Skip to Main content Skip to Navigation

Contribution of ROS and metabolic status to neonatal and adult CD8 + T cell activation

Abstract : In neonatal T cells, a low response to infection contributes to a high incidence of morbidity and mortality of neonates. Here we have evaluated the impact of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species of adult and neonatal CD8+ T cells on their activation potential. We have also constructed a logical model connecting metabolism and ROS with T cell signaling. Our model indicates the interplay between antigen recognition, ROS and metabolic status in T cell responses. This model displays alternative stable states corresponding to different cell fates, i.e. quiescent, activated and anergic states, depending on ROS levels. Stochastic simulations with this model further indicate that differences in ROS status at the cell population level contribute to the lower activation rate of neonatal, compared to adult, CD8+ T cells upon TCR engagement. These results are relevant for neonatal health care. Our model can serve to analyze the impact of metabolic shift during cancer in which, similar to neonatal cells, a high glycolytic rate and low concentrations of glutamine and arginine promote tumor tolerance.
Complete list of metadatas

Cited literature [44 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02428783
Contributor : Myriam Bodescot <>
Submitted on : Monday, January 6, 2020 - 11:29:40 AM
Last modification on : Wednesday, March 25, 2020 - 2:40:07 PM

File

journal.pone.0226388.pdf
Publication funded by an institution

Identifiers

Collections

Citation

José Sánchez-Villanueva, Otoniel Rodríguez-Jorge, Oscar Ramirez-Pliego, Gabriela Rosas Salgado, Wassim Abou-Jaoudé, et al.. Contribution of ROS and metabolic status to neonatal and adult CD8 + T cell activation. PLoS ONE, Public Library of Science, 2019, 14 (12), pp.e0226388. ⟨10.1371/journal.pone.0226388⟩. ⟨inserm-02428783⟩

Share

Metrics

Record views

106

Files downloads

169