, Glucocorticoid-induced thymocyte apoptosis is associated with endog enous endonuclease activation, Nature (Lond.), vol.284, pp.555-556, 1980.
The genetic regulation of apoptosis, Curr. Opin. Genet. Dev, vol.5, pp.97-104, 1995. ,
Apoptosis: the role of the endonu clease, Am. ¡. Pathol, vol.136, pp.593-608, 1990. ,
Cell death: the significance of apoptosis, Int. Rev. Cytol, vol.68, pp.251-306, 1980. ,
,
,
Characterization of the endogenous deoxyribonuclease in volved in nuclear DNA degradation during apoptosis ,
, EMBO J, vol.12, pp.371-377, 1993.
Identification, purification, and characterization of a calcium dependent endonuclease (NUC 18) from apoptotic rat thymocytes. NUC18 is not histone H2B, J. Biol. Chem, vol.266, pp.18580-18585, 1991. ,
Ca-+/Mg~*-dependent endonuclease from human spleen: purification, properties, and role in apopiosis, Arch. Biochem. Biophys, vol.300, pp.9129-9136, 1993. ,
An inducible lymphocyte nuclear Ca2*/Mg2*-dependent endonuclease associated with apopiosis, Biochemistry, vol.756, pp.711-720, 1996. ,
,
Purification and properties of DNase -y from apoptolic rat thymocytes, Biochem. J, vol.326, pp.675-681, 1997. ,
,
,
,
,
, Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2* concentration, Arch. Biochem. Biophys, vol.269, pp.365-370, 1989.
,
3,7,8-Tetrachlorodibenzo-/7-dioxin kills immature thymocytes by Ca2 +-mediated endonuclease activation, Orrenius. S, vol.2, pp.256-259, 1988. ,
,
,
,
Elevations in cytosolic free Ca2 + are not required to trigger apoptosis in human leukaemia cells, Clin. Exp. Immunol, vol.87, pp.465-471, 1992. ,
,
Etoposide-induced apopiosis in human HL-60 cells is associated with intracellular acidification, Cancer Res, vol.53, pp.2349-2357, 1993. ,
,
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE, Nature (Lond.), vol.371, pp.346-347, 1994. ,
,
,
,
,
,
,
Identification and inhibition of ICE/CED-3 protease necessary for mammalian apopiosis, Nature (Lond.), .», vol.76, pp.37-43, 1995. ,
Cell-free reconstitution of Fas-, UV radiation-and ceramide-induced apoptosis, EMBO J, vol.14, pp.5191-5200, 1995. ,
,
Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways, EMBO J, vol.15, pp.5504-5512, 1996. ,
,
A caspase-activated DNase that degrades DNA during apoptosis. and its inhibitor ICAD, Nature (Lond.), vol.391, pp.43-50, 1998. ,
The role of proteases during apoptosis, FASEB J, vol.10, pp.587-597, 1996. ,
Protease activation during apopiosis: dealh by a thousand cuts, Cell, vol.82, pp.349-352, 1995. ,
Induction of endonucleolytic DNA cleavage in human acute my elogenous leukemia cells by etoposide. camptothecin, and other cytotoxic anlicancer drugs: a caulionary note, Cancer Res, vol.49, pp.5870-5878, 1989. ,
Differential induclion of secondary fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression, Cancer Res, vol.51, pp.6280-6285, 1991. ,
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA lopoisomera.se I and II inhibitors, Blood, vol.81, pp.1359-1368, 1993. ,
,
Induction of apoptosis (programmed cell death) in human leukcmic HL-60 cells by inhibition of RNA or protein synthesis, Exp. Cell Res, vol.145, pp.388-397, 1990. ,
,
Androgen ablation leads to an upregulation and intranuclear accumulation of deoxyri bonuclease I in ral proslale epithelial cells paralleling their apoptotic elimination, J. Cell Biol, vol.137, pp.909-923, 1997. ,
Purification of DNA from formal dehyde fixed and paraffin embedded human tissue, Biochem. Biophys. Res. Com mun, vol.130, pp.118-126, 1985. ,
,
Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 Icukemic cells and normal thymocytes, Leukemia (Baltimore), vol.6, pp.1113-1120, 1992. ,
Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis, Cancer Res, vol.53, pp.3976-3985, 1993. ,
,
Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation, J. Exp. Med, pp.2113-2123, 1994. ,
,
Involvement of multiple proteases during Fas-medialed apoptosis in T lympho cytes, FEES Lett, vol.364, pp.134-138, 1995. ,
,
Serine protease inhibitors block neutralsphingomyelinase activation, ceramide generation, and apop tosis triggered by daunorubicin, pp.695-702, 1997. ,
,
,
Processing/ activation of at least four intcrleukin-1/3 converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells, J. Cell Biol, vol.137, pp.469-479, 1997. ,
Actin is the naturally occurring inhibitor of deoxyribonuclease I, Proc. Nati. Acad. Sci. USA, vol.71, pp.4742-4746, 1974. ,
,
Identification of programmed cell death in .V/'/M via specific labeling of nuclear DNA fragmentation, J. Cell Biol, vol.119, pp.493-501, 1992. ,
,
DNA fragmentation during apoptosis is caused by frequent single-strand cuts, Nucleic Acids Res, vol.21, pp.4206-4209, 1993. ,
,
Evidence that DNA fragmentation in apoptosis is initiated and propagated by single-strand breaks, Cell Death Differ, vol.4, pp.506-515, 1997. ,
,
A primary role for K* and Na* efflux in the activation of apoptosis, J. Biol. Chem, vol.272, pp.32436-32442, 1997. ,
Intracellular K* suppresses the activation of apoptosis in lymphocytes, J. Biol. Chem, vol.272, pp.30567-30576, 1997. ,
Deoxyribonuclease I in mammalian tissues. Specificity of inhibition by actin, J. Biol. Chem, vol.256, pp.2644-2648, 1981. ,
,
Purification and properties of an endodeoxyribonuclease from nuclei of bovine small intestinal mucosa, J. Biol. Chem, vol.256, pp.1636-1642, 1981. ,
,
An endodeoxyribonuclease of human KB cells. Purification and properties of the enzyme, J. Biol. Chem, vol.253, pp.3400-3407, 1978. ,
,
Purification and properties of a magnesiumdependent endodeoxyribonuclease endogenous to rat-liver nuclei, Biochim. Biophys. Acta, vol.950, pp.313-320, 1988. ,
Mechanism of action and structure of acid deoxyribonuclease, Adv. Enzymol, vol.31, pp.1-7, 1968. ,
Intracellular acidification is associated with, but not required for caspase activation. DNA fragmentation or apoptosis, Int. J. Oncol, pp.1241-1246, 1997. ,
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis, Nature (Lond.), vol.391, pp.96-99, 1998. ,