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Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors

Abstract : Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H-Dots) are demonstrated. H-Dots not only target GIST for image-guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H-Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice following surgical resection. More importantly, IM loaded H-Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H-Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.
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Submitted on : Tuesday, January 14, 2020 - 10:57:49 AM
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Homan Kang, Wesley Stiles, Yoonji Baek, Shinsuke Nomura, Kai Bao, et al.. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Advanced Materials, Wiley-VCH Verlag, 2019, pp.1905899. ⟨10.1002/adma.201905899⟩. ⟨inserm-02438324⟩



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