D. F. Quail and J. A. Joyce, Microenvironmental regulation of tumor progression and metastasis, Nat. Med, vol.19, pp.1423-1437, 2013.

D. Bock, K. Cauwenberghs, S. Carmeliet, and P. , Vessel abnormalization: Another hallmark of cancer? Molecular mechanisms and therapeutic implications, Curr. Opin. Genet. Dev, vol.21, pp.73-79, 2011.

A. S. Chung, J. Lee, and N. Ferrara, Targeting the tumour vasculature: Insights from physiological angiogenesis, Nat. Rev. Cancer, vol.10, pp.505-514, 2010.

R. K. Jain, Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy, Science, vol.307, pp.58-62, 2005.

T. Stylianopoulos, L. L. Munn, and R. K. Jain, Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy, Trends Cancer, vol.4, pp.258-259, 2018.

F. H. Chen, S. Y. Fu, Y. C. Yang, C. C. Wang, C. S. Chiang et al., Combination of vessel-targeting agents and fractionated radiation therapy: The role of the SDF-1/CXCR4 pathway, Int. J. Radiat. Oncol. Boil. Phys, vol.86, pp.777-784, 2013.

V. A. Potiron, R. Abderrahmani, K. Clement-colmou, S. Marionneau-lambot, T. Oullier et al., Improved functionality of the vasculature during conventionally fractionated radiation therapy of prostate cancer, PLoS ONE, issue.8, p.84076, 2013.

J. L. Kane, S. A. Krueger, A. Hanna, T. R. Raffel, G. D. Wilson et al., Effect of Irradiation on Tumor Microenvironment and Bone Marrow Cell Migration in a Preclinical Tumor Model, Int. J. Radiat. Oncol. Boil. Phys, vol.96, pp.170-178, 2016.

V. Potiron, K. Clement-colmou, E. Jouglar, M. Pietri, S. Chiavassa et al., Tumor vasculature remodeling by radiation therapy increases doxorubicin distribution and efficacy, Cancer Lett, vol.457, pp.1-9, 2019.
URL : https://hal.archives-ouvertes.fr/inserm-02265795

F. Hu, K. Vishwanath, J. K. Salama, A. Erkanli, B. Peterson et al., Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome, Int. J. Radiat. Oncol. Boil. Phys, vol.96, pp.462-469, 2016.

J. Lan, X. L. Wan, L. Deng, J. X. Xue, L. S. Wang et al., Ablative hypofractionated radiotherapy normalizes tumor vasculature in lewis lung carcinoma mice model, Radiat. Res, vol.179, pp.458-464, 2013.

M. Garcia-barros, F. Paris, C. Cordon-cardo, D. Lyden, S. Rafii et al., Tumor response to radiotherapy regulated by endothelial cell apoptosis, Science, vol.300, pp.1155-1159, 2003.

A. Jani, F. Shaikh, S. Barton, C. Willis, D. Banerjee et al., High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma, Int. J. Radiat. Oncol. Boil. Phys, vol.94, pp.1173-1180, 2016.

O. J. Kelada, R. H. Decker, S. K. Nath, K. L. Johung, M. Q. Zheng et al., High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors, Int. J. Radiat. Oncol. Boil. Phys, vol.102, pp.174-183, 2018.

F. Paris, Z. Fuks, A. Kang, P. Capodieci, G. Juan et al., Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice, Science, vol.293, pp.293-297, 2001.

H. J. Park, R. J. Griffin, S. Hui, S. H. Levitt, and C. W. Song, Radiation-induced vascular damage in tumors: Implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS), Radiat. Res, vol.177, pp.311-327, 2012.

F. Winkler, S. V. Kozin, R. T. Tong, S. S. Chae, M. F. Booth et al., Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases, Cancer Cell, vol.6, pp.553-563, 2004.

K. Burrell, R. P. Hill, and G. Zadeh, High-resolution in-vivo analysis of normal brain response to cranial irradiation, PLoS ONE, vol.7, p.38366, 2012.

C. W. Song, Y. J. Lee, R. J. Griffin, I. Park, N. A. Koonce et al., Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for

, Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery, Int. J. Radiat. Oncol. Boil. Phys, vol.93, pp.166-172, 2015.

A. Armulik, G. Genove, and C. Betsholtz, Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises, Dev. Cell, vol.21, pp.193-215, 2011.

V. G. Cooke, V. S. Lebleu, D. Keskin, Z. Khan, J. T. O'connell et al., Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway, Cancer Cell, vol.21, pp.66-81, 2012.

D. Keskin, J. Kim, V. G. Cooke, C. C. Wu, H. Sugimoto et al., Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2, Cell Rep, vol.10, pp.1066-1081, 2015.

J. S. Park, I. K. Kim, S. Han, I. Park, C. Kim et al., Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment, Cancer Cell, vol.30, pp.953-967, 2016.

J. Kim, P. C. De-sampaio, D. M. Lundy, Q. Peng, K. W. Evans et al., Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy, JCI Insight, vol.1, p.90733, 2016.

J. M. Ebos, C. R. Lee, W. Cruz-munoz, G. A. Bjarnason, J. G. Christensen et al., Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis, Cancer Cell, vol.15, pp.232-239, 2009.

M. Paez-ribes, E. Allen, J. Hudock, T. Takeda, H. Okuyama et al., Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis, Cancer Cell, vol.15, pp.220-231, 2009.

E. C. Watson, M. N. Koenig, Z. L. Grant, L. Whitehead, E. Trounson et al., Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis, vol.143, pp.2973-2982, 2016.

L. E. Benjamin, D. Golijanin, A. Itin, D. Pode, and E. Keshet, Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal, J. Clin. Investing, vol.103, pp.159-165, 1999.

J. D. Martin, D. Fukumura, D. G. Duda, Y. Boucher, and R. K. Jain, Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb, Perspect. Med, vol.6, pp.505-534, 2016.

C. Nieder and M. Baumann, Fractionation concepts, Re-Irradiation: New Fontiers, Medical Radiology, 2011.

J. M. Brown, D. J. Carlson, and D. J. Brenner, The tumor radiobiology of SRS and SBRT: Are more than the 5 Rs involved?, Int. J. Radiat. Oncol. Boil. Phys, vol.88, pp.254-262, 2014.

J. D. Martin, G. Seano, and R. K. Jain, Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges, Annu. Rev. Physiol, vol.81, pp.505-534, 2019.

M. M. Tomayko and C. P. Reynolds, Determination of subcutaneous tumor size in athymic (nude) mice, Cancer Chemother. Pharmacol, vol.24, pp.148-154, 1989.