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Upregulation of PPARβ/δ Is Associated with Structural and Functional Changes in the Type I Diabetes Rat Diaphragm

Abstract : Background: Diabetes mellitus is associated with alterations in peripheral striated muscles and cardiomyopathy. We examined diaphragmatic function and fiber composition and identified the role of peroxisome proliferator-activated receptors (PPAR a and b/d) as a factor involved in diaphragm muscle plasticity in response to type I diabetes.
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Nadège Salvi, Aziz Guellich, Pierre Michelet, Alexandre Demoule, Morgan Le Guen, et al.. Upregulation of PPARβ/δ Is Associated with Structural and Functional Changes in the Type I Diabetes Rat Diaphragm. PLoS ONE, Public Library of Science, 2010, 5 (7), pp.e11494. ⟨10.1371/journal.pone.0011494⟩. ⟨inserm-02426556⟩

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