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Association between a pro plant-based dietary score and cancer risk in the prospective NutriNet-santé cohort

Abou Kane-Diallo 1 Bernard Srour 1 Laury Sellem 1 Mélanie Deschasaux 1 Paule Latino-Martel 1 Serge Hercberg 1 Pilar Galan 1 Philippine Fassier 1 Françoise Guéraud 2 Fabrice H.F. Pierre 2 Emmanuelle Kesse-Guyot 1 Benjamin Alles 1 Mathilde Touvier 1 
1 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
UP13 - Université Paris 13, INRA - Institut National de la Recherche Agronomique : UMR1125, CNAM - Conservatoire National des Arts et Métiers [CNAM], CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
Abstract : Diverse plant products (e.g. fruits, vegetables, legumes) are associated with decreased cancer risk at several locations while red and processed meat were found to increase cancer risk. A pro plant-based dietary score reflecting the relative contribution of consumed plant vs animal products was developed, and was associated with lower overall mortality, type 2 diabetes and cardiovascular disease risk, among omnivorous adults. For the first time, we investigated the prospective associations between this pro plant-based dietary score and cancer risk. This study included 42,544 men and women of the French NutriNet-Santé prospective cohort (2009-2016) aged ≥45 years who completed at least three 24-hr-dietary records during the first year of follow-up. The risk of developing cancer was compared across sex-specific tertiles of pro plant-based dietary score by multivariable Cox models. In total, 1,591 first primary incident cancer cases were diagnosed during follow-up, among which 487 breast, 243 prostate, 198 digestive and 68 lung cancers. A higher pro plant-based dietary score was associated with decreased risks of overall (HRt3vs.t1 =0.85; 95% CI 0.76, 0.97; Ptrend =0.02), digestive (HRt3vs.t1 =0.68; 95% CI 0.47; 0.99; Ptrend  = 0.04) and lung (HRt3vs.t1 =0.47; 95% CI 0.25, 0.90; Ptrend =0.02) cancer, though no substantial associations were found for breast or prostate cancers. This large cohort study supports a beneficial role of higher intakes of plant-based products along with lower intakes of animal products, within a balanced omnivorous diet, regarding primary cancer prevention. These results are consistent with mechanistic evidence from experimental studies.
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Submitted on : Tuesday, January 14, 2020 - 9:49:17 AM
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Abou Kane-Diallo, Bernard Srour, Laury Sellem, Mélanie Deschasaux, Paule Latino-Martel, et al.. Association between a pro plant-based dietary score and cancer risk in the prospective NutriNet-santé cohort. International Journal of Cancer, Wiley, 2018, 143 (9), pp.2168-2176. ⟨10.1002/ijc.31593⟩. ⟨inserm-02438095⟩



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