A. Abrahao, Y. Meng, M. Llinas, Y. Huang, C. Hamani et al.,

H. K. Se, N. Lipsman, and L. Zinman, Motor Cortex Blood-Brain Barrier Opening in 1254

, Amyotrophic Lateral Sclerosis using MR-Guided Focused Ultrasound: A First-in-Human

, Trial. Nat Commun, vol.10, p.4373, 2019.

C. N. Acconcia, R. M. Jones, D. E. Goertz, M. A. O'reilly, and K. Hynynen, Megahertz rate, volumetric 1257 imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver 1258 array, Phys Med Biol, vol.62, pp.31-40, 2017.

C. N. Acconcia, B. Y. Leung, and D. E. Goertz, The microscale evolution of the erosion front of blood 1260 clots exposed to ultrasound stimulated microbubbles, J Acoust Soc Am, vol.139, p.135, 2016.

A. Agarwal, J. Ng, W. Liu, and Y. , Removal of biofilms by intermittent low-intensity 1262 ultrasonication triggered bursting of microbubbles, Biofouling, vol.30, pp.359-65, 2014.

A. V. Alexandrov, A. M. Demchuk, W. S. Burgin, D. J. Robinson, J. C. Grotta et al.,

, Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the 1265 CLOTBUST trial, J Neuroimaging, vol.14, pp.113-120, 2004.

A. V. Alexandrov, A. W. Wojner, J. C. Grotta, and C. Investigators, CLOTBUST: design of a randomized 1267 trial of ultrasound-enhanced thrombolysis for acute ischemic stroke, J Neuroimaging, vol.1268, pp.108-120, 2004.

R. Alkins, A. Burgess, M. Ganguly, G. Francia, R. Kerbel et al., Focused 1270 ultrasound delivers targeted immune cells to metastatic brain tumors, Cancer Res, vol.1271, pp.1892-1901, 2013.

R. Alkins, A. Burgess, R. Kerbel, W. S. Wels, and K. Hynynen, Early treatment of HER2-amplified 1273 brain tumors with targeted NK-92 cells and focused ultrasound improves survival, Endocrinology, vol.18, pp.1492-505, 1274.

K. B. Bader, M. J. Gruber, and C. K. Holland, Shaken and stirred: mechanisms of ultrasound-enhanced 1302 thrombolysis, Ultrasound Med Biol, vol.41, pp.187-96, 2015.

K. B. Bader, K. J. Haworth, H. Shekhar, A. D. Maxwell, T. Peng et al.,

, Efficacy of histotripsy combined with rt-PA in vitro, Phys Med Biol, vol.61, pp.5253-74, 2016.

K. B. Bader and C. K. Holland, Gauging the likelihood of stable cavitation from ultrasound contrast 1306 agents, Phys Med Biol, vol.58, pp.127-171, 2013.

K. B. Bader, E. Vlaisavljevich, and A. D. Maxwell, For Whom the Bubble Grows: Physical Principles 1308 of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy, Ultrasound Med, vol.45, pp.1056-80, 1309.

Y. J. Bae, Y. I. Yoon, T. J. Yoon, and H. J. Lee, Ultrasound-Guided Delivery of siRNA and a 1311

, Chemotherapeutic Drug by Using Microbubble Complexes: In Vitro and In Vivo 1312 Evaluations in a Prostate Cancer Model, Korean J Radiol, vol.17, pp.497-508, 2016.

S. Bao, B. D. Thrall, and D. L. Miller, Transfection of a reporter plasmid into cultured cells by 1314 sonoporation in vitro, Ultrasound Med Biol, vol.23, pp.953-59, 1997.

Y. Barenholz, Doxil (R) -The first FDA-approved nano-drug: Lessons learned, J Control, vol.160, pp.117-151, 1316.

I. Beekers, T. Van-rooij, M. D. Verweij, M. Versluis, N. De-jong et al., Acoustic 1318 Characterization of a Vessel

, Drug Delivery, IEEE Trans Ultrason Ferroelectr Freq Control, vol.65, pp.570-81, 2018.

E. Beguin, S. Shrivastava, N. V. Dezhkunov, A. P. Mchale, J. F. Callan et al., , p.1321

, Multibubble Sonoluminescence Using Therapeutic Ultrasound and Microbubbles

, opens the blood-brain barrier and improves pathologic abnormalities and behavior, Appl Mater Interfaces, vol.11, pp.736-781, 1349.

A. Burgess, Y. X. Huang, A. C. Waspe, M. Ganguly, D. E. Goertz et al.,

, Focused Ultrasound (HIFU) for Dissolution of Clots in a Rabbit Model of Embolic 1352

, Stroke. PLoS One, vol.7, 2012.

M. T. Burgess and T. M. Porter, Control of Acoustic Cavitation for Efficient Sonoporation with Phase

, Shift Nanoemulsions, Ultrasound Med Biol, vol.45, pp.846-58, 2019.

C. W. Burke, A. E. Timbie, K. Kilbanov, A. L. Price, and R. J. , Ultrasound-activated Agents 1356 Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor 1357 Growth and Improve Survival, Mol Ther, vol.22, pp.321-349, 2014.

B. Campbell, P. J. Mitchell, L. Churilov, N. Yassi, T. J. Kleinig et al., , p.1359

H. M. Dewey, V. Thijs, R. Scroop, M. Simpson, M. Brooks et al., , p.1360

T. Wijeratne, T. Ang, F. Miteff, C. R. Levi, E. Rodrigues et al.,

C. , B. P. Rice, H. De-villiers, L. Brown, H. Redmond et al.,

W. Wong, A. A. Muller, C. Coulthard, A. Mitchell, K. Clouston et al.,

H. Phan, T. G. Chong, W. Chandra, R. V. Slater, L. A. Krause et al., , p.1364

B. S. Steinfort, C. F. Bladin, G. Sharma, P. M. Desmond, M. W. Parsons et al., Davis 1365 SM, Investigators E-IT. Tenecteplase versus Alteplase before Thrombectomy for, p.1366

, Ischemic Stroke, New Engl J Med, vol.378, pp.1573-82, 2018.

W. J. Cao, J. D. Rosenblat, N. C. Roth, M. A. Kuliszewski, P. N. Matkar et al., , p.1368

H. Leong-poi, Therapeutic Angiogenesis by Ultrasound-Mediated MicroRNA-126-3p

. Delivery, Arterioscler Thromb Vasc Biol, vol.35, pp.2401-2412, 2015.

Y. Cao, Y. Chen, T. Yu, Y. Guo, F. Liu et al., Drug 1371 Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused

, Ultrasound. Theranostics, vol.8, pp.1327-1366, 2018.

A. Carpentier, M. Canney, A. Vignot, V. Reina, K. Beccaria et al.,

D. , L. C. Chapelon, J. Y. Capelle, L. Cornu, P. Sanson et al., , p.1375

A. Idbaih, Clinical trial of blood-brain barrier disruption by pulsed ultrasound, Sci Transl 1376 Med, vol.8, pp.343-345, 2016.

E. L. Carstensen and H. G. Flynn, The Potential for Transient Cavitation with Microsecond Pulses of

, Ultrasound, Ultrasound Med Biol, vol.8, pp.720-744, 1982.

C. F. Caskey, S. Qin, P. A. Dayton, and K. W. Ferrara, Microbubble tunneling in gel phantoms, J Acoust, p.1380

, Soc Am, vol.125, pp.183-192, 2009.

H. Chen, A. A. Brayman, W. Kreider, M. R. Bailey, and T. J. Matula, Observations of translation and 1382 jetting of ultrasound-activated microbubbles in mesenteric microvessels, 1383.

, Med Biol, vol.37, pp.2139-2187, 2011.

P. Y. Chen, H. L. Liu, M. Y. Hua, H. W. Yang, C. Y. Huang et al., , p.1385

H. C. Tsai, S. M. Chen, Y. J. Lu, J. J. Wang, T. C. Yen et al., Novel magnetic/ultrasound focusing system enhances 1387 nanoparticle drug delivery for glioma treatment, Neuro Oncol, vol.12, pp.1050-60, 2010.

S. Chen, J. Chen, P. Huang, X. L. Meng, S. Clayton et al., Myocardial 1389 regeneration in adriamycin cardiomyopathy by nuclear expression of GLP1 using 1390 ultrasound targeted microbubble destruction, Biochem Biophys Res Commun, vol.1391, pp.823-832, 2015.

S. Chen, J. Chen, X. L. Meng, J. S. Shen, J. Huang et al.,

, ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac 1394 progenitor cells, Oncotarget, vol.7, pp.80391-403, 2016.

X. Chen, R. S. Leow, Y. Hu, J. M. Wan, and A. C. Yu, Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant 1423 for uptake via membrane pores or endocytosis, Journal of the Royal Society Interface, vol.11, pp.20-28, 2014.

D. Victor, M. D. Barnsley, L. C. Carugo, D. Owen, J. Coussios et al.,

, Sonothrombolysis with Magnetically Targeted Microbubbles, Ultrasound Med Biol, vol.45, pp.1151-63, 1426.

T. Deffieux, G. Montaldo, M. Tanter, and M. Fink, Shear wave spectroscopy for in vivo quantification 1428 of human soft tissues visco-elasticity, IEEE Trans Med Imaging, vol.28, pp.313-335, 2009.

®. Definity, US Food and Drug Administration, 2011.

J. Deng, Q. Huang, F. Wang, Y. Liu, Z. Wang et al., The role of caveolin-1 1431 in blood-brain barrier disruption induced by focused ultrasound combined with 1432 microbubbles, J Mol Neurosci, vol.46, pp.677-87, 2012.

L. Deng, M. A. O'reilly, R. M. Jones, R. An, and K. Hynynen, A multi-frequency sparse hemispherical 1434 ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous 1435 cavitation mapping, Phys Med Biol, vol.61, pp.8476-501, 2016.

Q. Deng, B. Hu, S. Cao, H. N. Song, J. L. Chen et al., Improving the efficacy of therapeutic 1437 angiogenesis by UTMD-mediated Ang-1 gene delivery to the infarcted myocardium

, J Mol Med, vol.36, pp.335-379, 2015.

H. Dewitte, S. Van-lint, C. Heirman, K. Thielemans, D. Smedt et al.,

, The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for 1441 ultrasound-triggered cancer immunotherapy, J Control Release, vol.194, pp.28-36, 2014.

H. Dewitte, K. Vanderperren, H. Haers, E. Stock, L. Duchateau et al., , 1443.

L. I. Sc and S. C. De, Theranostic mRNA-loaded Microbubbles in the Lymphatics of activity of cells exposed to ultrasound in the presence of contrast agents, J Acoust Soc, vol.131, pp.2723-2732, 1518.

Y. Y. Fu, L. Zhang, Y. Yang, C. W. Liu, Y. N. He et al., Synergistic antibacterial effect of 1520 ultrasound microbubbles combined with chitosan-modified polymyxin B-loaded 1521 liposomes on biofilm-producing Acinetobacter baumannii, Int J Nanomedicine, vol.1522, pp.1805-1820, 2019.

D. A. Gabriel, K. Muga, and E. M. Boothroyd, The Effect of Fibrin Structure on Fibrinolysis, J Biol, vol.267, pp.24259-63, 1524.

M. J. Garcia, Endovascular Management of Acute Pulmonary Embolism Using the Ultrasound-1526

, Enhanced EkoSonic System. Seminars in Interventional Radiology, vol.32, pp.384-87, 2015.

M. Gauberti, Reperfusion in acute ischaemic stroke by sonothrombolysis, Lancet Neurol, vol.1528, pp.320-341, 2019.

D. E. Goertz, An overview of the influence of therapeutic ultrasound exposures on the 1530 vasculature: high intensity ultrasound and microbubble-mediated bioeffects, Int J 1531 Hyperthermia, vol.31, pp.134-178, 2015.

B. Goh, M. Conneely, H. Kneupner, T. Palmer, E. Klaseboer et al., , 2015.

, High-speed imaging of ultrasound-mediated bacterial biofilm disruption. 6th European 1534 Conference of the International Federation for Medical and Biological Engineering: 1535 Sprinter International Publishing, pp.533-569

S. Goutal, M. Gerstenmayer, S. Auvity, F. Caillé, S. Mériaux et al.,

, Physical blood-brain barrier disruption induced by focused ultrasound does not overcome 1538 the transporter-mediated efflux of erlotinib, J Control Release, vol.292, pp.210-230, 2018.

A. Goyal, F. Yu, M. G. Tenwalde, X. C. Chen, A. Althouse et al.,

S. M. Graham, R. Carlisle, J. J. Choi, M. Stevenson, A. R. Shah et al., , p.1544

L. Seymour and C. C. Coussios, Inertial cavitation to non-invasively trigger and monitor 1545 intratumoral release of drug from intravenously delivered liposomes, J Control Release, vol.1546, pp.101-108, 2014.

G. Navarro, A. Bjorklund, A. T. Chekenya, and M. , Therapeutic potential and challenges of natural 1548 killer cells in treatment of solid tumors, Front Immunol, vol.6, p.202, 2015.

H. Guo, Z. Wang, Q. Du, P. Li, Z. Wang et al., Stimulated phase-shift acoustic nanodroplets 1550 enhance vancomycin efficacy against methicillin-resistant Staphylococcus aureus 1551 biofilms, Int J Nanomed, vol.12, pp.4679-90, 2017.

X. Guo, C. Cai, G. Xu, Y. Yang, J. Tu et al., Interaction between cavitation 1553 microbubble and cell: A simulation of sonoporation using boundary element method 1554 (BEM), Ultrason Sonochem, vol.39, pp.863-71, 2017.

R. Gupta, J. Shea, C. Scafe, A. Shurlygina, and N. Rapoport, Polymeric micelles and nanoemulsions 1556 as drug carriers: Therapeutic efficacy, toxicity, and drug resistance, J Control Release, vol.1557, pp.70-77, 2015.

M. Gyöngy and C. C. Coussios, Passive cavitation mapping for localization and tracking of bubble 1559 dynamics, J Acoust Soc Am, vol.128, pp.175-80, 2010.

M. F. Hamilton, D. T. Blackstock, . Nonlinear, and . Melville, , 1561.

Y. W. Han, A. Ikegami, P. Chung, L. Zhang, and C. X. Deng, Sonoporation is an efficient tool for 1563 intracellular fluorescent dextran delivery and one-step double-crossover mutant 1564 construction in Fusobacterium nucleatum, Appl Environ Microbiol, vol.73, pp.3677-83, 2007.

, Heterogeneously Sonoporated Cells by Microbubbles with Single-Pulse Ultrasound

, Ultrasound Med Biol, vol.44, pp.1074-85, 2018.

R. M. Jones, L. Deng, K. Leung, D. Mcmahon, M. A. O'reilly et al., Three-dimensional 1616 transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-1617 brain barrier opening, Theranostics, vol.8, pp.2909-2935, 2018.

R. M. Jones, M. A. O'reilly, and K. Hynynen, Transcranial passive acoustic mapping with 1619 hemispherical sparse arrays using CT-based skull-specific aberration corrections: a 1620 simulation study, Phys Med Biol, vol.58, pp.4981-5005, 2013.

R. M. Jones, M. A. O'reilly, and K. Hynynen, Experimental demonstration of passive acoustic imaging 1622 in the human skull cavity using CT-based aberration corrections, Med Phys, vol.1623, pp.4385-400, 2015.

J. F. Jordão, E. Thévenot, K. Markham-coultes, T. Scarcelli, Y. Q. Weng et al., , p.1625

Y. Huang, J. Mclaurin, K. Hynynen, and A. I. , Amyloid-? plaque reduction, endogenous 1626 antibody delivery and glial activation by brain-targeted

, Exp Neurol, vol.248, pp.16-29, 2013.

E. K. Juang, D. Cock, I. Keravnou, C. Gallagher, M. K. Keller et al.,

, Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble

, Mediated Drug Delivery, Langmuir, vol.35, pp.10128-10166, 2019.

M. R. Junttila and F. J. De-sauvage, Influence of tumour micro-environment heterogeneity on 1632 therapeutic response, Nature, vol.501, pp.346-54, 2013.

H. A. Kamimura, J. Flament, J. Valette, A. Cafarelli, A. Badin et al.,

, Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier 1635 disruption in non-human primates under magnetic resonance guidance, J Cereb Blood, p.1636

, Flow Metab, vol.39, pp.1191-203, 2019.

B. P. Mead, P. Mastorakos, J. S. Suk, A. L. Klibanov, J. Hanes et al., Targeted gene transfer to 1810 the brain via the delivery of brain-penetrating DNA nanoparticles with focused 1811 ultrasound, J Control Release, vol.223, pp.109-126, 2016.

G. Mehta, A. Y. Hsiao, M. Ingram, G. D. Luker, and S. Takayama, Opportunities and challenges for use 1813 of tumor spheroids as models to test drug delivery and efficacy, J Control Release, vol.1814, pp.192-204, 2012.

H. S. Min, S. Son, D. G. You, T. W. Lee, J. Lee et al., , p.1816

K. Choi, K. Park, K. Kim, and I. C. Kwon, Chemical gas-generating nanoparticles for tumor-1817 targeted ultrasound imaging and ultrasound-triggered drug delivery, Biomaterials, vol.1818, pp.57-70, 2016.

C. A. Molina, M. Ribo, M. Rubiera, J. Montaner, E. Santamarina et al., Microbubble administration 1821 accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients 1822 treated with intravenous tissue plasminogen activator, Stroke, vol.37, pp.425-434, 2006.

S. Monteith, J. Sheehan, R. Medel, M. Wintermark, M. Eames et al.,

, Potential intracranial applications of magnetic resonance-guided focused ultrasound 1825 surgery, J Neurosurg, vol.118, pp.215-236, 2013.

A. S. Montero, F. Bielle, L. Goldwirt, A. Lalot, G. Bouchoux et al., , p.1827

P. F. Pradat, F. Salachas, S. Boillée, C. Lobsiger, C. Lafon et al.,

, Ultrasound-Induced Blood-Spinal Cord Barrier Opening in Rabbits, Ultrasound Med, vol.45, pp.2417-2443, 1829.

, Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability, PLoS One, vol.1832, p.159892, 2016.

R. Myers, C. Coviello, P. Erbs, J. Foloppe, C. Rowe et al., Polymeric Cups for Cavitation-mediated Delivery 1835 of Oncolytic Vaccinia Virus, Mol Ther, vol.24, pp.1627-1660, 2016.

C. F. Naudé and A. T. Ellis, On the Mechanism of Cavitation Damage by Nonhemispherical Cavities 1837

, Collapsing in Contact With a Solid Boundary, J Basic Eng, vol.83, pp.648-56, 1961.

H. Nesbitt, Y. Sheng, K. S. Logan, K. Thomas, K. Callan et al.,

D. , K. P. Beguin, E. Stride, E. Mchale, A. P. Callan et al., Gemcitabine loaded microbubbles 1840 for targeted chemo-sonodynamic therapy of pancreatic cancer, J Control Release, vol.1841, pp.8-16, 2018.

C. P. Nolsøe and T. Lorentzen, International guidelines for contrast-enhanced ultrasonography: 1843 ultrasound imaging in the new millennium, Ultrasonography, vol.35, pp.89-103, 2016.

A. N. Nowbar, M. Gitto, J. P. Howard, D. P. Francis, and R. Al-lamee,

, Disease Analysis of Data From the World Health Organization and Coronary Artery 1846

, Disease Risk Factors From NCD Risk Factor Collaboration, vol.12, 1847.

W. L. Nyborg, Acoustic Streaming near a Boundary, J Acoust Soc Am, vol.30, pp.329-368, 1958.

M. A. O'reilly, T. Chinnery, M. L. Yee, S. K. Wu, K. Hynynen et al.,

. Ki, Preliminary Investigation of Focused Ultrasound-Facilitated Drug

, Delivery for the Treatment of Leptomeningeal Metastases. Sci Rep, vol.8, p.9013, 2018.

M. A. O'reilly and K. Hynynen, Blood-brain barrier: real-time feedback-controlled focused 1853 ultrasound disruption by using an acoustic emissions-based controller, Radiology, vol.1854, pp.96-106, 2012.

M. A. O'reilly, R. M. Jones, and K. Hynynen, Three-dimensional transcranial ultrasound imaging of 1856 microbubble clouds using a sparse hemispherical array, IEEE Trans Biomed Eng, vol.1857, pp.1285-94, 2014.

T. M. Optison, US Food and Drug Administration, 2012.

V. Paefgen, D. Doleschel, and F. Kiessling, Evolution of contrast agents for ultrasound imaging and 1860 ultrasound-mediated drug delivery, Front Pharmacol, vol.6, p.197, 2015.

R. Pandit, G. Leinenga, and J. Götz, Repeated ultrasound treatment of tau transgenic mice clears 1862 neuronal tau by autophagy and improves behavioral functions, Theranostics, vol.1863, pp.3754-67, 2019.

W. M. Pardridge, The blood-brain barrier: bottleneck in brain drug development, NeuroRx, vol.1865, pp.3-14, 2005.

J. L. Paris, C. Mannaris, M. V. Cabanas, R. Carlisle, M. Manzano et al.,

, Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica 1868 nanoparticles for controlled-release drug delivery, Chem Eng J, vol.340, pp.2-8, 2018.

E. J. Park, Y. Z. Zhang, N. Vykhodtseva, and N. Mcdannold, Ultrasound-mediated blood-brain/blood-1870 tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain 1871 metastasis model, J Control Release, vol.163, pp.277-84, 2012.

Y. C. Park, C. Zhang, S. Kim, G. Mohamedi, C. Beigie et al., Jeon 1873 NL, Wong JY. Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug

. Delivery, ACS Appl Mater Interfaces, vol.8, pp.31541-31590, 2016.

A. H. Payne, G. W. Hawryluk, Y. Anzai, H. Odéen, M. A. Ostlie et al.,

S. and C. Dj, Magnetic resonance imaging-guided focused ultrasound to increase 1877 localized blood-spinal cord barrier permeability, J Control Release, vol.12, pp.268-76, 1906.

E. Ronan, N. Edjiu, O. Kroukamp, G. Wolfaardt, and R. Karshafian, USMB-induced synergistic 1908 enhancement of aminoglycoside antibiotics in biofilms, Ultrasonics, vol.69, pp.182-90, 2016.

S. Roovers, G. Lajoinie, D. Cock, I. Brans, T. Dewitte et al., , 1910.

L. I. Sc, Sonoprinting of nanoparticle-loaded microbubbles: Unraveling the 1911 multi-timescale mechanism, Biomaterials, vol.217, p.119250, 2019.

S. Roovers, G. Lajoinie, J. Prakash, M. Versluis, D. Smedt et al., Liposome-loaded 1913 microbubbles and ultrasound enhance drug delivery in a 3D tumor spheroid, Abstract 1914 book 24th Eur Symp Ultrasound Contrast Imaging, 2019.

S. Roovers, T. Segers, G. Lajoinie, J. Deprez, M. Versluis et al., The Role 1916 of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble 1917 Fundamentals to Clinical Translation, Langmuir, 2019.

I. Rosenthal, J. Z. Sostaric, and P. Riesz, Sonodynamic therapy-a review of the synergistic effects of 1919 drugs and ultrasound, Ultrason Sonochem, vol.11, pp.349-63, 2004.

S. Rossi, C. Szíjjártó, F. Gerber, G. Waton, and M. P. Krafft, Fluorous materials in microbubble 1921 engineering science and technology-Design and development of new bubble 1922 preparation and sizing technologies, J Fluorine Chem, vol.132, pp.1102-1111, 2011.

C. F. Rowlatt and S. J. Lind, Bubble collapse near a fluid-fluid interface using the spectral element 1924 marker particle method with applications in bioengineering, Int J Multiphas Flow, vol.90, pp.118-161, 1925.

R. A. Roy, S. I. Madanshetty, and R. E. Apfel, An Acoustic Backscattering Technique for the Detection 1927 of Transient Cavitation Produced by Microsecond Pulses of Ultrasound, J Acoust Soc, vol.87, pp.2451-58, 1928.

V. A. Salgaonkar, S. Datta, C. K. Holland, and T. D. Mast, Passive cavitation imaging with ultrasound 1930 arrays, J Acoust Soc Am, vol.126, pp.3071-83, 2009.

P. M. Santos and L. H. Butterfield, Dendritic Cell-Based Cancer Vaccines, J Immunol, vol.200, pp.443-1932, 2018.

T. Scarcelli, J. F. Jordão, M. A. O'reilly, N. Ellens, K. Hynynen et al., Stimulation of 1934 hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult 1935 mice, Brain Stimul, vol.7, pp.304-311, 2014.

A. J. Schissler, R. J. Gylnn, P. S. Sobieszczyk, and A. B. Waxman, Ultrasound-assisted catheter-directed 1937 thrombolysis compared with anticoagulation alone for treatment of intermediate-risk 1938 pulmonary embolism, Pulmonary Circulation, vol.8, 2018.

M. Schneider, B. Anantharam, M. Arditi, D. Bokor, A. Broillet et al., , 1940.

I. Tardy, J. Terrettaz, R. Senior, and F. Tranquart, New Ultrasound Blood Pool Agent, vol.38

, Invest Radiol, vol.46, pp.486-94, 2011.

A. R. Sever, P. Mills, S. E. Jones, W. Mali, and P. A. Jones, Sentinel node identification using 1943 microbubbles and contrast-enhanced ultrasonography, Clin Radiol, vol.67, pp.687-94, 2012.

A. R. Sever, P. Mills, J. Weeks, S. E. Jones, D. Fish et al., Preoperative needle biopsy 1945 of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced 1946 ultrasound in patients with breast cancer, AJR Am J Roentgenol, vol.199, pp.465-70, 2012.

F. E. Shamout, A. N. Pouliopoulos, P. Lee, S. Bonaccorsi, L. Towhidi et al.,

, Enhancement of non-invasive trans-membrane drug delivery using ultrasound and 1949 microbubbles during physiologically relevant flow, Ultrasound Med Biol, vol.41, pp.2435-1950, 2015.

P. S. Sheeran and P. A. Dayton, Phase-change contrast agents for imaging and therapy, Curr Pharm, vol.18, pp.2152-65, 1952.

N. Sheikov, N. Mcdannold, F. Jolesz, Y. Z. Zhang, K. Tam et al., Brain arterioles show 1954 more active vesicular transport of blood-borne tracer molecules than capillaries and 1955 venules after focused ultrasound-evoked opening of the blood-brain barrier, 1956.

, Med Biol, vol.32, pp.1399-409, 2006.

N. Sheikov, N. Mcdannold, S. Sharma, and K. Hynynen, Effect of focused ultrasound applied with 1958 an ultrasound contrast agent on the tight junctional integrity of the brain microvascular 1959 endothelium, Ultrasound Med Biol, vol.34, pp.1093-104, 2008.

N. Sheikov, N. Mcdannold, N. Vykhodtseva, F. Jolesz, and K. Hynynen, Cellular mechanisms of the 1961 blood-brain barrier opening induced by ultrasound in presence of microbubbles

, Ultrasound Med Biol, vol.30, pp.979-89, 2004.

H. Shekhar, K. B. Bader, S. W. Huang, T. Peng, S. L. Huang et al., In vitro 1964 thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator 1965 and octafluoropropane gas, Phys Med Biol, vol.62, pp.517-555, 2017.

H. Shekhar, R. T. Kleven, T. Peng, A. Palaniappan, K. B. Karani et al., , 1967.

C. K. Holland, In vitro characterization of sonothrombolysis and echocontrast agents to 1968 treat ischemic stroke, Sci Rep, vol.9, 2019.

W. H. Shentu, C. X. Yan, C. M. Liu, R. X. Qi, Y. Wang et al., Use of 1970 cationic microbubbles targeted to P-selectin to improve ultrasound-mediated gene 1971 transfection of hVEGF165 to the ischemic myocardium, J Zhejiang Univ Sci B, vol.19, pp.699-707, 1972.

Y. D. Shi, W. Y. Shi, L. Chen, and J. P. Gu, A systematic review of ultrasound-accelerated catheter-1974 directed thrombolysis in the treatment of deep vein thrombosis, J Thromb Thrombolysis, vol.45, pp.440-51, 1975.

O. Shpak, M. Verweij, J. N. De, M. Versluis, and . Droplets, Bubbles and Ultrasound Interactions

, Adv Exp Med Biol, vol.880, pp.157-74, 2016.

O. Shpak, M. Verweij, H. J. Vos, N. De-jong, D. Lohse et al., Acoustic droplet vaporization 1979 is initiated by superharmonic focusing, Proc Natl Acad Sci U S A, vol.111, pp.1697-702, 2014.

J. Silburt, N. Lipsman, and A. I. , Disrupting the blood-brain barrier with focused ultrasound: 1981 Perspectives on inflammation and regeneration, Proc Natl Acad Sci, 2017.

M. T. Silvestrini, E. S. Ingham, L. M. Mahakian, A. Kheirolomoom, Y. Liu et al.,

. St, K. D. Watson, A. W. Wong, A. M. Monjazeb, N. E. Hubbard et al., , 1984.

K. W. Ferrara, Priming is key to effective incorporation of image-guided thermal ablation 1985 into immunotherapy protocols, JCI insight, vol.2, p.90521, 2017.

J. Slikkerveer, L. Juffermans, N. Van-royen, Y. Appelman, T. R. Porter et al., Therapeutic 1987 application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary 1988 thrombosis and microvascular obstruction, Eur Heart J Acute Cardiovasc Care, vol.8, pp.45-53, 1989.

S. Snipstad, S. Berg, Y. Morch, A. Bjorkoy, E. Sulheim et al., , 1991.

A. F. Maaland, S. H. Torp, and C. De-lange-davies, Ultrasound Improves the Delivery and 1992

, Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer, 1993.

. Xenografts, Ultrasound Med Biol, vol.43, pp.2651-69, 2017.

P. Sontum, S. Kvale, A. J. Healey, R. Skurtveit, R. Watanabe et al., Cluster Therapy (ACT)--A novel concept for ultrasound mediated, targeted drug 1996 delivery, Int J Pharm, vol.495, pp.1019-1046, 1995.

N. S. Sta-maria, S. R. Barnes, M. R. Weist, D. Colcher, A. A. Raubitschek et al., , 1998.

, Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells

, PLoS One, vol.10, p.142767, 2015.

R. M. Steinman, G. Kaplan, M. D. Witmer, and Z. A. Cohn, Identification of a novel cell type in 2001 peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface 2002 markers, and maintenance in vitro, J Exp Med, vol.149, pp.1-16, 1979.

E. Stride, G. Lajoinie, M. Borden, M. Versluis, S. Cherkaoui et al., Microbubble 2004 agents: New Directions, Ultrasound Med Biol, 2019.

Q. Su, L. Li, Y. Liu, Y. Zhou, J. Wang et al., Ultrasound-targeted microbubble destruction-2006 mediated microRNA-21 transfection regulated PDCD4/NF-kappaB/TNF-alpha pathway 2007 to prevent coronary microembolization-induced cardiac dysfunction, Gene Ther, vol.22, pp.1000-1006, 2008.

M. G. Sugiyama, V. Mintsopoulos, H. Raheel, N. M. Goldenberg, J. E. Batt et al.,

W. M. Leong-poi, H. Karshafian, R. Lee, and W. L. , Lung Ultrasound and Microbubbles Enhance, 2011.

, Aminoglycoside Efficacy and Delivery to the Lung in Escherichia

, Pneumonia and Acute Respiratory Distress Syndrome, Am J Respir Crit Care Med, vol.198, pp.404-412, 2013.

T. Sun, Y. Zhang, C. Power, P. M. Alexander, J. T. Sutton et al., , 2015.

N. J. Mcdannold, Closed-loop control of targeted ultrasound drug delivery across the 2016 blood-brain/tumor barriers in a rat glioma model, Proc Natl Acad Sci, vol.114, pp.10281-90, 2017.

J. T. Sutton, K. J. Haworth, G. Pyne-geithman, and C. K. Holland, Ultrasound-mediated drug delivery 2019 for cardiovascular disease, Expert Opin Drug Deliv, vol.10, pp.573-92, 2013.

J. T. Sutton, J. L. Raymond, M. C. Verleye, G. J. Pyne-geithman, and C. K. Holland, Pulsed ultrasound 2021 enhances the delivery of nitric oxide from bubble liposomes to ex vivo porcine carotid 2022 tissue, Int J Nanomedicine, vol.9, pp.4671-83, 2014.

K. Tachibana and S. Tachibana, Albumin microbubble echo-contrast material as an enhancer for 2024 ultrasound accelerated thrombolysis, Circulation, vol.92, pp.1148-50, 1995.

B. Theek, M. Baues, T. Ojha, D. Mockel, S. K. Veettil et al.,

F. and L. T. , Sonoporation enhances liposome accumulation and penetration in tumors 2027 with low EPR, J Control Release, vol.231, pp.77-85, 2016.

E. Thevenot, J. F. Jordao, M. A. O'reilly, K. Markham, Y. Q. Weng et al.,

K. and A. I. , Targeted delivery of self-complementary adeno-associated virus serotype 9 2030 to the brain, using magnetic resonance imaging-guided focused ultrasound, Hum Gene, vol.23, pp.1144-55, 2012.

X. Q. Tian, X. W. Ni, H. L. Xu, L. Zheng, D. L. Zhuge et al., Prevention 2033 of doxorubicin-induced cardiomyopathy using targeted MaFGF mediated by 2034 nanoparticles combined with ultrasound-targeted MB destruction, Int J Nanomedicine, vol.12, pp.7103-7122, 2017.

D. Trachootham, J. Alexandre, and P. Huang, Targeting cancer cells by ROS-mediated mechanisms: 2037 a radical therapeutic approach?, Nat Rev Drug Discov, vol.8, pp.579-91, 2009.

C. H. Tsai, J. W. Zhang, Y. Y. Liao, and H. L. Liu, Real-time monitoring of focused ultrasound blood-2039 brain barrier opening via subharmonic acoustic emission detection: implementation of 2040 confocal dual-frequency piezoelectric transducers, Phys Med Biol, vol.61, pp.2926-2972, 2016.

Y. S. Tung, F. Vlachos, J. J. Choi, T. Deffieux, K. Selert et al., In vivo transcranial 2042 cavitation threshold detection during ultrasound-induced blood-brain barrier opening in 2043 mice, Phys Med Biol, vol.55, pp.6141-55, 2010.

J. Unga and M. Hashida, Ultrasound induced cancer immunotherapy, Adv Drug Deliv Rev, vol.2045, pp.144-53, 2014.

T. Van-rooij, I. Skachkov, I. Beekers, K. R. Lattwein, J. D. Voorneveld et al.,

Y. , V. Der-steen, A. F. De-jong, N. Kooiman, and K. , Viability of endothelial cells after 2048 ultrasound-mediated sonoporation: Influence of targeting, oscillation, and displacement 2049 of microbubbles, J Control Release, vol.238, pp.197-211, 2016.

A. Van-wamel, K. Kooiman, M. Harteveld, M. Emmer, F. J. Ten-cate et al.,

, Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation

, J Control Release, vol.112, pp.149-55, 2006.

A. Van-wamel, P. C. Sontum, A. Healey, S. Kvale, N. Bush et al., Acoustic Cluster, 2054.

, ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane (R) for 2055 treatment of human prostate adenocarcinoma in mice, J Control Release, vol.236, pp.15-2056, 2016.

F. Vignon, W. T. Shi, J. E. Powers, E. C. Everbach, J. J. Liu et al., , 2058.

, Cavitation Imaging, IEEE Trans Ultrason Ferroelectr Freq Control, vol.60, pp.661-70, 2013.

, VisualSonics. PN11691 -Vevo MicroMarker TM Non-Targeted Contrast Agent Kit: Protocol 2060 and Information Booklet Rev 1.4, 2016.

J. Wachsmuth, R. Chopr, and K. Hynynen, Feasibility of transient image-guided blood-spinal 2062 cord barrier disruption, AIP Conference Proceedings, pp.256-59, 2009.

J. F. Wang, Z. L. Zhao, S. X. Shen, C. X. Zhang, S. C. Guo et al., Bin 2064 JP. Selective depletion of tumor neovasculature by microbubble destruction with 2065 appropriate ultrasound pressure, Int J Cancer, vol.137, pp.2478-91, 2015.

S. Wang, O. O. Olumolade, T. Sun, G. Samiotaki, and E. E. Konofagou, Noninvasive, neuron-specific 2067 gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated 2068 virus, Gene Ther, vol.22, pp.104-114, 2015.

S. Y. Wang, C. Y. Wang, S. Unnikrishnan, A. L. Klibanov, J. A. Hossack et al., Optical 2070 Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels, 2071.

, With In Vivo Results. Invest Radiol, vol.50, pp.772-84, 2015.

T. Y. Wang, J. W. Choe, K. Pu, R. Devulapally, S. Bachawal et al.,

R. , T. L. Khuri-yakub, B. Rao, J. Paulmurugan, R. Willmann et al., Ultrasound-guided 2074 delivery of microRNA loaded nanoparticles into cancer, J Control Release, vol.203, pp.99-2075, 2015.

Y. Wang, Y. Li, K. Yan, L. Shen, W. Yang et al., Clinical study of ultrasound and 2077 microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in 2078 digestive system, Chin J Cancer Res, vol.30, pp.553-63, 2018.

D. Weber-adrian, E. Thévenot, M. A. O'reilly, W. Oakden, M. K. Akens et al.,

K. Coultes, A. Burgess, J. Finkelstein, A. J. Yee, C. M. Whyne et al., Gene delivery to the spinal cord using MRI-guided 2082 focused ultrasound, Gene Ther, vol.22, pp.568-77, 2015.

J. S. Weber, American Society of Clinical Oncology 2084 educational book, Annual Meeting, vol.37, pp.205-214, 2017.

Y. L. Wei, N. Shang, J. H. He, Y. Pan, Y. W. Xiao et al.,

, Penetration of different molecule sizes upon ultrasound combined with microbubbles in 2088 a superficial tumour model, J Drug Target, 2019.

H. L. Weiss, P. Selvaraj, K. Okita, Y. Matsumoto, A. Voie et al., Mechanical clot 2090 damage from cavitation during sonothrombolysis, J Acoust Soc Am, vol.133, pp.3159-75, 2013.

G. Weller, F. S. Villanueva, A. L. Klibanov, and W. R. Wagner, Modulating targeted adhesion of an 2092 ultrasound contrast agent to dysfunctional endothelium, Ann Biomed Eng, vol.30, pp.1012-2093, 2002.

W. Wiedemair, Z. Tukovic, H. Jasak, D. Poulikakos, and V. Kurtcuoglu, The breakup of intravascular 2095 microbubbles and its impact on the endothelium, Biomech Model Mechanobiol, vol.16, pp.611-635, 2017.

C. C. Winterbourn, Reconciling the chemistry and biology of reactive oxygen species, Nat Chem, vol.4, pp.278-86, 2008.

J. Wu, Theoretical study on shear stress generated by microstreaming surrounding contrast 2100 agents attached to living cells, Ultrasound Med Biol, vol.28, pp.125-134, 2002.

A. Abrahao, Y. Meng, M. Llinas, Y. Huang, C. Hamani et al.,

H. K. Se, N. Lipsman, and L. Zinman, Motor Cortex Blood-Brain Barrier Opening in 1254

, Amyotrophic Lateral Sclerosis using MR-Guided Focused Ultrasound: A First-in-Human

, Trial. Nat Commun, vol.10, p.4373, 2019.

C. N. Acconcia, R. M. Jones, D. E. Goertz, M. A. O'reilly, and K. Hynynen, Megahertz rate, volumetric 1257 imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver 1258 array, Phys Med Biol, vol.62, pp.31-40, 2017.

C. N. Acconcia, B. Y. Leung, and D. E. Goertz, The microscale evolution of the erosion front of blood 1260 clots exposed to ultrasound stimulated microbubbles, J Acoust Soc Am, vol.139, p.135, 2016.

A. Agarwal, J. Ng, W. Liu, and Y. , Removal of biofilms by intermittent low-intensity 1262 ultrasonication triggered bursting of microbubbles, Biofouling, vol.30, pp.359-65, 2014.

A. V. Alexandrov, A. M. Demchuk, W. S. Burgin, D. J. Robinson, J. C. Grotta et al.,

, Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the 1265 CLOTBUST trial, J Neuroimaging, vol.14, pp.113-120, 2004.

A. V. Alexandrov, A. W. Wojner, J. C. Grotta, and C. Investigators, CLOTBUST: design of a randomized 1267 trial of ultrasound-enhanced thrombolysis for acute ischemic stroke, J Neuroimaging, vol.1268, pp.108-120, 2004.

R. Alkins, A. Burgess, M. Ganguly, G. Francia, R. Kerbel et al., Focused 1270 ultrasound delivers targeted immune cells to metastatic brain tumors, Cancer Res, vol.1271, pp.1892-1901, 2013.

R. Alkins, A. Burgess, R. Kerbel, W. S. Wels, and K. Hynynen, Early treatment of HER2-amplified 1273 brain tumors with targeted NK-92 cells and focused ultrasound improves survival, Oncol, vol.18, pp.974-81, 1274.

S. C. De-smedt and S. Meairs, Focal Delivery of AAV2/1-transgenes Into the Rat Brain by 1277

, Localized Ultrasound-induced BBB Opening, Mol Ther Nucleic Acids, vol.2, p.73, 2013.

C. Arvanitis and N. Mcdannold, Transcranial spatial and temporal assessment of microbubble 1279 dynamics for brain therapies, Proc Meet Acoust, vol.19, p.75021, 2013.

C. D. Arvanitis, M. S. Livingstone, and N. Mcdannold, Combined ultrasound and MR imaging to guide 1281 focused ultrasound therapies in the brain, Phys Med Biol, vol.58, pp.4749-61, 2013.

C. D. Arvanitis, M. S. Livingstone, N. Vykhodtseva, and N. Mcdannold, Controlled ultrasound-induced 1283 blood-brain barrier disruption using passive acoustic emissions monitoring, PLoS One, vol.1284, p.45783, 2012.

C. D. Arvanitis and N. Mcdannold, Integrated ultrasound and magnetic resonance imaging for 1286 simultaneous temperature and cavitation monitoring during focused ultrasound therapies

, Med Phys, vol.40, p.112901, 2013.

M. Aryal, K. Fischer, C. Gentile, S. Gitto, Y. Z. Zhang et al., , p.1289

, Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and 1290

. Microbubbles, PLoS One, vol.12, p.166061, 2017.

M. Aryal, N. Vykhodtseva, Y. Z. Zhang, J. Park, and N. Mcdannold, Multiple treatments with 1292 liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and blood-1293 brain barriers improve outcomes in a rat glioma model, J Control Release, vol.169, pp.103-1294, 2013.

L. Auboire, C. A. Sennoga, J. M. Hyvelin, F. Ossant, J. M. Escoffre et al.,

, Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review 1297 of in-vivo preclinical studies, Endocrinology, vol.13, pp.1492-505, 2018.

K. B. Bader, M. J. Gruber, and C. K. Holland, Shaken and stirred: mechanisms of ultrasound-enhanced 1302 thrombolysis, Ultrasound Med Biol, vol.41, pp.187-96, 2015.

K. B. Bader, K. J. Haworth, H. Shekhar, A. D. Maxwell, T. Peng et al.,

, Efficacy of histotripsy combined with rt-PA in vitro, Phys Med Biol, vol.61, pp.5253-74, 2016.

K. B. Bader and C. K. Holland, Gauging the likelihood of stable cavitation from ultrasound contrast 1306 agents, Phys Med Biol, vol.58, pp.127-171, 2013.

K. B. Bader, E. Vlaisavljevich, and A. D. Maxwell, For Whom the Bubble Grows: Physical Principles 1308 of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy, Ultrasound Med, vol.45, pp.1056-80, 1309.

Y. J. Bae, Y. I. Yoon, T. J. Yoon, and H. J. Lee, Ultrasound-Guided Delivery of siRNA and a 1311

, Chemotherapeutic Drug by Using Microbubble Complexes: In Vitro and In Vivo 1312 Evaluations in a Prostate Cancer Model, Korean J Radiol, vol.17, pp.497-508, 2016.

S. Bao, B. D. Thrall, and D. L. Miller, Transfection of a reporter plasmid into cultured cells by 1314 sonoporation in vitro, Ultrasound Med Biol, vol.23, pp.953-59, 1997.

Y. Barenholz, Doxil (R) -The first FDA-approved nano-drug: Lessons learned, J Control, vol.160, pp.117-151, 1316.

I. Beekers, T. Van-rooij, M. D. Verweij, M. Versluis, N. De-jong et al., Acoustic 1318 Characterization of a Vessel

, Drug Delivery, IEEE Trans Ultrason Ferroelectr Freq Control, vol.65, pp.570-81, 2018.

E. Beguin, S. Shrivastava, N. V. Dezhkunov, A. P. Mchale, J. F. Callan et al., , p.1321

, Multibubble Sonoluminescence Using Therapeutic Ultrasound and Microbubbles

, Appl Mater Interfaces, vol.11, pp.19913-19932, 2019.

J. Field, L. Harmann, W. M. Chilian, J. Linden, and J. R. Lindner, Augmentation of Muscle Blood 1325 Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling, Circulation, vol.135, pp.1240-52, 1326.

J. T. Belcik, B. H. Mott, A. Xie, Y. Zhao, S. Kim et al.,

, Augmentation of limb perfusion and reversal of tissue ischemia produced by ultrasound-1329 mediated microbubble cavitation, Circ Cardiovasc Imaging, vol.8, 2015.

T. B. Benjamin and A. T. Ellis, The Collapse of Cavitation Bubbles and the Pressures thereby 1331 Produced against Solid Boundaries, Phil Trans R Soc A, vol.260, pp.221-261, 1966.

C. Bing, Y. Hong, C. Hernandez, M. Rich, B. Cheng et al.,

M. Exner, A. Chopra, and R. , Characterization of different bubble formulations for blood-brain 1334 barrier opening using a focused ultrasound system with acoustic feedback control, Sci 1335 Rep, vol.8, p.7986, 2018.

G. Bioley, A. Lassus, J. Terrettaz, F. Tranquart, and B. Corthesy, Long-term persistence of immunity 1337 induced by OVA-coupled gas-filled microbubble vaccination partially protects mice 1338 against infection by OVA-expressing Listeria, Biomaterials, vol.57, pp.153-60, 2015.

G. P. Biro and P. Blais, Perfluorocarbon blood substitutes, Crit Rev Oncol Hematol, vol.6, pp.311-74, 1987.

J. Brüssler, B. Strehlow, A. Becker, R. Schubert, J. Schummelfeder et al.,

, Nanoscaled ultrasound contrast agents for enhanced sonothrombolysis, Colloid Surface 1342 B, vol.172, pp.728-761, 2018.

S. Bulner, A. Prodeus, J. Gariepy, K. Hynynen, and D. E. Goertz, Enhancing Checkpoint Inhibitor 1344 Therapy with Ultrasound Stimulated Microbubbles, Ultrasound Med Biol, vol.45, pp.500-1345, 2019.

A. Burgess, S. Dubey, S. Yeung, O. Hough, N. Eterman et al., Alzheimer disease 1347 in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus 1348 opens the blood-brain barrier and improves pathologic abnormalities and behavior, Radiology, vol.273, pp.736-781, 1349.

A. Burgess, Y. X. Huang, A. C. Waspe, M. Ganguly, D. E. Goertz et al.,

, Focused Ultrasound (HIFU) for Dissolution of Clots in a Rabbit Model of Embolic 1352

, Stroke. PLoS One, vol.7, 2012.

M. T. Burgess and T. M. Porter, Control of Acoustic Cavitation for Efficient Sonoporation with Phase

, Shift Nanoemulsions, Ultrasound Med Biol, vol.45, pp.846-58, 2019.

C. W. Burke, A. E. Timbie, K. Kilbanov, A. L. Price, and R. J. , Ultrasound-activated Agents 1356 Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor 1357 Growth and Improve Survival, Mol Ther, vol.22, pp.321-349, 2014.

B. Campbell, P. J. Mitchell, L. Churilov, N. Yassi, T. J. Kleinig et al., , p.1359

H. M. Dewey, V. Thijs, R. Scroop, M. Simpson, M. Brooks et al., , p.1360

T. Wijeratne, T. Ang, F. Miteff, C. R. Levi, E. Rodrigues et al.,

C. , B. P. Rice, H. De-villiers, L. Brown, H. Redmond et al.,

W. Wong, A. A. Muller, C. Coulthard, A. Mitchell, K. Clouston et al.,

H. Phan, T. G. Chong, W. Chandra, R. V. Slater, L. A. Krause et al., , p.1364

B. S. Steinfort, C. F. Bladin, G. Sharma, P. M. Desmond, M. W. Parsons et al., Davis 1365 SM, Investigators E-IT. Tenecteplase versus Alteplase before Thrombectomy for, p.1366

, Ischemic Stroke, New Engl J Med, vol.378, pp.1573-82, 2018.

W. J. Cao, J. D. Rosenblat, N. C. Roth, M. A. Kuliszewski, P. N. Matkar et al., , p.1368

H. Leong-poi, Therapeutic Angiogenesis by Ultrasound-Mediated MicroRNA-126-3p

. Delivery, Arterioscler Thromb Vasc Biol, vol.35, pp.2401-2412, 2015.

Y. Cao, Y. Chen, T. Yu, Y. Guo, F. Liu et al., Drug 1371 Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused

, Ultrasound. Theranostics, vol.8, pp.343-345, 2016.

E. L. Carstensen and H. G. Flynn, The Potential for Transient Cavitation with Microsecond Pulses of

, Ultrasound, Ultrasound Med Biol, vol.8, pp.720-744, 1982.

C. F. Caskey, S. Qin, P. A. Dayton, and K. W. Ferrara, Microbubble tunneling in gel phantoms, J Acoust, p.1380

, Soc Am, vol.125, pp.183-192, 2009.

H. Chen, A. A. Brayman, W. Kreider, M. R. Bailey, and T. J. Matula, Observations of translation and 1382 jetting of ultrasound-activated microbubbles in mesenteric microvessels, 1383.

, Med Biol, vol.37, pp.2139-2187, 2011.

P. Y. Chen, H. L. Liu, M. Y. Hua, H. W. Yang, C. Y. Huang et al., , p.1385

H. C. Tsai, S. M. Chen, Y. J. Lu, J. J. Wang, T. C. Yen et al., Novel magnetic/ultrasound focusing system enhances 1387 nanoparticle drug delivery for glioma treatment, Neuro Oncol, vol.12, pp.1050-60, 2010.

S. Chen, J. Chen, P. Huang, X. L. Meng, S. Clayton et al., Myocardial 1389 regeneration in adriamycin cardiomyopathy by nuclear expression of GLP1 using 1390 ultrasound targeted microbubble destruction, Biochem Biophys Res Commun, vol.1391, pp.823-832, 2015.

S. Chen, J. Chen, X. L. Meng, J. S. Shen, J. Huang et al.,

, ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac 1394 progenitor cells, Oncotarget, vol.7, pp.80391-403, 2016.

X. Chen, R. S. Leow, Y. Hu, J. M. Wan, and A. C. Yu, sonothombolysis versus non-sonothombolysis in patients with acute ischemic stroke: A 1399 meta-analysis of randomized controlled trials, Journal of the Royal Society Interface, vol.11, 2014.

R. W. Childs and M. Carlsten, Therapeutic approaches to enhance natural killer cell cytotoxicity 1401 against cancer: the force awakens, Nat Rev Drug Discov, vol.14, pp.487-98, 2015.

H. Cho, H. Y. Lee, M. Han, J. R. Choi, S. Ahn et al., Localized Down-regulation 1403 of P-glycoprotein by Focused Ultrasound and Microbubbles induced Blood-Brain Barrier 1404 Disruption in Rat Brain, Sci Rep, vol.6, p.31201, 2016.

J. J. Choi, R. C. Carlisle, C. Coviello, L. Seymour, and C. Coussios, Non-invasive and real-time 1406 passive acoustic mapping of ultrasound-mediated drug delivery, Phys Med Biol, vol.1407, pp.4861-77, 2014.

J. Cowley and S. Mcginty, A mathematical model of sonoporation using a liquid-crystalline shelled 1409 microbubble, Ultrasonics, vol.96, pp.214-233, 2019.

C. Crake, S. T. Brinker, C. M. Coviello, M. S. Livingstone, and N. J. Mcdannold, A dual-mode 1411 hemispherical sparse array for 3D passive acoustic mapping and skull localization within 1412 a clinical MRI guided focused ultrasound device, Phys Med Biol, vol.63, p.65008, 2018.

A. Daecher, M. Stanczak, J. B. Liu, J. Zhang, S. S. Du et al.,

, Localized microbubble cavitation-based antivascular therapy for improving HCC 1415 treatment response to radiotherapy, Cancer Lett, vol.411, pp.100-105, 2017.

S. Datta, C. C. Coussios, L. E. Mcadory, J. Tan, T. Porter et al.,

, Correlation of cavitation with ultrasound enhancement of thrombolysis, Ultrasound Med, vol.32, pp.1257-67, 1418.

P. Dayton, A. Klibanov, G. Brandenburger, and K. Ferrara, Acoustic radiation force in vivo: A 1420 mechanism to assist targeting of microbubbles, Ultrasound Med Biol, vol.25, pp.1195-201, 1999.

, Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant 1423 for uptake via membrane pores or endocytosis, J Control Release, vol.197, pp.20-28, 2015.

D. Victor, M. D. Barnsley, L. C. Carugo, D. Owen, J. Coussios et al.,

, Sonothrombolysis with Magnetically Targeted Microbubbles, Ultrasound Med Biol, vol.45, pp.1151-63, 1426.

T. Deffieux, G. Montaldo, M. Tanter, and M. Fink, Shear wave spectroscopy for in vivo quantification 1428 of human soft tissues visco-elasticity, IEEE Trans Med Imaging, vol.28, pp.313-335, 2009.

®. Definity, US Food and Drug Administration, 2011.

J. Deng, Q. Huang, F. Wang, Y. Liu, Z. Wang et al., The role of caveolin-1 1431 in blood-brain barrier disruption induced by focused ultrasound combined with 1432 microbubbles, J Mol Neurosci, vol.46, pp.677-87, 2012.

L. Deng, M. A. O'reilly, R. M. Jones, R. An, and K. Hynynen, A multi-frequency sparse hemispherical 1434 ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous 1435 cavitation mapping, Phys Med Biol, vol.61, pp.8476-501, 2016.

Q. Deng, B. Hu, S. Cao, H. N. Song, J. L. Chen et al., Improving the efficacy of therapeutic 1437 angiogenesis by UTMD-mediated Ang-1 gene delivery to the infarcted myocardium

, J Mol Med, vol.36, pp.335-379, 2015.

H. Dewitte, S. Van-lint, C. Heirman, K. Thielemans, D. Smedt et al.,

, The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for 1441 ultrasound-triggered cancer immunotherapy, J Control Release, vol.194, pp.28-36, 2014.

H. Dewitte, K. Vanderperren, H. Haers, E. Stock, L. Duchateau et al., , 1443.

L. I. Sc and S. C. De, Theranostic mRNA-loaded Microbubbles in the Lymphatics of ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic 1448 cancer, J Control Release, vol.243, pp.172-81, 2016.

A. J. Dixon, J. Li, J. Rickel, A. L. Klibanov, Z. Y. Zuo et al., , p.1450

, Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model 1451 of Ischemic Stroke, Ann Biomed Eng, vol.47, pp.1012-1034, 2019.

A. A. Doinikov and A. Bouakaz, Theoretical investigation of shear stress generated by a contrast 1453 microbubble on the cell membrane as a mechanism for sonoporation, J Acoust Soc Am, vol.128, pp.11-20, 1454.

B. Dollet, P. Marmottant, and V. Garbin, Bubble dynamics in soft and biological matter, Annu Rev, p.1456
URL : https://hal.archives-ouvertes.fr/hal-02004184

, Fluid Mech, vol.51, pp.331-55, 2019.

Y. Dong, J. Li, P. Li, and J. Yu, Ultrasound Microbubbles Enhance the Activity of Vancomycin 1458

, Against Staphylococcus epidermidis Biofilms In Vivo, J Ultrasound Med, vol.37, pp.1379-1459, 2018.

Y. Dong, Y. Xu, P. Li, C. Wang, Y. Cao et al., Antibiofilm effect of ultrasound combined with 1461 microbubbles against Staphylococcus epidermidis biofilm, Int J Med Microbiol, vol.307, pp.321-349, 1462.

M. E. Downs, A. Buch, C. Sierra, M. E. Karakatsani, T. Teichert et al., Ferrera 1464 VP. Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused 1465

, Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task

, PLoS One, vol.10, p.125911, 2015.

M. Dumantepe, I. Uyar, B. Teymen, O. Ugur, and Y. Enc, Improvements in Pulmonary Artery, vol.29, pp.455-63, 1468.

H. P. Ebben, J. H. Nederhoed, R. J. Lely, W. Wisselink, K. Yeung et al., Microbubbles 1472 and UltraSound-accelerated Thrombolysis (MUST) for peripheral arterial occlusions: 1473 protocol for a phase II single-arm trial, Bmj Open, vol.7, 2017.

S. Eggen, S. Fagerland, Ý. Mørch, R. Hansen, K. Søvik et al.,

A. A. Mb, B. Angelsen, and C. De-lange-davies, Ultrasound-enhanced drug delivery 1476 in prostate cancer xenografts by nanoparticles stabilizing microbubbles, J Control, vol.187, pp.39-49, 1477.

S. A. Elder, Cavitation microstreaming, J Acoust Soc Am, vol.31, pp.54-64, 1958.

R. P. Engelberger and N. Kucher, Ultrasound-assisted thrombolysis for acute pulmonary embolism: 1480 a systematic review, Eur Heart J, vol.35, pp.758-64, 2014.

J. M. Escoffre, C. Mannaris, B. Geers, A. Novell, I. Lentacker et al.,

, Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-1483 triggered drug delivery, IEEE Trans Ultrason Ferroelectr Freq Control, vol.60, pp.78-87, 2013.

E. C. Everbach and C. W. Francis, Cavitational mechanisms in ultrasound-accelerated thrombolysis at 1485

. Mhz, Ultrasound Med Biol, vol.26, pp.1153-60, 2000.

T. Faez, M. Emmer, K. Kooiman, M. Versluis, A. F. Van-der-steen et al., 20 years of 1487 ultrasound contrast agent modeling, IEEE Trans Ultrason Ferroelectr Freq Control, vol.60, pp.7-20, 1488.

Z. Fan, D. Chen, and C. X. Deng, Improving ultrasound gene transfection efficiency by controlling 1490 ultrasound excitation of microbubbles, J Control Release, vol.170, pp.401-414, 2013.

Z. Fan, H. Liu, M. Mayer, and C. X. Deng, Spatiotemporally controlled single cell sonoporation, Proc, vol.1492

, Natl Acad Sci U S A, vol.109, pp.16486-91, 2012.

, Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct 1495

, Mechanisms. PLoS One, vol.11, p.156754, 2016.

K. W. Ferrara, M. A. Borden, and H. Zhang, Lipid-Shelled Vehicles: Engineering for Ultrasound 1497

, Molecular Imaging and Drug Delivery, Acc Chem Res, vol.42, pp.881-92, 2009.

S. M. Fix, V. Papadopoulou, H. Velds, S. K. Kasoji, J. N. Rivera et al.,

, Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model -1500 A preliminary study, PLoS One, vol.13, 2018.

S. P. Fletcher and O. Ma, Analysis of Multifrequency and Phase Keying Strategies for

, Focusing Ultrasound to the Human Vertebral Canal, IEEE Trans Ultrason Ferroelectr, p.1503

, Freq Control, vol.65, pp.2322-2353, 2018.

S. M. Flight, P. P. Masci, M. F. Lavin, and P. J. Gaffney, Resistance of porcine blood clots to lysis relates 1505 to poor activation of porcine plasminogen by tissue plasminogen activator, Blood Coagul, vol.17, pp.417-437, 1506.

E. B. Flint and K. S. Suslick, The temperature of cavitation, Science, vol.253, pp.1397-1406, 1991.

H. G. Flynn, Physics of acoustic cavitation in liquids

H. G. Flynn, Cavitation Dynamics: I. Mathematical Formulation, J Acoust Soc Am, vol.1511, pp.1379-96, 1975.

H. G. Flynn, Cavitation Dynamics: II. Free pulsations and models for cavitation bubbles, J, vol.1513

, Acoust Soc Am, vol.58, pp.1160-70, 1975.

H. G. Flynn, Generation of transient cavities in liquids by microsecond pulses of ultrasound, J, vol.1515

, activity of cells exposed to ultrasound in the presence of contrast agents, Acoust Soc Am, vol.72, pp.2723-2732, 1518.

Y. Y. Fu, L. Zhang, Y. Yang, C. W. Liu, Y. N. He et al., Synergistic antibacterial effect of 1520 ultrasound microbubbles combined with chitosan-modified polymyxin B-loaded 1521 liposomes on biofilm-producing Acinetobacter baumannii, Int J Nanomedicine, vol.1522, pp.1805-1820, 2019.

D. A. Gabriel, K. Muga, and E. M. Boothroyd, The Effect of Fibrin Structure on Fibrinolysis, J Biol, vol.267, pp.24259-63, 1524.

M. J. Garcia, Endovascular Management of Acute Pulmonary Embolism Using the Ultrasound-1526

, Enhanced EkoSonic System. Seminars in Interventional Radiology, vol.32, pp.384-87, 2015.

M. Gauberti, Reperfusion in acute ischaemic stroke by sonothrombolysis, Lancet Neurol, vol.1528, pp.320-341, 2019.

D. E. Goertz, An overview of the influence of therapeutic ultrasound exposures on the 1530 vasculature: high intensity ultrasound and microbubble-mediated bioeffects, Int J 1531 Hyperthermia, vol.31, pp.134-178, 2015.

B. Goh, M. Conneely, H. Kneupner, T. Palmer, E. Klaseboer et al., , 2015.

, High-speed imaging of ultrasound-mediated bacterial biofilm disruption. 6th European 1534 Conference of the International Federation for Medical and Biological Engineering: 1535 Sprinter International Publishing, pp.533-569

S. Goutal, M. Gerstenmayer, S. Auvity, F. Caillé, S. Mériaux et al.,

, Physical blood-brain barrier disruption induced by focused ultrasound does not overcome 1538 the transporter-mediated efflux of erlotinib, J Control Release, vol.292, pp.210-230, 2018.

A. Goyal, F. Yu, M. G. Tenwalde, X. C. Chen, A. Althouse et al.,

S. M. Graham, R. Carlisle, J. J. Choi, M. Stevenson, A. R. Shah et al., , p.1544

L. Seymour and C. C. Coussios, Inertial cavitation to non-invasively trigger and monitor 1545 intratumoral release of drug from intravenously delivered liposomes, J Control Release, vol.1546, pp.101-108, 2014.

G. Navarro, A. Bjorklund, A. T. Chekenya, and M. , Therapeutic potential and challenges of natural 1548 killer cells in treatment of solid tumors, Front Immunol, vol.6, p.202, 2015.

H. Guo, Z. Wang, Q. Du, P. Li, Z. Wang et al., Stimulated phase-shift acoustic nanodroplets 1550 enhance vancomycin efficacy against methicillin-resistant Staphylococcus aureus 1551 biofilms, Int J Nanomed, vol.12, pp.4679-90, 2017.

X. Guo, C. Cai, G. Xu, Y. Yang, J. Tu et al., Interaction between cavitation 1553 microbubble and cell: A simulation of sonoporation using boundary element method 1554 (BEM), Ultrason Sonochem, vol.39, pp.863-71, 2017.

R. Gupta, J. Shea, C. Scafe, A. Shurlygina, and N. Rapoport, Polymeric micelles and nanoemulsions 1556 as drug carriers: Therapeutic efficacy, toxicity, and drug resistance, J Control Release, vol.1557, pp.70-77, 2015.

M. Gyöngy and C. C. Coussios, Passive cavitation mapping for localization and tracking of bubble 1559 dynamics, J Acoust Soc Am, vol.128, pp.175-80, 2010.

M. F. Hamilton, D. T. Blackstock, . Nonlinear, and . Melville, , 1561.

Y. W. Han, A. Ikegami, P. Chung, L. Zhang, and C. X. Deng, Sonoporation is an efficient tool for 1563 intracellular fluorescent dextran delivery and one-step double-crossover mutant 1564 construction in Fusobacterium nucleatum, Appl Environ Microbiol, vol.73, pp.3677-83, 2007.

, Passive Cavitation Imaging, IEEE Trans Ultrason Ferroelectr Freq Control, vol.64, pp.177-1567, 2017.

Y. He, B. Zhang, Y. Chen, J. Q. Wu, J. Yan et al., Image-Guided Hydrogen Gas Delivery 1569 for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles

, Appl Mater Interfaces, vol.9, pp.21190-99, 2017.

B. Helfield, X. Chen, S. C. Watkins, and F. S. Villanueva, Biophysical insight into mechanisms of 1572 sonoporation, Proc Natl Acad Sci U S A, vol.113, pp.9983-9991, 2016.

S. Hilgenfeldt, D. Lohse, and M. Zomack, Sound scattering and localized heat deposition of pulse-1574 driven microbubbles, J Acoust Soc Am, vol.107, pp.3530-3569, 2000.

K. E. Hitchcock, N. M. Ivancevich, K. J. Haworth, D. Stamper, D. C. Vela et al., , p.1576

G. J. Geithman and C. K. Holland, Ultrasound-enhanced rt-PA thrombolysis in an ex vivo 1577 porcine carotid artery model, Ultrasound Med Biol, vol.37, pp.1240-51, 2011.

Y. J. Ho, T. C. Wang, C. H. Fan, and C. K. Yeh, Spatially Uniform Tumor Treatment and Drug Penetration 1579 by Regulating Ultrasound with Microbubbles, ACS Appl Mater Interfaces, vol.1580, pp.17784-91, 2018.

R. G. Holt and R. A. Roy, Measurements of bubble-enhanced heating from focused, MHz-frequency 1582 ultrasound in a tissue-mimicking material, Ultrasound Med Biol, vol.27, pp.1399-412, 2001.

H. Horsley, J. Owen, R. Browning, D. Carugo, J. Malone-lee et al., Ultrasound-1584 activated microbubbles as a novel intracellular drug delivery system for urinary tract 1585 infection, J Control Release, vol.301, pp.166-75, 2019.

N. Hosseinkhah, D. E. Goertz, and K. Hynynen, Microbubbles and blood-brain barrier opening: a 1587 numerical study on acoustic emissions and wall stress predictions, to bacterial cells and enhancement of metabolic activities. Sci Rep, vol.62, p.192, 2015.

W. Hu, G. Wang, D. Huang, M. Sui, and Y. Xu, Cancer Immunotherapy Based on Natural Killer Cells: 1593 Current Progress and New Opportunities, Front Immunol, vol.10, p.1205, 2019.

X. Hu, A. Kheirolomoom, L. M. Mahakian, J. R. Beegle, D. E. Kruse et al.,

, Insonation of targeted microbubbles produces regions of reduced blood flow within 1596 tumor vasculature, Invest Radiol, vol.47, pp.398-405, 2012.

Y. Hu, J. M. Wan, and A. C. Yu, Membrane perforation and recovery dynamics in microbubble-1598 mediated sonoporation, Ultrasound Med Biol, vol.39, pp.2393-405, 2013.

S. W. Huang, H. Shekhar, and C. K. Holland, Comparative lytic efficacy of rt-PA and ultrasound in 1600 porcine versus human clots, PLoS One, vol.12, 2017.

S. J. Hunt, T. Gade, M. C. Soulen, S. Pickup, and C. M. Sehgal, Antivascular ultrasound therapy: magnetic 1602 resonance imaging validation and activation of the immune response in murine 1603 melanoma, J Ultrasound Med, vol.34, pp.275-87, 2015.

K. Hynynen, N. Mcdannold, N. Vykhodtseva, and F. A. Jolesz, Noninvasive MR imaging-guided focal 1605 opening of the blood-brain barrier in rabbits, Radiology, vol.220, pp.640-646, 2001.

A. Idbaih, M. Canney, L. Belin, C. Desseaux, A. Vignot et al., , p.1607

D. Leclercq, A. Bissery, Y. De-rycke, C. Trosch, L. Capelle et al., , p.1608

C. Dehais, C. Houillier, F. Laigle-donadey, B. Mathon, A. Andre et al., , p.1609

J. Y. Delattre and A. Carpentier, Safety and Feasibility of Repeated and Transient Blood-Brain 1610

, Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma, Clin, 1611.

, Cancer Res, vol.25, pp.3793-801, 2019.

, Heterogeneously Sonoporated Cells by Microbubbles with Single-Pulse Ultrasound

, Ultrasound Med Biol, vol.44, pp.1074-85, 2018.

R. M. Jones, L. Deng, K. Leung, D. Mcmahon, M. A. O'reilly et al., Three-dimensional 1616 transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-1617 brain barrier opening, Theranostics, vol.8, pp.2909-2935, 2018.

R. M. Jones, M. A. O'reilly, and K. Hynynen, Transcranial passive acoustic mapping with 1619 hemispherical sparse arrays using CT-based skull-specific aberration corrections: a 1620 simulation study, Phys Med Biol, vol.58, pp.4981-5005, 2013.

R. M. Jones, M. A. O'reilly, and K. Hynynen, Experimental demonstration of passive acoustic imaging 1622 in the human skull cavity using CT-based aberration corrections, Med Phys, vol.1623, pp.4385-400, 2015.

J. F. Jordão, E. Thévenot, K. Markham-coultes, T. Scarcelli, Y. Q. Weng et al., , p.1625

Y. Huang, J. Mclaurin, K. Hynynen, and A. I. , Amyloid-? plaque reduction, endogenous 1626 antibody delivery and glial activation by brain-targeted

, Exp Neurol, vol.248, pp.16-29, 2013.

E. K. Juang, D. Cock, I. Keravnou, C. Gallagher, M. K. Keller et al.,

, Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble

, Mediated Drug Delivery, Langmuir, vol.35, pp.10128-10166, 2019.

M. R. Junttila and F. J. De-sauvage, Influence of tumour micro-environment heterogeneity on 1632 therapeutic response, Nature, vol.501, pp.346-54, 2013.

H. A. Kamimura, J. Flament, J. Valette, A. Cafarelli, A. Badin et al.,

, Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier 1635 disruption in non-human primates under magnetic resonance guidance, J Cereb Blood, p.1636

, Flow Metab, vol.39, pp.1191-203, 2019.

, Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig

, Ultrasound Med Biol, vol.42, pp.2676-86, 2016.

D. N. Khalil, E. L. Smith, R. J. Brentjens, and J. D. Wolchok, The future of cancer treatment: 1641 immunomodulation, CARs and combination immunotherapy, Nat Rev Clin Oncol, vol.1642, p.394, 2016.

J. P. Kilroy, A. H. Dhanaliwala, A. L. Klibanov, D. K. Bowles, B. R. Wamhoff et al.,

, Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles, 1645.

, Biomed Eng, vol.43, pp.2642-51, 2015.

J. P. Kilroy, A. L. Klibanov, B. R. Wamhoff, D. K. Bowles, and J. A. Hossack, Localized in vivo model drug 1647 delivery with intravascular ultrasound and microbubbles, Ultrasound Med Biol, vol.1648, pp.2458-67, 2014.

H. Kim, G. L. Britton, T. Peng, C. K. Holland, D. D. Mcpherson et al., Nitric oxide-loaded 1650 echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage

, Int J Nanomedicine, vol.9, pp.155-65, 2014.

R. T. Kleven, K. B. Karani, N. G. Salido, H. Shekhar, K. J. Haworth et al., Holland 1653 CK. The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro

, Phys Med Biol, vol.64, p.165015, 2019.

J. Kolb and W. L. Nyborg, Small-Scale Acoustic Streaming in Liquids, J Acoust Soc Am, vol.1656, pp.1237-1279, 1956.

K. Kooiman, H. J. Vos, M. Versluis, and N. De-jong, Acoustic behavior of microbubbles and 1658 implications for drug delivery, Adv Drug Deliv Rev, vol.72, pp.28-48, 2014.

J. A. Kopechek, A. R. Carson, C. F. Mctiernan, X. Chen, B. Hasjim et al., , p.1660

F. S. Villanueva, Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a, vol.5, pp.1378-87, 2015.

J. A. Kopechek, E. Park, C. S. Mei, N. J. Mcdannold, and T. M. Porter, Accumulation of phase-shift 1664 nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo

, Healthc Eng, vol.4, pp.109-135, 2013.

J. A. Kopechek, E. J. Park, Y. Z. Zhang, N. I. Vykhodtseva, N. J. Mcdannold et al., Cavitation-1667 enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase 1668 shift nanoemulsions, Phys Med Biol, vol.59, pp.3465-81, 2014.

K. Koshiyama and S. Wada, Molecular dynamics simulations of pore formation dynamics during 1670 the rupture process of a phospholipid bilayer caused by high-speed equibiaxial stretching

, J Biomech, vol.44, pp.2053-2061, 2011.

S. Kotopoulis, G. Dimcevski, O. H. Gilja, D. Hoem, and M. Postema, Treatment of human pancreatic 1673 cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study

, Med Phys, vol.40, p.72902, 2013.

S. Kotopoulis, E. Stigen, M. Popa, M. M. Safont, A. Healey et al., Sonoporation with Acoustic Cluster Therapy (ACT®) induces 1677 transient tumour volume reduction in a subcutaneous xenograft model of pancreatic 1678 ductal adenocarcinoma, J Control Release, vol.245, pp.70-80, 2017.

Z. I. Kovacs, S. R. Burks, J. A. Frank, . Reply, and . Silburt, Concerning sterile inflammation 1680 following focused ultrasound and microbubbles in the brain, Proc Natl Acad Sci, 16812017.

Z. I. Kovacs, S. Kim, N. Jikaria, F. Qureshi, M. B. Lewis et al.,

, Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation

, E75-E84. for therapeutic and diagnostic applications, Proc Natl Acad Sci U S A, vol.114, pp.1177-89, 2000.

N. Kudo, High-Speed In Situ Observation System for Sonoporation of Cells With Size-and 1688

, Position-Controlled Microbubbles, IEEE Trans Ultrason Ferroelectr Freq Control, vol.64, pp.273-80, 1689.

N. Kudo and Y. Kinoshita, Effects of cell culture scaffold stiffness on cell membrane damage 1691 induced by sonoporation, J Med Ultrason, vol.41, pp.411-431, 2014.

P. Lai, C. Tarapacki, W. T. Tran, E. Kaffas, A. Lee et al.,

A. and C. Gj, Breast tumor response to ultrasound mediated excitation of 1694 microbubbles and radiation therapy in vivo, Oncoscience, vol.3, pp.98-108, 2016.

T. Lammers, F. Kiessling, W. E. Hennink, and G. Storm, Drug targeting to tumors: Principles, pitfalls 1696 and (pre-) clinical progress, J Control Release, vol.161, pp.175-87, 2012.

K. R. Lattwein, H. Shekhar, J. Kouijzer, W. Van-wamel, C. K. Holland et al.,

, Sonobactericide: An emerging treatment strategy for bacterial infections, 1699.

, Med Biol, 2019.

K. R. Lattwein, H. Shekhar, W. Van-wamel, T. Gonzalez, A. B. Herr et al.,

, An in vitro proof-of-principle study of sonobactericide, Sci Rep, vol.8, p.3411, 2018.

H. Lea-banks, O. 'reilly, M. A. Hynynen, and K. , Ultrasound-responsive droplets for therapy: A 1703 review, J Control Release, vol.293, pp.144-54, 2019.

H. Lea-banks, B. Teo, E. Stride, and C. C. Coussios, The effect of particle density on ultrasound-1705 mediated transport of nanoparticles, Phys Med Biol, vol.61, pp.7906-7924, 2016.

K. A. Lee, A. Cha, M. H. Kumar, C. Rezayat, and C. M. Sales, Catheter-directed, ultrasound-assisted 1707 thrombolysis is a safe and effective treatment for pulmonary embolism, even in high-risk 1708 patients, cardiomyopathy by reducing apoptosis and fibrosis, vol.5, pp.423-456, 2014.

G. Leinenga and J. Götz, Scanning ultrasound removes amyloid-? and restores memory in an 1713

, Alzheimer's disease mouse model, Sci Transl Med, vol.7, pp.278-311, 2015.

I. Lentacker, D. Cock, I. Deckers, R. , D. Smedt et al., Understanding ultrasound 1715 induced sonoporation: definitions and underlying mechanisms, Adv Drug Deliv Rev, vol.1716, pp.49-64, 2014.

I. Lentacker, D. Smedt, S. C. Sanders, and N. N. , Drug loaded microbubble design for ultrasound 1718 triggered delivery, Soft Matter, vol.5, pp.2161-70, 2009.

R. S. Leow, J. M. Wan, and A. C. Yu, Membrane blebbing as a recovery manoeuvre in site-specific 1720 sonoporation mediated by targeted microbubbles, J R Soc Interface, vol.12, 2015.

S. Li, C. Zhu, S. Fang, W. Zhang, N. He et al., Ultrasound microbubbles 1722 enhance human beta-defensin 3 against biofilms, J Surg Res, vol.199, pp.458-69, 2015.

W. Li, T. Yuan, G. Xia-sheng, X. Di, and Z. Dong, Microstreaming velocity field and shear stress 1724 created by an oscillating encapsulated microbubble near a cell membrane, Chin Phys B, vol.1725, p.124302, 2014.

A. H. Liao, C. R. Hung, C. F. Lin, Y. C. Lin, and H. K. Chen, Treatment effects of lysozyme-shelled 1727 microbubbles and ultrasound in inflammatory skin disease, Sci Rep, vol.7, p.41325, 2017.

T. Lin, X. Z. Cai, M. M. Shi, Z. M. Ying, B. Hu et al., In vitro and 1729 in vivo evaluation of vancomycin-loaded PMMA cement in combination with ultrasound 1730 and microbubbles-mediated ultrasound, Biomed Res Int, p.309739, 2015.

N. Lipsman, Y. Meng, A. J. Bethune, Y. Huang, B. Lam et al.,

I. , B. A. Smith, G. S. Hynynen, K. Black, and S. E. , Blood-brain barrier opening in Alzheimer's 1733 disease using MR-guided focused ultrasound, IEEE Ultrasonics Symposium Proceedings. Japan, vol.9, p.2336, 2018.

H. L. Liu, H. Y. Hsieh, L. A. Lu, C. W. Kang, M. F. Wu et al., Low-pressure pulsed focused 1738 ultrasound with microbubbles promotes an anticancer immunological response, J Transl 1739 Med, vol.10, p.221, 2012.

J. X. Liu, F. F. Xu, J. Huang, J. S. Xu, Y. Liu et al., , p.1741

Z. G. Wang and P. Li, Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a 1742 theranostic agent for noninvasive cancer molecular imaging and drug delivery, Biomater 1743 Sci, vol.6, 2018.

Y. Liu, L. Li, Q. Su, T. Liu, Z. Ma et al., Ultrasound-Targeted Microbubble Destruction 1745

, Enhances Gene Expression of microRNA-21 in Swine Heart via Intracoronary Delivery

, Echocardiography, vol.32, pp.1407-1423, 2015.

D. M. Long, F. K. Multer, A. G. Greenburg, G. W. Peskin, E. C. Lasser et al.,

, Tumor imaging with x-rays using macrophage uptake of radiopaque fluorocarbon 1749 emulsions, Surgery, vol.84, pp.104-116, 1978.

. Lumason®, US Food and Drug Administration, 2016.

W. X. Luo, G. Wen, L. Yang, J. Tang, J. G. Wang et al., , p.1752

Y. Wang and Y. J. Li, Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble

, Complex with Ultrasound for Tumor Treatment, Theranostics, vol.7, pp.452-65, 2017.

S. I. Madanshetty, R. A. Roy, and R. E. Apfel, Acoustic Microcavitation -Its Active and Passive 1755

, Acoustic Detection, J Acoust Soc Am, vol.90, pp.1515-1541, 1991.

H. Maeda, Macromolecular therapeutics in cancer treatment: The EPR effect and beyond, Feasibility Study. Sci Rep, vol.164, p.321, 2012.

V. H. Man, P. M. Truong, M. S. Li, J. Wang, N. T. Van-oanh et al., Molecular 1763 Mechanism of the Cell Membrane Pore Formation Induced by Bubble Stable Cavitation, Journal of Physical Chemistry B, vol.123, pp.71-78, 1764.

N. Maria, S. R. Barnes, M. R. Weist, D. Colcher, A. A. Raubitschek et al., Low dose focused 1766 ultrasound induces enhanced tumor accumulation of natural killer cells, PLoS One, vol.10, 1767.

P. Marmottant and S. Hilgenfeldt, Controlled vesicle deformation and lysis by single oscillating 1769 bubbles, Nature, vol.423, pp.153-159, 2003.

B. Marty, B. Larrat, M. Van-landeghem, C. Robic, P. Robert et al., , p.1771

M. Tanter, F. Lethimonnier, and S. Meriaux, Dynamic study of blood-brain barrier closure after 1772 its disruption using ultrasound: a quantitative analysis, J Cereb Blood Flow Metab, vol.1773, pp.1948-58, 2012.

W. Mathias, J. M. Tsutsui, B. G. Tavares, A. M. Fava, and M. Aguiar,

A. Nicolau, J. C. Ribeiro, H. B. Chiang, H. P. Sbano, J. Morad et al.,

L. Ce, . Bbc, J. Ramirez, K. R. Porter, T. R. Investigators et al., Sonothrombolysis 1777 in ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous 1778

, Coronary Intervention. J Am Coll Cardiol, vol.73, pp.2832-2874, 2019.

W. Mathias, J. M. Tsutsui, B. G. Tavares, F. Xie, M. Aguiar et al., , p.1780

J. C. Nicolau, P. Neto, C. E. Rochitte, J. Ramires, K. R. Porter et al., Diagnostic 1781

, Ultrasound Impulses Improve Microvascular Flow in Patients With STEMI Receiving 1782

, Intravenous Microbubbles. J Am Coll Cardiol, vol.67, pp.2506-2521, 2016.

, Using Pulsed Ultrasound Cavitation Therapy -Histotripsy, Ultrasound Med Biol, vol.1785, pp.1982-94, 2009.

N. Mcdannold, C. D. Arvanitis, N. Vykhodtseva, and M. S. Livingstone, Temporary disruption of the 1787 blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation 1788 in rhesus macaques, Cancer Res, vol.72, pp.3652-63, 2012.

N. Mcdannold, N. Vykhodtseva, and K. Hynynen, Targeted disruption of the blood-brain barrier 1790 with focused ultrasound: association with cavitation activity, Phys Med Biol, vol.1791, pp.793-807, 2006.

C. Mcewan, S. Kamila, J. Owen, H. Nesbitt, B. Callan et al., , p.1793

M. A. Taylor, E. Stride, A. P. Mchale, and J. F. Callan, Combined sonodynamic and antimetabolite 1794 therapy for the improved treatment of pancreatic cancer using oxygen loaded 1795 microbubbles as a delivery vehicle, Biomaterials, vol.80, pp.20-32, 2016.

C. Mcewan, J. Owen, E. Stride, C. Fowley, H. Nesbitt et al., , p.1797

N. Nomikou, A. P. Mchale, and J. F. Callan, Oxygen carrying microbubbles for enhanced 1798 sonodynamic therapy of hypoxic tumours, J Control Release, vol.203, pp.51-57, 2015.

D. Mcmahon and K. Hynynen, Acute Inflammatory Response Following Increased Blood-Brain

, Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

, Theranostics, vol.7, pp.3989-4000, 2017.

D. Mcmahon, E. Mah, and K. Hynynen, Angiogenic response of rat hippocampal vasculature to 1803 focused ultrasound-mediated increases in blood-brain barrier permeability, Sci Rep, vol.1804, p.12178, 2018.

B. P. Mead, N. Kim, G. W. Miller, D. Hodges, P. Mastorakos et al., , p.1806

J. S. Suk, J. Hanes, R. J. Price, P. Mastorakos, J. S. Suk et al., Targeted gene transfer to 1810 the brain via the delivery of brain-penetrating DNA nanoparticles with focused 1811 ultrasound, J Control Release, vol.223, pp.109-126, 2016.

G. Mehta, A. Y. Hsiao, M. Ingram, G. D. Luker, and S. Takayama, Opportunities and challenges for use 1813 of tumor spheroids as models to test drug delivery and efficacy, J Control Release, vol.1814, pp.192-204, 2012.

H. S. Min, S. Son, D. G. You, T. W. Lee, J. Lee et al., , p.1816

K. Choi, K. Park, K. Kim, and I. C. Kwon, Chemical gas-generating nanoparticles for tumor-1817 targeted ultrasound imaging and ultrasound-triggered drug delivery, Biomaterials, vol.1818, pp.57-70, 2016.

C. A. Molina, M. Ribo, M. Rubiera, J. Montaner, E. Santamarina et al., Microbubble administration 1821 accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients 1822 treated with intravenous tissue plasminogen activator, Stroke, vol.37, pp.425-434, 2006.

S. Monteith, J. Sheehan, R. Medel, M. Wintermark, M. Eames et al.,

, Potential intracranial applications of magnetic resonance-guided focused ultrasound 1825 surgery, J Neurosurg, vol.118, pp.215-236, 2013.

A. S. Montero, F. Bielle, L. Goldwirt, A. Lalot, G. Bouchoux et al., , p.1827

P. F. Pradat, F. Salachas, S. Boillée, C. Lobsiger, C. Lafon et al.,

, Ultrasound-Induced Blood-Spinal Cord Barrier Opening in Rabbits, Ultrasound Med, vol.45, pp.2417-2443, 1829.

, Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability, PLoS One, vol.1832, p.159892, 2016.

R. Myers, C. Coviello, P. Erbs, J. Foloppe, C. Rowe et al., Polymeric Cups for Cavitation-mediated Delivery 1835 of Oncolytic Vaccinia Virus, Mol Ther, vol.24, pp.1627-1660, 2016.

C. F. Naudé and A. T. Ellis, On the Mechanism of Cavitation Damage by Nonhemispherical Cavities 1837

, Collapsing in Contact With a Solid Boundary, J Basic Eng, vol.83, pp.648-56, 1961.

H. Nesbitt, Y. Sheng, K. S. Logan, K. Thomas, K. Callan et al.,

D. , K. P. Beguin, E. Stride, E. Mchale, A. P. Callan et al., Gemcitabine loaded microbubbles 1840 for targeted chemo-sonodynamic therapy of pancreatic cancer, J Control Release, vol.1841, pp.8-16, 2018.

C. P. Nolsøe and T. Lorentzen, International guidelines for contrast-enhanced ultrasonography: 1843 ultrasound imaging in the new millennium, Ultrasonography, vol.35, pp.89-103, 2016.

A. N. Nowbar, M. Gitto, J. P. Howard, D. P. Francis, and R. Al-lamee,

, Disease Analysis of Data From the World Health Organization and Coronary Artery 1846

, Disease Risk Factors From NCD Risk Factor Collaboration, vol.12, 1847.

W. L. Nyborg, Acoustic Streaming near a Boundary, J Acoust Soc Am, vol.30, pp.329-368, 1958.

M. A. O'reilly, T. Chinnery, M. L. Yee, S. K. Wu, K. Hynynen et al.,

. Ki, Preliminary Investigation of Focused Ultrasound-Facilitated Drug

, Delivery for the Treatment of Leptomeningeal Metastases. Sci Rep, vol.8, p.9013, 2018.

M. A. O'reilly and K. Hynynen, Blood-brain barrier: real-time feedback-controlled focused 1853 ultrasound disruption by using an acoustic emissions-based controller, Radiology, vol.1854, pp.96-106, 2012.

M. A. O'reilly, R. M. Jones, and K. Hynynen, Three-dimensional transcranial ultrasound imaging of 1856 microbubble clouds using a sparse hemispherical array, IEEE Trans Biomed Eng, vol.1857, pp.1285-94, 2014.

T. M. Optison, US Food and Drug Administration, 2012.

V. Paefgen, D. Doleschel, and F. Kiessling, Evolution of contrast agents for ultrasound imaging and 1860 ultrasound-mediated drug delivery, Front Pharmacol, vol.6, p.197, 2015.

R. Pandit, G. Leinenga, and J. Götz, Repeated ultrasound treatment of tau transgenic mice clears 1862 neuronal tau by autophagy and improves behavioral functions, Theranostics, vol.1863, pp.3754-67, 2019.

W. M. Pardridge, The blood-brain barrier: bottleneck in brain drug development, NeuroRx, vol.1865, pp.3-14, 2005.

J. L. Paris, C. Mannaris, M. V. Cabanas, R. Carlisle, M. Manzano et al.,

, Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica 1868 nanoparticles for controlled-release drug delivery, Chem Eng J, vol.340, pp.2-8, 2018.

E. J. Park, Y. Z. Zhang, N. Vykhodtseva, and N. Mcdannold, Ultrasound-mediated blood-brain/blood-1870 tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain 1871 metastasis model, J Control Release, vol.163, pp.277-84, 2012.

Y. C. Park, C. Zhang, S. Kim, G. Mohamedi, C. Beigie et al., Jeon 1873 NL, Wong JY. Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug

. Delivery, ACS Appl Mater Interfaces, vol.8, pp.31541-31590, 2016.

A. H. Payne, G. W. Hawryluk, Y. Anzai, H. Odéen, M. A. Ostlie et al.,

S. and C. Dj, Magnetic resonance imaging-guided focused ultrasound to increase 1877 localized blood-spinal cord barrier permeability, Neural Regen Res, vol.12, pp.2045-2094, 2017.

, Sonothrombolysis: the contribution of stable and inertial cavitation to clot lysis

, Ultrasound Med Biol, vol.41, pp.1402-1412, 2015.

A. D. Phelps and T. G. Leighton, The subharmonic oscillations and combination-frequency 1883 subharmonic emissions from a resonant bubble: Their properties and generation 1884 mechanisms, Acustica, vol.83, pp.59-66, 1997.

C. T. Poon, K. Shah, C. Lin, R. Tse, K. K. Kim et al.,

, Time course of focused ultrasound effects on ?-amyloid plaque pathology in the

, TgCRND8 mouse model of Alzheimer's disease, Sci Rep, vol.8, p.14061, 2018.

A. N. Pouliopoulos and J. J. Choi, Superharmonic microbubble Doppler effect in ultrasound therapy

, Phys Med Biol, vol.61, pp.6154-71, 2016.

A. F. Prokop, A. Soltani, and R. A. Roy, Cavitational mechanisms in ultrasound-accelerated 1891 fibrinolysis, Ultrasound Med Biol, vol.33, pp.924-957, 2007.

A. Prosperetti, Thermal Effects and Damping Mechanisms in Forced Radial Oscillations of

, Gas-Bubbles in Liquids, J Acoust Soc Am, vol.61, pp.17-27, 1977.

L. Qian, B. Thapa, J. Hong, Y. Zhang, M. Zhu et al., The present and future role 1895 of ultrasound targeted microbubble destruction in preclinical studies of cardiac gene 1896 therapy, J Thorac Dis, vol.10, pp.1099-111, 2018.

D. Qin, L. Zhang, N. Chang, P. Ni, Y. Zong et al., In situ observation of 1898 single cell response to acoustic droplet vaporization: Membrane deformation, 1899 permeabilization, and blebbing, Ultrason Sonochem, vol.47, pp.141-50, 2018.

P. Qin, T. Han, A. Yu, and L. Xu, Mechanistic understanding the bioeffects of ultrasound-driven 1901 microbubbles to enhance macromolecule delivery, J Control Release, vol.272, pp.169-81, 2018.

K. Radhakrishnan, C. K. Holland, and K. J. Haworth, Scavenging dissolved oxygen via acoustic droplet 1903 vaporization, Ultrason Sonochem, vol.31, pp.268-76, 1906.

E. Ronan, N. Edjiu, O. Kroukamp, G. Wolfaardt, and R. Karshafian, USMB-induced synergistic 1908 enhancement of aminoglycoside antibiotics in biofilms, Ultrasonics, vol.69, pp.182-90, 2016.

S. Roovers, G. Lajoinie, D. Cock, I. Brans, T. Dewitte et al., , 1910.

L. I. Sc, Sonoprinting of nanoparticle-loaded microbubbles: Unraveling the 1911 multi-timescale mechanism, Biomaterials, vol.217, p.119250, 2019.

S. Roovers, G. Lajoinie, J. Prakash, M. Versluis, D. Smedt et al., Liposome-loaded 1913 microbubbles and ultrasound enhance drug delivery in a 3D tumor spheroid, Abstract 1914 book 24th Eur Symp Ultrasound Contrast Imaging, 2019.

S. Roovers, T. Segers, G. Lajoinie, J. Deprez, M. Versluis et al., The Role 1916 of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble 1917 Fundamentals to Clinical Translation, Langmuir, 2019.

I. Rosenthal, J. Z. Sostaric, and P. Riesz, Sonodynamic therapy-a review of the synergistic effects of 1919 drugs and ultrasound, Ultrason Sonochem, vol.11, pp.349-63, 2004.

S. Rossi, C. Szíjjártó, F. Gerber, G. Waton, and M. P. Krafft, Fluorous materials in microbubble 1921 engineering science and technology-Design and development of new bubble 1922 preparation and sizing technologies, J Fluorine Chem, vol.132, pp.1102-1111, 2011.

C. F. Rowlatt and S. J. Lind, Bubble collapse near a fluid-fluid interface using the spectral element 1924 marker particle method with applications in bioengineering, Int J Multiphas Flow, vol.90, pp.118-161, 1925.

R. A. Roy, S. I. Madanshetty, and R. E. Apfel, An Acoustic Backscattering Technique for the Detection 1927 of Transient Cavitation Produced by Microsecond Pulses of Ultrasound, J Acoust Soc Am, vol.87, pp.3071-83, 1928.

P. M. Santos and L. H. Butterfield, Dendritic Cell-Based Cancer Vaccines, J Immunol, vol.200, pp.443-1932, 2018.

T. Scarcelli, J. F. Jordão, M. A. O'reilly, N. Ellens, K. Hynynen et al., Stimulation of 1934 hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult 1935 mice, Brain Stimul, vol.7, pp.304-311, 2014.

A. J. Schissler, R. J. Gylnn, P. S. Sobieszczyk, and A. B. Waxman, Ultrasound-assisted catheter-directed 1937 thrombolysis compared with anticoagulation alone for treatment of intermediate-risk 1938 pulmonary embolism, Pulmonary Circulation, vol.8, 2018.

M. Schneider, B. Anantharam, M. Arditi, D. Bokor, A. Broillet et al., , 1940.

I. Tardy, J. Terrettaz, R. Senior, and F. Tranquart, New Ultrasound Blood Pool Agent, vol.38

, Invest Radiol, vol.46, pp.486-94, 2011.

A. R. Sever, P. Mills, S. E. Jones, W. Mali, and P. A. Jones, Sentinel node identification using 1943 microbubbles and contrast-enhanced ultrasonography, Clin Radiol, vol.67, pp.687-94, 2012.

A. R. Sever, P. Mills, J. Weeks, S. E. Jones, D. Fish et al., Preoperative needle biopsy 1945 of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced 1946 ultrasound in patients with breast cancer, AJR Am J Roentgenol, vol.199, pp.465-70, 2012.

F. E. Shamout, A. N. Pouliopoulos, P. Lee, S. Bonaccorsi, L. Towhidi et al.,

, Enhancement of non-invasive trans-membrane drug delivery using ultrasound and 1949 microbubbles during physiologically relevant flow, Ultrasound Med Biol, vol.41, pp.2435-1950, 2015.

P. S. Sheeran and P. A. Dayton, more active vesicular transport of blood-borne tracer molecules than capillaries and 1955 venules after focused ultrasound-evoked opening of the blood-brain barrier, Curr Pharm, vol.18, pp.2152-65, 1952.

, Med Biol, vol.32, pp.1399-409, 2006.

N. Sheikov, N. Mcdannold, S. Sharma, and K. Hynynen, Effect of focused ultrasound applied with 1958 an ultrasound contrast agent on the tight junctional integrity of the brain microvascular 1959 endothelium, Ultrasound Med Biol, vol.34, pp.1093-104, 2008.

N. Sheikov, N. Mcdannold, N. Vykhodtseva, F. Jolesz, and K. Hynynen, Cellular mechanisms of the 1961 blood-brain barrier opening induced by ultrasound in presence of microbubbles

, Ultrasound Med Biol, vol.30, pp.979-89, 2004.

H. Shekhar, K. B. Bader, S. W. Huang, T. Peng, S. L. Huang et al., In vitro 1964 thrombolytic efficacy of echogenic liposomes loaded with tissue plasminogen activator 1965 and octafluoropropane gas, Phys Med Biol, vol.62, pp.517-555, 2017.

H. Shekhar, R. T. Kleven, T. Peng, A. Palaniappan, K. B. Karani et al., , 1967.

C. K. Holland, In vitro characterization of sonothrombolysis and echocontrast agents to 1968 treat ischemic stroke, Sci Rep, vol.9, 2019.

W. H. Shentu, C. X. Yan, C. M. Liu, R. X. Qi, Y. Wang et al., Use of 1970 cationic microbubbles targeted to P-selectin to improve ultrasound-mediated gene 1971 transfection of hVEGF165 to the ischemic myocardium, J Zhejiang Univ Sci B, vol.19, pp.699-707, 1972.

Y. D. Shi, W. Y. Shi, L. Chen, and J. P. Gu, A systematic review of ultrasound-accelerated catheter-1974 directed thrombolysis in the treatment of deep vein thrombosis, J Thromb Thrombolysis, vol.45, pp.440-51, 1975.

O. Shpak, M. Verweij, J. N. De, M. Versluis, and . Droplets, Bubbles and Ultrasound Interactions

, is initiated by superharmonic focusing, Proc Natl Acad Sci U S A, vol.880, pp.1697-702, 2014.

J. Silburt, N. Lipsman, and A. I. , Disrupting the blood-brain barrier with focused ultrasound: 1981 Perspectives on inflammation and regeneration, Proc Natl Acad Sci, 2017.

M. T. Silvestrini, E. S. Ingham, L. M. Mahakian, A. Kheirolomoom, Y. Liu et al.,

. St, K. D. Watson, A. W. Wong, A. M. Monjazeb, N. E. Hubbard et al., , 1984.

K. W. Ferrara, Priming is key to effective incorporation of image-guided thermal ablation 1985 into immunotherapy protocols, JCI insight, vol.2, p.90521, 2017.

J. Slikkerveer, L. Juffermans, N. Van-royen, Y. Appelman, T. R. Porter et al., Therapeutic 1987 application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary 1988 thrombosis and microvascular obstruction, Eur Heart J Acute Cardiovasc Care, vol.8, pp.45-53, 1989.

S. Snipstad, S. Berg, Y. Morch, A. Bjorkoy, E. Sulheim et al., , 1991.

A. F. Maaland, S. H. Torp, and C. De-lange-davies, Ultrasound Improves the Delivery and 1992

, Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer, 1993.

. Xenografts, Ultrasound Med Biol, vol.43, pp.2651-69, 2017.

P. Sontum, S. Kvale, A. J. Healey, R. Skurtveit, R. Watanabe et al., Cluster Therapy (ACT)--A novel concept for ultrasound mediated, targeted drug 1996 delivery, Int J Pharm, vol.495, pp.1019-1046, 1995.

N. S. Sta-maria, S. R. Barnes, M. R. Weist, D. Colcher, A. A. Raubitschek et al., , 1998.

, Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells

, PLoS One, vol.10, p.142767, 2015.

R. M. Steinman, G. Kaplan, M. D. Witmer, and Z. A. Cohn, Identification of a novel cell type in 2001 peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface 2002 markers, and maintenance in vitro, J Exp Med, vol.149, pp.1-16, 1979.

E. Stride, G. Lajoinie, M. Borden, M. Versluis, S. Cherkaoui et al., Microbubble 2004 agents: New Directions, Ultrasound Med Biol, 2019.

Q. Su, L. Li, Y. Liu, Y. Zhou, J. Wang et al., Ultrasound-targeted microbubble destruction-2006 mediated microRNA-21 transfection regulated PDCD4/NF-kappaB/TNF-alpha pathway 2007 to prevent coronary microembolization-induced cardiac dysfunction, Gene Ther, vol.22, pp.1000-1006, 2008.

M. G. Sugiyama, V. Mintsopoulos, H. Raheel, N. M. Goldenberg, J. E. Batt et al.,

W. M. Leong-poi, H. Karshafian, R. Lee, and W. L. , Lung Ultrasound and Microbubbles Enhance, 2011.

, Aminoglycoside Efficacy and Delivery to the Lung in Escherichia

, Pneumonia and Acute Respiratory Distress Syndrome, Am J Respir Crit Care Med, vol.198, pp.404-412, 2013.

T. Sun, Y. Zhang, C. Power, P. M. Alexander, J. T. Sutton et al., , 2015.

N. J. Mcdannold, Closed-loop control of targeted ultrasound drug delivery across the 2016 blood-brain/tumor barriers in a rat glioma model, Proc Natl Acad Sci, vol.114, pp.10281-90, 2017.

J. T. Sutton, K. J. Haworth, G. Pyne-geithman, and C. K. Holland, Ultrasound-mediated drug delivery 2019 for cardiovascular disease, Expert Opin Drug Deliv, vol.10, pp.573-92, 2013.

J. T. Sutton, J. L. Raymond, M. C. Verleye, G. J. Pyne-geithman, and C. K. Holland, Pulsed ultrasound 2021 enhances the delivery of nitric oxide from bubble liposomes to ex vivo porcine carotid 2022 tissue, Int J Nanomedicine, vol.9, pp.4671-83, 2014.

K. Tachibana and S. Tachibana, Albumin microbubble echo-contrast material as an enhancer for 2024 ultrasound accelerated thrombolysis, Circulation, vol.92, pp.1148-50, 1995.

B. Theek, M. Baues, T. Ojha, D. Mockel, S. K. Veettil et al.,

F. and L. T. , Sonoporation enhances liposome accumulation and penetration in tumors 2027 with low EPR, J Control Release, vol.231, pp.77-85, 2016.

E. Thevenot, J. F. Jordao, M. A. O'reilly, K. Markham, Y. Q. Weng et al.,

K. and A. I. , Targeted delivery of self-complementary adeno-associated virus serotype 9 2030 to the brain, using magnetic resonance imaging-guided focused ultrasound, Hum Gene, vol.23, pp.1144-55, 2012.

X. Q. Tian, X. W. Ni, H. L. Xu, L. Zheng, D. L. Zhuge et al., Prevention 2033 of doxorubicin-induced cardiomyopathy using targeted MaFGF mediated by 2034 nanoparticles combined with ultrasound-targeted MB destruction, Int J Nanomedicine, vol.12, pp.7103-7122, 2017.

D. Trachootham, J. Alexandre, and P. Huang, Targeting cancer cells by ROS-mediated mechanisms: 2037 a radical therapeutic approach?, Nat Rev Drug Discov, vol.8, pp.579-91, 2009.

C. H. Tsai, J. W. Zhang, Y. Y. Liao, and H. L. Liu, Real-time monitoring of focused ultrasound blood-2039 brain barrier opening via subharmonic acoustic emission detection: implementation of 2040 confocal dual-frequency piezoelectric transducers, Phys Med Biol, vol.61, pp.2926-2972, 2016.

Y. S. Tung, F. Vlachos, J. J. Choi, T. Deffieux, K. Selert et al., In vivo transcranial 2042 cavitation threshold detection during ultrasound-induced blood-brain barrier opening in 2043 mice, Phys Med Biol, vol.55, pp.6141-55, 2010.

J. Unga and M. Hashida, Ultrasound induced cancer immunotherapy, Adv Drug Deliv Rev, vol.2045, pp.144-53, 2014.

T. Van-rooij, I. Skachkov, I. Beekers, K. R. Lattwein, J. D. Voorneveld et al.,

Y. , V. Der-steen, A. F. De-jong, N. Kooiman, and K. , Viability of endothelial cells after 2048 ultrasound-mediated sonoporation: Influence of targeting, oscillation, and displacement 2049 of microbubbles, J Control Release, vol.238, pp.197-211, 2016.

A. Van-wamel, K. Kooiman, M. Harteveld, M. Emmer, F. J. Ten-cate et al.,

, Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation

, J Control Release, vol.112, pp.149-55, 2006.

A. Van-wamel, P. C. Sontum, A. Healey, S. Kvale, N. Bush et al., Acoustic Cluster, 2054.

, ACT) enhances the therapeutic efficacy of paclitaxel and Abraxane (R) for 2055 treatment of human prostate adenocarcinoma in mice, J Control Release, vol.236, pp.15-2056, 2016.

F. Vignon, W. T. Shi, J. E. Powers, E. C. Everbach, J. J. Liu et al., , 2058.

, Cavitation Imaging, IEEE Trans Ultrason Ferroelectr Freq Control, vol.60, pp.661-70, 2013.

, VisualSonics. PN11691 -Vevo MicroMarker TM Non-Targeted Contrast Agent Kit: Protocol 2060 and Information Booklet Rev 1.4, 2016.

J. Wachsmuth, R. Chopr, and K. Hynynen, Feasibility of transient image-guided blood-spinal 2062 cord barrier disruption, AIP Conference Proceedings, pp.256-59, 2009.

J. F. Wang, Z. L. Zhao, S. X. Shen, C. X. Zhang, S. C. Guo et al., Bin 2064 JP. Selective depletion of tumor neovasculature by microbubble destruction with 2065 appropriate ultrasound pressure, Int J Cancer, vol.137, pp.2478-91, 2015.

S. Wang, O. O. Olumolade, T. Sun, G. Samiotaki, and E. E. Konofagou, Noninvasive, neuron-specific 2067 gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated 2068 virus, Gene Ther, vol.22, pp.104-114, 2015.

S. Y. Wang, C. Y. Wang, S. Unnikrishnan, A. L. Klibanov, J. A. Hossack et al., Optical 2070 Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels, 2071.

, With In Vivo Results. Invest Radiol, vol.50, pp.772-84, 2015.

T. Y. Wang, J. W. Choe, K. Pu, R. Devulapally, S. Bachawal et al.,

R. , T. L. Khuri-yakub, B. Rao, J. Paulmurugan, R. Willmann et al., Ultrasound-guided 2074 delivery of microRNA loaded nanoparticles into cancer, J Control Release, vol.203, pp.99-2075, 2015.

Y. Wang, Y. Li, K. Yan, L. Shen, W. Yang et al., Clinical study of ultrasound and 2077 microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in 2078 digestive system, Chin J Cancer Res, vol.30, pp.553-63, 2018.

D. Weber-adrian, E. Thévenot, M. A. O'reilly, W. Oakden, M. K. Akens et al.,

K. Coultes, A. Burgess, J. Finkelstein, A. J. Yee, C. M. Whyne et al., Gene delivery to the spinal cord using MRI-guided 2082 focused ultrasound, Gene Ther, vol.22, pp.568-77, 2015.

J. S. Weber, American Society of Clinical Oncology 2084 educational book, Annual Meeting, vol.37, pp.205-214, 2017.

Y. L. Wei, N. Shang, J. H. He, Y. Pan, Y. W. Xiao et al.,

, Penetration of different molecule sizes upon ultrasound combined with microbubbles in 2088 a superficial tumour model, J Drug Target, 2019.

H. L. Weiss, P. Selvaraj, K. Okita, Y. Matsumoto, A. Voie et al., Mechanical clot 2090 damage from cavitation during sonothrombolysis, J Acoust Soc Am, vol.133, pp.3159-75, 2013.

G. Weller, F. S. Villanueva, A. L. Klibanov, and W. R. Wagner, Modulating targeted adhesion of an 2092 ultrasound contrast agent to dysfunctional endothelium, Ann Biomed Eng, vol.30, pp.1012-2093, 2002.

W. Wiedemair, Z. Tukovic, H. Jasak, D. Poulikakos, and V. Kurtcuoglu, The breakup of intravascular 2095 microbubbles and its impact on the endothelium, Biomech Model Mechanobiol, vol.16, pp.611-635, 2017.

C. C. Winterbourn, Reconciling the chemistry and biology of reactive oxygen species, Nat Chem, vol.4, pp.278-86, 2008.

J. Wu, Theoretical study on shear stress generated by microstreaming surrounding contrast 2100 agents attached to living cells, Ultrasound Med Biol, vol.28, pp.125-134, 2002.

P. A. Dayton and E. E. Konofagou, Focused ultrasound-facilitated brain drug delivery using 2103 optimized nanodroplets: vaporization efficiency dictates large molecular delivery

, Med Biol, vol.63, p.35002, 2018.

K. Xhima, F. Nabbouh, K. Hynynen, A. I. Tandon, and A. , Noninvasive delivery of an ?-synuclein 2106 gene silencing vector with magnetic resonance-guided focused ultrasound, Mov Disord, vol.2107, pp.1567-79, 2018.

N. Xiao, J. Liu, L. Liao, J. Sun, J. W. Shu et al., Ultrasound Combined With Microbubbles Increase 2109 the Delivery of Doxorubicin by Reducing the Interstitial Fluid Pressure, Ultrasound Q, vol.2110, pp.103-112, 2019.

L. Xing, Q. Shi, K. Zheng, M. Shen, J. Ma et al., , p.2112

, Mediated Microbubble Destruction (UMMD) Facilitates the Delivery, pp.19-28

, Targeted and Paclitaxel Loaded mPEG-PLGA-PLL Nanoparticles in Pancreatic Cancer

, Theranostics, vol.6, pp.10-10, 2016.

R. Xu and O. Ma, A Spine-Specific Phased Array for Transvertebral Ultrasound Therapy, p.2116

, Design & Simulation, IEEE Trans Biomed Eng, 2019.

F. Yan, L. Li, Z. T. Deng, Q. F. Jin, J. J. Chen et al.,

, Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic 2119 drug delivery carriers, J Control Release, vol.166, pp.246-55, 2013.

P. Yan, K. J. Chen, J. Wu, L. Sun, H. W. Sung et al., The use of MMP2 antibody-2121 conjugated cationic microbubble to target the ischemic myocardium, enhance Timp3 2122 gene transfection and improve cardiac function, Biomaterials, vol.35, pp.1063-73, 2014.

C. Yang, M. Du, F. Yan, and Z. Chen, Focused Ultrasound Improves NK-92MI Cells Infiltration Into microbubble destruction improved the antiangiogenic effect of Endostar in triple-2127 negative breast carcinoma xenografts, J Cancer Res Clin Oncol, vol.145, pp.1191-200, 2019.

Y. Yang, X. Zhang, D. Ye, R. Laforest, J. Williamson et al., Cavitation dose painting 2129 for focused ultrasound-induced blood-brain barrier disruption, Sci Rep, vol.9, p.2840, 2019.

C. Yee, Adoptive T cell therapy: points to consider, Curr Opin Immunol, vol.51, pp.197-203, 2018.

P. T. Yemane, A. Aslund, K. G. Saeterbo, A. Bjorkoy, S. Snipstad et al.,

Y. Hansen, R. Angelsen, B. Davies, and C. D. , The effect of sonication on extravasation 2133 and distribution of nanoparticles and dextrans in tumor tissue imaged by multiphoton 2134 microscopy, IEEE International Ultrasonics Symposium. Japan, 2018.

S. Yi, G. Han, Y. Shang, C. Liu, D. Cui et al., Microbubble-mediated 2136 ultrasound promotes accumulation of bone marrow mesenchymal stem cell to the prostate 2137 for treating chronic bacterial prostatitis in rats, Sci Rep, vol.6, 2016.

F. Yu, X. Chen, A. C. Straub, and J. J. Pacella, The Role of Nitric Oxide during Sonoreperfusion of 2139

, Microvascular Obstruction, Theranostics, vol.7, pp.3527-3565, 2017.

H. Yu and S. Chen, A model to calculate microstreaming-shear stress generated by oscillating 2141 microbubbles on the cell membrane in sonoporation, Biomed Mater Eng, vol.24, pp.861-869, 2014.

H. Yu, Z. Lin, L. Xu, D. Liu, and Y. Shen, Theoretical study of microbubble dynamics in sonoporation

, Ultrasonics, vol.61, pp.136-180, 2015.

H. Yuan, H. Hu, J. Sun, M. Shi, H. Yu et al., , 2145.

, Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic 2146 Plaque in an APOE-deficient Mouse Model, In Vivo, vol.32, pp.1025-1057, 2018.

Y. Yuana, L. Jiang, B. Lammertink, P. Vader, R. Deckers et al., Moonen 2148 CT. Microbubbles-Assisted Ultrasound Triggers the Release of Extracellular Vesicles. High-Intensity Focused Ultrasound as an Emerging Therapy for Stroke: A Review, J 2153 Neuroimaging, vol.29, pp.5-13, 2019.

A. Zeghimi, J. M. Escoffre, and A. Bouakaz, Role of endocytosis in sonoporation-mediated membrane 2155 permeabilization and uptake of small molecules: a electron microscopy study, Phys Biol, vol.2156, p.66007, 2015.

L. Zhang, T. H. Yin, B. Li, R. Q. Zheng, C. Qiu et al., Size-Modulable 2158

, Nanoprobe for High-Performance Ultrasound Imaging and Drug Delivery against

, Cancer. ACS Nano, vol.12, pp.3449-60, 2018.

L. L. Zhang, Z. S. Zhang, M. Negahban, and A. Jerusalem, Molecular dynamics simulation of cell 2161 membrane pore sealing, Extreme Mech Lett, vol.27, pp.83-93, 2019.

M. Zhang, W. Z. Yu, X. T. Shen, Q. Xiang, J. Xu et al., Advanced Interfere Treatment of Diabetic Cardiomyopathy Rats by aFGF-Loaded

, Heparin-Modified Microbubbles and UTMD Technique, Cardiovasc Drugs Ther, vol.2165, pp.247-61, 2016.

X. Zhang, G. E. Owens, C. A. Cain, H. S. Gurm, J. Macoskey et al., Histotripsy Thrombolysis on 2167 Retracted Clots, Ultrasound Med Biol, vol.42, pp.1903-1921, 2016.

Y. Z. Zhao, X. Q. Tian, M. Zhang, L. Cai, A. Ru et al., , p.2169

S. Charkrabarti, X. K. Li, Q. Lin, W. Z. Yu, S. Ge et al., Functional and 2170 pathological improvements of the hearts in diabetes model by the combined therapy of 2171 bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction, J Control, vol.186, pp.22-31, 2014.

Y. Z. Zhao, M. Zhang, H. L. Wong, X. Q. Tian, L. Zheng et al., Prevent diabetic cardiomyopathy in diabetic rats by combined therapy 2175 of aFGF-loaded nanoparticles and ultrasound-targeted microbubble destruction 2176 technique, J Control Release, vol.223, pp.11-21, 2016.

H. Zhou, S. Fang, R. Kong, W. Zhang, K. Wu et al., Effect of low frequency 2178 ultrasound plus fluorescent composite carrier in the diagnosis and treatment of 2179 methicillin-resistant Staphylococcus aureus biofilm infection of bone joint implant, Int J, p.2180

, Clin Exp Med, vol.11, pp.799-805, 2018.

Y. Zhou, H. Gu, Y. Xu, F. Li, S. Kuang et al., , p.2182

Y. Zhao, W. Song, Q. Wang, and D. Wang, Targeted antiangiogenesis gene therapy using 2183 targeted cationic microbubbles conjugated with CD105 antibody compared with 2184 untargeted cationic and neutral microbubbles, Theranostics, vol.5, pp.399-417, 2015.

Y. F. Zhou, Application of acoustic droplet vaporization in ultrasound therapy, J Ther Ultrasound, vol.3, 2015.

H. X. Zhu, X. Z. Cai, Z. L. Shi, B. Hu, and S. G. Yan, Microbubble-mediated ultrasound enhances the lethal 2188 effect of gentamicin on planktonic Escherichia coli, Biomed Res Int, p.142168, 2014.

X. Zhu, J. Guo, C. He, H. Geng, G. Yu et al., Ultrasound triggered image-2190 guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded 2191 microbubbles, Sci Rep, vol.6, 2016.

, Figure 1. Combined effect of nonlinear propagation and focusing of the harmonics in a 2195 perfluoropentane micrometer-sized droplet, p.2196

, MHz and a focus at 3.81 cm, and the radius of the droplet is 10 µm for ease of observation

, The pressures are given on the axis of the droplet along the propagating direction of the 2198 ultrasound wave, and the shaded area indicates the location of the droplet (reprinted with 2199 permission from, 2014.