A general mechanism for microsomal activation of quinone anticancer agents to free radicals, Cancer Res, vol.38, pp.1745-1750, 1978. ,
Free radicals in anticancer drug pharmacology, Chem. Biol. Int, vol.69, pp.293-317, 1989. ,
The measurement and mechanism of lipid peroxidation in biological systems, Trends Biochem. Sci, vol.15, pp.129-135, 1990. ,
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response, Science, 1977. ,
The role of lipid peroxidation in acute doxorubicin-induced cardiotoxicity as studied in rat isolated heart, J. Pharm. Pharmacol, vol.38, pp.277-282, 1986. ,
Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects, Biochem. Pharmacol, vol.31, pp.575-581, 1982. ,
Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones, Proc. Narl Acad. Sci. USA, vol.83, pp.4514-4518, 1986. ,
Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance, Cancer Res, vol.49, pp.3844-3848, 1989. ,
Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity, Cancer Res, vol.47, 1987. ,
DNA topoisomerases as targets for chemotherapy, FASEB J, vol.2, pp.2474-2478, 1988. ,
Mechanism of multidrug resistance, Biochim. Biophys. Acta, vol.948, pp.87-128, 1988. ,
Multiple-drug resistance in human cancer, N. Eng. J. Med, vol.316, pp.1388-1393, 1987. ,
Genetics of multidrug resistance, J. Clin. Invest, vol.81, pp.1303-1309, 1988. ,
Pharmacological, molecular and cytogenetic analysis of atypical multidrug-resistant human leukemic cells, Cancer Res. 47, 36. Doroshow, Biochem. Biophys. Res. Commun, vol.135, pp.330-335, 1986. ,
Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells, Cancer Res, vol.49, pp.511-515, 1989. ,
, , vol.197, pp.165-167, 1986.
, glutathione transferase in multidrug-resistant human breast cancer cells, J. Biol. Chem, vol.261, pp.544-559
Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and g1utathione-Stransferase-n, Mol. Pharmacol, vol.37, pp.801-809, 1990. ,
Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content, Free Radical Res. Commun, p.12, 1991. ,
990) Antioxidant and xenobiotic-metabolizing enzyme gene expression in doxorubicin-resistant MCF-7 breast cancer cells, Cancer Res, vol.50, issue.1, pp.1397-1402 ,
Increased glutathione peroxidase activity in a human sarcoma cell line with inherent doxorubicin resistance, Cancer Res, vol.51, pp.521-527, 1991. ,
The glutathione S-transferases: an update, Hepatology, vol.9, pp.486-496, 1989. ,
Development of mechanisms of protection against oxidative stress in doxorubicin-resistant rat tumoral cells in culture, Free Radical Res. Commun, vol.11, pp.137-144, 1990. ,
Measurement of doxorubicin-induced lipid peoxidation in the conditions that determine cytotoxicity in cultured tumor cells, Anal. Biochem, 1992. ,
Induction of tyrosine a-ketoglutarate transaminase by steroid hormons in a newly established tissue culture cell line, Proc. Nut1 Acad. Sci. USA, vol.161, pp.293-303, 1966. ,
On the resistance of cultured cells to doxorubicin, Stud. Biuphys, vol.104, pp.326-330, 1984. ,
, logical and molecular characterization of three rodent cell lines in culture selected for resistance to doxorubicin, Anticancer Drugs, pp.245-252
Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells, Cancer Res, vol.47, pp.5141-5148, 1987. ,
Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct, Clin. Chem, vol.33, pp.214-220, 1987. ,
Species, tissue and subcellular distribution of non Se-dependent glutathione peroxidase activity, J. Nutr, vol.108, pp.211-215, 1978. ,
Expression of glutathione peroxidase I gene in selenium-deficient rats, Nucleic Acids Res, vol.16, pp.5557-5568, 1988. ,
Molecular cloning: a laboratory manual, 1989. ,
987) Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells, Biochem. Pharmacol, vol.36, pp.793-796 ,
Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action, Biochemistry, vol.26, pp.3776-3781, 1987. ,
Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour, Biochem J, vol.250, pp.247-252, 1988. ,
Free radicals and anticancer drug resistance: oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors, Free Radical Biol. Med, vol.8, pp.567-581, 1990. ,