Bergonié (France)
Abstract : Sarcomas are heterogeneous and aggressive mesenchymal tumors. Histological grading has so far been the best predictor for metastasis-free survival, but it has several limitations, such as moderate reproducibility and poor prognostic value for some histological types. To improve patient grading, we performed genomic and expression profiling in a training set of 183 sarcomas and established a prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome management. In a multivariate analysis, CINSARC predicts metastasis outcome in the training set and in an independent 127 sarcomas validation set. It is superior to the Fédération Francaise des Centres de Lutte Contre le Cancer grading system in determining metastatic outcome for sarcoma patients. Furthermore, it also predicts outcome for gastrointestinal stromal tumors (GISTs), breast carcinomas and lymphomas. Application of the signature will permit more selective use of adjuvant therapies for people with sarcomas, leading to decreased iatrogenic morbidity and improved outcomes for such individuals.
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Journal articles
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https://www.hal.inserm.fr/inserm-02438669
Contributor : Franck Tirode <>
Submitted on : Tuesday, January 14, 2020 - 12:14:58 PM
Last modification on : Friday, March 27, 2020 - 2:34:49 AM
Contributor : Franck Tirode <>
Submitted on : Tuesday, January 14, 2020 - 12:14:58 PM
Last modification on : Friday, March 27, 2020 - 2:34:49 AM
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- HAL Id : inserm-02438669, version 1
- DOI : 10.1038/nm.2174
- PUBMED : 20581836
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Citation
Frédéric Chibon, Pauline Lagarde, Sebastien Salas, Gaëlle Pérot, Véronique Brouste, et al.. Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nature Medicine, Nature Publishing Group, 2010, 16 (7), pp.781-787. ⟨10.1038/nm.2174⟩. ⟨inserm-02438669⟩
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