Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus, Hepatology, vol.47, pp.1856-62, 2008. ,
Natural history of hepatitis C, J Hepatol, vol.61, issue.14, pp.481-485, 2014. ,
Global distribution and prevalence of hepatitis C virus genotypes, Hepatology, vol.61, pp.77-87, 2015. ,
The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis, BMC Infect Dis, vol.13, 2013. ,
Hepatitis C virus: A global view, World J Hepatol, vol.7, pp.2676-80, 2015. ,
The hidden epidemic of hepatitis C virus infection in the United States: occult transmission and burden of disease, Top Antivir Med, vol.21, pp.15-24, 2013. ,
Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus, J Virol, vol.82, pp.966-973, 2008. ,
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor, J Biol Chem, vol.278, 2003. ,
The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity, J Gen Virol, vol.92, pp.112-121, 2011. ,
Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma, Proc Natl Acad Sci U S A, vol.104, pp.8449-8454, 2007. ,
Neutralizing activities of caprine antibodies towards conserved regions of the HCV envelope glycoprotein E2, Virol J, vol.8, p.391, 2011. ,
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge, Nat Med, vol.14, pp.25-27, 2008. ,
Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes, J Immunol, vol.175, pp.3603-3613, 2005. ,
HCV persistence and immune evasion in the absence of memory T cell help, Science, vol.302, pp.659-662, 2003. ,
Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection, J Exp Med, vol.197, pp.1645-1655, 2003. ,
CD8(+) T-cell responses in acute Hepatitis C virus infection, Front Immunol, vol.5, p.266, 2014. ,
The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection, J Hepatol, vol.38, pp.349-356, 2003. ,
Progress in the development of preventive and therapeutic vaccines for hepatitis C virus, J Hepatol, vol.54, issue.11, pp.18-21, 2011. ,
A new insight into hepatitis C vaccine development, J Biomed Biotechnol, p.548280, 2010. ,
Cationic microparticles are a potent delivery system for a HCV DNA vaccine, Vaccine, vol.23, pp.672-680, 2004. ,
Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins, Vaccine, vol.25, issue.06, pp.1171-1177, 2007. ,
Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers, Hum Vaccin, vol.5, pp.151-157, 2009. ,
Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects, Vaccine, vol.24, issue.06, pp.273-281, 2006. ,
Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different human leukocyte antigen-class I-A alleles, Cancer Sci, vol.100, 1935. ,
Mice antibody response to conserved Nonadjuvanted multiple antigenic peptides derived from E1/E2 regions of Hepatitis C virus ,
Immunogenicity of CIGB-230, a therapeutic DNA vaccine preparation, in HCV-chronically infected individuals in a Phase I clinical trial, J Viral Hepat, vol.16, pp.156-167, 2009. ,
Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver, Hum Vaccin, vol.7, pp.1326-1335, 2011. ,
Strong HCV NS3-and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine, Vaccine, vol.26, pp.954-961, 2008. ,
Advances in DNA immunization against hepatitis C virus infection, Hum Vaccin, vol.5, pp.568-571, 2009. ,
A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C, Gastroenterology, vol.141, issue.11, pp.766-775, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00827965
Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells, Hepatology, vol.54, pp.28-37, 2011. ,
Monocytes transduced with lentiviral vectors expressing hepatitis C virus non-structural proteins and differentiated into dendritic cells stimulate multi-antigenic CD8(+) T cell responses, Vaccine, vol.28, pp.922-933, 2010. ,
CD4+ immune escape and subsequent T-cell failure following chimpanzee immunization against hepatitis C virus, Hepatology, vol.44, pp.736-781, 2006. ,
Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes, Semin Liver Dis, vol.15, pp.41-63, 1995. ,
Sequence variability in the 5? non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity, J Gen Virol, vol.74, pp.661-669, 1993. ,
,
Phylogenetic and Genotyping of Hepatitis C Virus in Egypt ,
, Australian J of Basic and Applied Sciences, vol.3, pp.1-8, 2009.
Optimal therapy in genotype 4 chronic hepatitis C: finally cured?, Liver Int, vol.35, issue.1, pp.27-34, 2015. ,
Los alamos hepatitis C immunology database, Appl Bioinformatics, vol.4, pp.217-225, 2005. ,
Immunogenicity of multi-epitope DNA and peptide vaccine candidates based on Core, E2, NS3 and NS5B HCV epitopes in BALB/c mice, Hepat Mon, vol.14, p.22215, 2014. ,
Cellular immunogenicity of a multi-epitope peptide vaccine candidate based on hepatitis C virus NS5A, NS4B and core proteins in HHD-2 mice, J Virol Methods, vol.189, issue.13, pp.8-14, 2013. ,
Review of the medical research ethics committee (MREC), Curr Med Res Opin, vol.29, pp.1411-1418, 2003. ,
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome, Nat Med, vol.11, pp.791-796, 2005. ,
Robust production of infectious viral particles in Huh-7 cells by introducing mutations in hepatitis C virus structural proteins, J Gen Virol, vol.88, pp.2495-2503, 2007. ,
Identification of GBF1 as a cellular factor required for hepatitis C virus RNA replication, J Virol, vol.84, pp.773-787, 2010. ,
Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization, Proc Natl Acad Sci U S A, vol.105, pp.997-1002, 2008. ,
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate, PLoS Pathog, vol.8, p.1002653, 2012. ,
Growth of human hepatoma cells lines with differentiated functions in chemically defined medium, Cancer Res, vol.42, pp.3858-63, 1982. ,
Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses, J Virol, vol.68, pp.6147-60, 1994. ,
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection, Lancet, vol.346, issue.95, pp.91691-91692, 1995. ,
Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C, Gastroenterology, vol.117, pp.933-941, 1999. ,
Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C, Hepatology, vol.37, pp.1189-1198, 2003. ,
T-cell responses in hepatitis B and C virus infection: similarities and differences, Emerg Microbes Infect, vol.2, 2013. ,
Virus-neutralizing antibodies to hepatitis C virus, J Viral Hepat, vol.20, pp.369-76, 2013. ,
Experimental vaccine activities of recombinant E1 and E2 glycoproteins and hypervariable region 1 peptides of hepatitis C virus in chimpanzees, Arch Virol, vol.144, pp.973-80, 1999. ,
The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in Guinea pigs, Hepatology, vol.65, pp.1117-1148, 2017. ,
Broadly cross-reactive, high-affinity antibody to hypervariable region 1 of the hepatitis C virus in rabbits, Virology, vol.258, issue.99, pp.99730-99731, 1999. ,
A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization Resistance, J Virol, vol.90, pp.3288-301, 2015. ,
,
Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees, PLoS Pathog, vol.8, p.1002895, 2012. ,
Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus, J Infect Dis, vol.204, pp.1186-1190, 2011. ,
Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice, J Virol, vol.90, pp.10486-10498, 2016. ,
C vaccines, antibodies, and T cells, Front Immunol, vol.9, p.1480, 2018. ,
Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults, Vaccine, vol.28, issue.10, pp.925-929, 2010. ,
The Humoral immune response to HCV: understanding is key to vaccine development, Front Immunol, vol.5, p.550, 2014. ,
Hepatitis C virus NS5A protein interacts with 2?,5?-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner, J Gen Virol, vol.85, pp.959-69, 2004. ,
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response, J Virol, vol.75, pp.6095-106, 2001. ,
Hepatitis C virus nonstructural protein 5A modulates the tolllike receptor-MyD88-dependent signaling pathway in macrophage cell lines, J Virol, vol.81, pp.649-656, 2007. ,
Transcriptional Dysregulation of Upstream Signaling of IFN Pathway in Chronic HCV Type 4 Induced Liver Fibrosis, PLoS One, vol.11, p.154512, 2016. ,
Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees, J Virol, vol.78, pp.13779-13792, 2004. ,
Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C, Liver Int, vol.26, pp.1100-1110, 2006. ,
Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C, J Infect Dis, vol.181, pp.1528-1536, 2000. ,
Virus-specific CD8+ lymphocytes share the same effectormemory phenotype but exhibit functional differences in acute hepatitis B and C, J Virol, vol.76, pp.12423-12457, 2002. ,
Impaired effector function of hepatitis C virusspecific CD8+ T cells in chronic hepatitis C virus infection, J Immunol, vol.169, pp.3447-58, 2002. ,
Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees, Hepatology, vol.39, pp.1709-1729, 2004. ,
Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice, J Virol, vol.83, pp.8463-8469, 2009. ,
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs, Hepatology, vol.35, pp.694-703, 2002. ,
, Publisher's Note
, Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations