Dynamics of demethylation and activation of the alpha-actin gene in myoblasts, Cell, vol.63, pp.1229-1266, 1990. ,
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain, Science, vol.324, pp.929-959, 2009. ,
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1, Science, vol.324, p.9305, 2009. ,
Petersen-Mahrt SK, 5-Methylcytosine DNA. demethylation: more than losing a methyl group, Annu Rev Genet, vol.46, pp.419-460, 2012. ,
Reprogramming towards pluripotency requires AID-dependent DNA demethylation, Nature, vol.463, pp.1042-1049, 2010. ,
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA, Science, vol.333, pp.1303-1310, 2011. ,
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism, Nat Commun, vol.7, p.10806, 2016. ,
Influence of metabolism on epigenetics and disease, Cell, vol.153, issue.1, pp.56-69, 2013. ,
Role of TET enzymes in DNA methylation, development, and cancer, Genes Dev, vol.30, pp.733-50, 2016. ,
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX, Nature, vol.497, pp.122-128, 2013. ,
Cytosine-based TET enzyme inhibitors, ACS Med Chem Lett, vol.10, pp.180-185, 2019. ,
The Prdm family: expanding roles in stem cells and development, Development, vol.139, pp.2267-82, 2012. ,
SET domains and histone methylation, Curr Opin Struct Biol, vol.13, pp.699-705, 2003. ,
The role of PRDMs in cancer: one family, two sides, Curr Opin Genet Dev, vol.36, pp.83-91, 2016. ,
Beating the odds: BETs in disease, Trends Biochem Sci, vol.40, pp.468-79, 2015. ,
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer, Nat Rev Mol Cell Biol, vol.18, pp.246-62, 2017. ,
A chemical toolbox for the study of bromodomains and epigenetic signaling, Nat Commun, vol.10, 1915. ,
Reading cancer Chromatin readers as druggable targets for cancer treatment, Cancers (Basel), vol.11, p.61, 2019. ,
Biological functions of methyl-CpG-binding proteins, Prog Mol Biol Transl Sci, vol.101, pp.377-98, 2011. ,
The methyl-CpG-binding protein MeCP2 and neurological disease, Biochem Soc Trans, vol.36, pp.575-83, 2008. ,
Readers of DNA methylation, the MBD family as potential therapeutic targets, Pharmacol Ther, vol.184, pp.98-111, 2018. ,
Bromodomain inhibitors and cancer therapy: from structures to applications, Epigenetics, vol.12, pp.323-362, 2017. ,
Multitarget drugs: an epigenetic epiphany, ChemMedChem, vol.11, pp.1227-1268, 2016. ,
Natural products and chemical biology tools: alternatives to target epigenetic mechanisms in cancers, Chemical Rec, vol.18, pp.1854-76, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02383679
Epigenetic polypharmacology: from combination therapy to multitargeted drugs, Clin Epigenetics, vol.8, p.105, 2016. ,
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy, Clin Epigenetics, vol.8, p.57, 2016. ,
Recent progress in histone demethylase inhibitors, J Med Chem, vol.59, pp.1308-1337, 2016. ,
,
Towards a molecular understanding of microRNAmediated gene silencing, Nat Rev Genet, vol.16, pp.421-454, 2015. ,
Regulation of microRNA function in animals, Nat Rev Mol Cell Biol, vol.20, pp.21-37, 2019. ,
Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model, Nucleic Acids Res, vol.40, pp.1356-65, 2012. ,
from microRNA sequences to function, Nucleic Acids Res, vol.47, pp.155-62, 2019. ,
,
, Genome Res, vol.27, pp.234-279, 2017.
MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting beta-catenin and Wnt signaling, Hepatol Commun, vol.1, pp.168-83, 2017. ,
New tumor suppressor microRNAs target glypican-3 in human liver cancer, Oncotarget, vol.8, pp.41211-41237, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01677287
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc Natl Acad Sci, vol.99, pp.15524-15553, 2002. ,
Phase I. study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors, Invest New Drugs, vol.35, pp.180-188, 2017. ,
Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study, Lancet Oncol, vol.18, pp.1386-96, 2017. ,