Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BBA - Gene Structure and Expression Année : 1998

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

Yi Fan
  • Fonction : Auteur
Dirk Strumberg
  • Fonction : Auteur

Résumé

DNA topoisomerase I is essential for cellular metabolism and survival. It is also the target of a novel class of anticancer drugs active against previously refractory solid tumors, the camptothecins. The present review describes the topoisomerase I catalytic mechanisms with particular emphasis on the cleavage complex that represents the enzyme's catalytic intermediate and the site of action for camptothecins. Roles of topoisomerase I in DNA replication, transcription and recombination are also reviewed. Because of the importance of topoisomerase I as a chemotherapeutic target, we review the mechanisms of action of camptothecins and the other topoisomerase I inhibitors identified to date.

Dates et versions

inserm-02438240 , version 1 (14-01-2020)

Identifiants

Citer

Yves Pommier, Philippe Pourquier, Yi Fan, Dirk Strumberg. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. BBA - Gene Structure and Expression, 1998, 1400 (1-3), pp.83-106. ⟨10.1016/s0167-4781(98)00129-8⟩. ⟨inserm-02438240⟩
27 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More