Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2017

Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis

Laurent Auboire
Damien Fouan
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Frédéric Ossant
  • Fonction : Auteur
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  • IdRef : 148633196
Jean-Marc Grégoire
Ayache Bouakaz

Résumé

Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measuring clot dissolution is essential. This study aimed to evaluate and validate high resolution ultrasound as a tool to assess the exact volume of clots in 3D and in real time during in vitro thrombolytic drug testing. This new method was validated by measuring the effects of concentration range of recombinant tissue type plasminogen activator on a blood clot during complete occlusion or 70% stenosis of a vessel. This study shows that high resolution ultrasound imaging allows for a real-time assessment of the 3D volume of a blood clot with negligible inter- and intra-operator variabilities. The conclusions drawn from this study demonstrate the promising potential of high resolution ultrasound imaging for the in vitro assessment of new thrombolytic drugs.
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Dates et versions

inserm-02438161 , version 1 (28-12-2023)

Identifiants

Citer

Laurent Auboire, Jean-Michel Escoffre, Damien Fouan, Jean-René Jacquet, Frédéric Ossant, et al.. Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis. Scientific Reports, 2017, 7 (1), pp.6211. ⟨10.1038/s41598-017-06089-z⟩. ⟨inserm-02438161⟩
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