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[Topoisomerases I: new targets for the treatment of cancer and mechanisms of resistance].

Abstract : DNA topoisomerases I are ubiquitous enzymes that play a crucial role in DNA condensation, replication, transcription, and repair. Eukaryotic enzymes are highly conserved and specifically targeted by natural anticancer agents such as camptothecin and its derivatives. These drugs poison top 1 by inhibiting the enzyme via trapping of top 1 clivage complexes, which ultimately generate cell death. New camptothecin derivatives with better pharmacologic characteristics are under development. Understanding top 1 functions and structure will help to discover more specific and less toxic top 1 inhibitors in order to circumvent drug resistance.
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Contributor : Philippe Pourquier Connect in order to contact the contributor
Submitted on : Tuesday, January 14, 2020 - 10:37:11 AM
Last modification on : Wednesday, July 15, 2020 - 10:26:01 AM


  • HAL Id : inserm-02438250, version 1
  • PUBMED : 9932078



P. Pourquier, y Pommier. [Topoisomerases I: new targets for the treatment of cancer and mechanisms of resistance].. Bulletin du Cancer, John Libbey Eurotext, 1998, Spec No, pp.5-10. ⟨inserm-02438250⟩



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