S. ;. , Berget and her lab members for generously providing us with Herschman, Annu. Rev. Biochem, vol.60, pp.281-319, 1991.

S. L. Hsuan, J. J. Totty, N. , J. , and R. J. , unr, NIH grant (GM 59211). A.-B. S. was the recipient of an American a cellular cytoplasmic RNA-binding protein with five cold-shock Heart Association Established Investigator Award. domains, is required for internal initiation of translation of human rhinovirus RNA, Genes Dev, vol.15, pp.437-438, 1999.

A. Jacobson, Poly(A) metabolism and translation: The closed-loop Model, pp.451-480, 1996.

H. Jacquemin-sablon, G. Triqueneaux, S. Deschamps, . Le-maire, N. Caruccio et al., 269, intracellular localization of unr, a protein with five cold shock do-31814-31821. mains, Nucleic Acids Res, vol.22, pp.2643-2650, 1994.

C. Y. Chen, A. B. Shyu, and E. Wahle, Poly(A) tail shortening by a mamresponse-gene mRNAs: functional analyses of sequence features malian poly(A)-specific 3?-exoribonuclease, Mol. Cell. Biol, vol.14, pp.8471-8482, 1994.

A. C. Chen, .. Shyu, and A. , Rapid c-myc degradation does not require ization and importance in mRNA degradation, Trends Biochem. Sci, vol.20, pp.2387-2394, 1991.

C. Y. Chen, Y. You, A. B. Shyu, C. A. Chen, and A. Shyu, Unraveling a bind specifically to a purine-rich sequence necessary for the destacytoplasmic role for hnRNP D in the in vivo mRNA destabilization bilization function of a c-fos protein-coding region determinant of directed by the AU-rich element, mRNA instability. Mol. Cell. Biol, vol.13, pp.5748-5757, 1992.

J. L. Manley, N. J. Proudfoot, T. M. Chen, and A. B. Shyu, functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function, Mol. Cell. Biol, vol.8, pp.3461-3470, 1994.

C. Y. Chen, N. Xu, A. B. Shyu, and M. W. Hentze, Dual function of the messenger RNA cap structure in poly(A)-tail-promoted translation in yeast. Naphage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation, Mol. Cell. Biol, vol.15, pp.516-520, 1995.

T. Preiss, M. W. Hentze, . Curr, . Opin, A. W. Craig et al., Inter-Dev. 9, 515-521. action of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation, Nature, vol.392, pp.520-523, 1998.

J. Ross, mRNA stability in mammalian cells, Microbiol. Rev, vol.59, pp.423-450, 1995.

G. Dreyfuss, M. J. Matunis, S. Pinol-roma, C. G. Burd, P. Sarnow et al., Starting at the 62, 289-321. beginning, middle, and end: translation initiation in eukaryotes, Annu. Rev. Biochem. Sachs, vol.89, pp.831-838, 1993.

P. Fort, L. Marty, M. Piechaczyk, S. E. Sabrouty, C. Dani et al., 1431-tein-coding region facilitate mRNA deadenylation and decay by a 1442. mechanism coupled to translation, Nucleic Acids Res, vol.13, pp.3441-3448, 1985.

D. R. Gallie, . .-;-a.-b, and M. F. Wilkinson, The double lives of shuttling to regulate mRNA translational efficiency, Genes Dev, vol.5, pp.135-138, 1991.

M. Gao, D. T. Fritz, L. P. Ford, J. Wilusz, A. Shyu et al., The c-fos between a poly(A)-specific ribonuclease and the 5? cap influences mRNA is targeted for rapid decay by two distinct mRNA degradation mRNA deadenylation rates in vitro, pathways. Genes Dev, vol.5, pp.60-72, 1989.

A. Shyu, J. G. Belasco, M. G. Greenberg, C. G. Burd, and G. Dreyfuss, The mRNA poly(A)-destabilizing elements in the c-fos message trigger deadenylation binding protein: localization, abundance, and RNA-binding specificas a first step in rapid mRNA decay, Two distinct Gö rlach, vol.5, pp.400-407, 1991.

A. Shyu, J. A. Garcia-sanz, and E. Mullner, Analysis, 1996.
URL : https://hal.archives-ouvertes.fr/hal-01341497

M. E. Greenberg and J. G. Belasco, Control of the decay of of mRNA decay in mammalian cells, 1993.

S. Z. Tarun, S. E. Wells, J. A. Deardorff, and A. B. Sachs, Translation initiation factor eIF4G mediates in vitro poly(A) taildependent translation, Control of Messenger RNA Stability, vol.94, pp.9046-9051, 1997.

C. E. Harris, R. A. Boden, C. R. Astell, M. Velten, P. Franzon et al., A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of Triqueneaux, J. Virol, vol.73, pp.72-80, 1999.

H. Sablon, RNA binding specificity of Unr, a protein with five cold shock domains, Nucleic Acids Res, vol.27, pp.1926-1934, 1999.

W. C. Hassfeld, D. A. Mathison, D. Portman, G. Dreyfuss, G. Steiner et al., The ribonucleoprotein R (hnRNP R) using autoimmune antibody: immudestabilizing elements in the coding region of c-fos mRNA are recognological relationship with hnRNP P, Nucleic Acids Res, vol.26, pp.5034-5042, 1993.

M. W. Hentze, A. E. Kulozik, P. E. Hillner, R. D. Vale, and A. B. Sachs, 307-310. ization of mRNA by eukaryotic translation initiation factors, Mol. Cell, vol.96, pp.135-140, 1998.

D. J. Herrick, J. Ross, R. Wisdom, and W. Lee, The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and untranslated regions and role of ribosome translocation, Mol. Cell. Biol, vol.14, pp.232-243, 1991.

J. M. Yeakley, J. P. Morfin, M. G. Rosenfeld, and X. D. Fu, A complex of nuclear proteins mediates SR protein binding to a purinerich splicing enhancer, Proc. Natl. Acad. Sci. USA, vol.93, pp.7582-7587, 1996.

N. M. Yeilding, W. N. Procopio, M. T. Rehman, and W. M. Lee, c-myc mRNA is down-regulated during myogenic differentiation by accelerated decay that depends on translation of regulatory coding elements, J. Biol. Chem, vol.273, pp.15749-15757, 1998.

T. J. Yen, P. S. Machlin, C. , and D. W. , Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin, Nature, vol.334, pp.580-585, 1988.

M. L. Zapp and S. M. Berget, Evidence for nuclear factors involved in recognition of 5? splice sites, Nucleic Acids Res, vol.17, pp.2655-2674, 1989.

S. Zhang, E. M. Welch, K. Hogan, A. H. Brown, S. W. Peltz et al., Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae, RNA, vol.3, pp.234-244, 1997.